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  • 1
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    Online Resource
    Tipifarnib Plus Tamoxifen in Tamoxifen-Resistant Metastatic Breast Cancer: A Negative Phase II and Screening of Potential Therapeutic Markers by Proteomic Analysis
    American Association for Cancer Research (AACR) ; 2010
    In:  Clinical Cancer Research Vol. 16, No. 4 ( 2010-02-15), p. 1264-1271
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 16, No. 4 ( 2010-02-15), p. 1264-1271
    Abstract: Purpose: Tipifarnib, a farnesyltransferase inhibitor, has antitumor activity in heavily pretreated metastatic breast cancer patients. Preclinical data suggest that FTIs could restore tamoxifen responsiveness in tamoxifen-resistant disease. Thus, combining FTIs and tamoxifen may be a promising clinical approach after relapse or progression on tamoxifen. Experimental Design: Postmenopausal patients with measurable estrogen receptor– and/or progesterone receptor–expressing metastatic breast cancers were enrolled. Only patients with disease progression on tamoxifen were eligible, but there was no limitation regarding prior chemotherapy or hormone therapy regimens. Patients were immediately treated with 300 mg (n = 12) or 200 mg (n = 10) tipifarnib twice daily for 21 of 28-day cycles plus tamoxifen once daily. Serum was collected at baseline and after 8 weeks of treatment to enable proteomic comparison and identify possible predictive response markers. Results: Twenty patients were enrolled and evaluated for efficacy: one patient had an objective response (liver metastasis) and nine had stable disease after 6 months for a clinical benefit rate of 50%; median duration of benefit was 10.3 (range, 7.4-20.2) months. The proteomic analysis by SELDI-TOF and LTQ-FT-Orbitrap identified a known peptide of fibrinogen α, the intensity of which was significantly increased in patients with progression compared with patients who benefited from the combined treatment after 8 weeks. Conclusions: Because the primary end point of efficacy (three objective responses) was not achieved, the study is negative. Nevertheless, the identified peptide could be of interest in discriminating, at 8 weeks of treatment, responders from nonresponders. Clin Cancer Res; 16(4); 1264–71
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1078-0432.CCR-09-1192
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
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    detail.hit.zdb_id: 2036787-9
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  • 2
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    How Predictability of Feeding Patches Affects Home Range and Foraging Habitat Selection in Avian Social Scavengers?
    Public Library of Science (PLoS) ; 2013
    In:  PLoS ONE Vol. 8, No. 1 ( 2013-1-3), p. e53077-
    Details
    In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 1 ( 2013-1-3), p. e53077-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0053077
    DOI: 10.1371/journal.pone.0053077.g001
    DOI: 10.1371/journal.pone.0053077.g002
    DOI: 10.1371/journal.pone.0053077.g003
    DOI: 10.1371/journal.pone.0053077.t001
    DOI: 10.1371/journal.pone.0053077.t002
    DOI: 10.1371/journal.pone.0053077.t003
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2013
    detail.hit.zdb_id: 2267670-3
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  • 3
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    Using recent baselines as benchmarks for megafauna restoration places an unfair burden on the Global South
    Wiley ; 2022
    In:  Ecography Vol. 2022, No. 4 ( 2022-04)
    Details
    In: Ecography, Wiley, Vol. 2022, No. 4 ( 2022-04)
    Abstract: The potential for megafauna restoration is unevenly distributed across the world, along with the socio‐political capacity of countries to support these restoration initiatives. We show that choosing a recent baseline to identify species' indigenous range puts a higher burden for megafauna restoration on countries in the Global South, which also have less capacity to support these restoration initiatives. We introduce the Megafauna Index, which considers large mammal's potential species richness and range area at the country level, to explore how the responsibility for megafauna restoration is distributed across the world according to four scenarios using various temporal benchmarks to define species' indigenous range – current, historical (1500 AD), mid‐Holocene and Pleistocene. We test how the distribution of restoration burden across the world correlates with indicators of conservation funding, human development and governance. Using a recent or historical baseline as a benchmark for restoration puts a higher pressure on African and south‐east Asian countries while lifting the responsibility from the Global North, where extinctions happened a long time ago. When using a mid‐Holocene or Pleistocene baseline, new opportunities arise for megafauna restoration in Europe and North America, respectively, where countries have a higher financial and societal capacity to support megafauna restoration. These results contribute to the debate around benchmarks in rewilding initiatives and the ethical implications of using recent baselines to guide restoration efforts. We suggest that countries from the Global North should reflect on their responsibility in supporting global restoration efforts, by both increasing their support for capacity building in the Global South and taking responsibility for restoring lost megafauna at home.
    Type of Medium: Online Resource
    ISSN: 0906-7590 , 1600-0587
    URL: Issue
    URL: Article
    DOI: 10.1111/ecog.v2022.i4
    DOI: 10.1111/ecog.05795
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    detail.hit.zdb_id: 1112659-0
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  • 4
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    A spatially explicit estimate of the prewhaling abundance of the endangered North Atlantic right whale
    Wiley ; 2016
    In:  Conservation Biology Vol. 30, No. 4 ( 2016-08), p. 783-791
    Details
    In: Conservation Biology, Wiley, Vol. 30, No. 4 ( 2016-08), p. 783-791
    Abstract: Una Estimación Espacialmente Explícita de la Abundancia Previa a la Caza de la Ballena Franca del Atlántico Norte en Peligro de Extinción Resumen La ballena franca del Atlántico Norte (BFAN) (Eubalaena glacialis) es una de las ballenas más amenazadas del mundo. Su extinción estuvo próxima después de casi un milenio de explotación y actualmente persiste una población de aproximadamente 500 individuos. El establecimiento de objetivos de conservación apropiados para esta especie requiere del entendimiento del tamaño histórico de la población como la línea base para la medida de los niveles de disminución y el progreso hacia la recuperación. Esto se dificulta por la escasez de registros sobre la larga historia de la caza de esta especie. Buscamos estimar el tamaño poblacional previo a la explotación de la ballena franca del Atlántico Norte y entender cómo se distribuía esta especie a lo largo de su extensión. Usamos un conjunto de datos espacialmente explícitos sobre las capturas históricas de las ballenas francas del Pacífico Norte (BFPN) (Eubalaena japonica) para modelar la relación entre la densidad relativa de ballenas francas y el ambiente durante la temporada de verano de alimentación. Cuando asumimos que las dos especies de ballenas francas seleccionan ambientes similares, pudimos proyectar este modelo hacia el Atlántico Norte y así poder predecir cómo la abundancia relativa de las BFAN varió a lo largo de su extensión. Calibramos estas abundancias relativas con los estimados del tamaño poblacional total previo a la caza de las BFPN y así obtener estimados altos y bajos para el tamaño poblacional general de las BFAN previo a la explotación. El modelo predijo la existencia de 9, 075 – 21, 328 ballenas francas en el Atlántico Norte. La población actual de BFAN es entonces 〈 6 % a la capacidad de carga histórica del Atlántico Norte, por lo que tiene un potencial enorme para la recuperación. De acuerdo al modelo, entre junio y septiembre, las BFAN se concentraron en dos áreas de alimentación principales: al este de los Grandes Bancos de Terranova y en el Mar de Noruega. Estas dos áreas pueden volverse importantes en el futuro como sitios de alimentación y puede que ya sean usadas por esta especie de manera más regular de lo que se cree.
    Type of Medium: Online Resource
    ISSN: 0888-8892 , 1523-1739
    URL: Issue
    URL: Article
    DOI: 10.1111/cobi.2016.30.issue-4
    DOI: 10.1111/cobi.12664
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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  • 5
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    Historical summer distribution of the endangered North Atlantic right whale ( Eubalaena glacialis ): a hypothesis based on environmental preferences of a congeneric species
    Wiley ; 2015
    In:  Diversity and Distributions Vol. 21, No. 8 ( 2015-08), p. 925-937
    Details
    In: Diversity and Distributions, Wiley, Vol. 21, No. 8 ( 2015-08), p. 925-937
    Abstract: To obtain a plausible hypothesis for the historical distribution of North Atlantic right whales ( NARW s) ( Eubalaena glacialis ) in their summer feeding grounds. Previously widespread in the North Atlantic, after centuries of hunting, these whales survive as a small population off eastern North America. Because their exploitation began before formal records started, information about their historical distribution is fragmentary. Location North Atlantic and North Pacific oceans. Methods We linked historical records of North Pacific right whales ( E. japonica ; from 19th‐century American whaling logbooks) with oceanographic data to generate a species distribution model. Assuming that the two species have similar environmental preferences, the model was projected into the North Atlantic to predict environmental suitability for NARWs. The reliability of these predictions was assessed by comparing the model results with historical and recent records in the North Atlantic. Results The model predicts suitable environmental conditions over a wide, mostly offshore band across the North Atlantic. Predictions are well supported by historical and recent records, but discrepancies in some areas indicate lower discriminative ability in coastal, shallow‐depth areas, suggesting that this model mainly describes the summer offshore distribution of right whales. Main conclusions Our results suggest that the summer range of the NARW consisted of a relatively narrow band (width c . 10° in latitude), extending from the eastern coast of North America to northern Norway, over the Grand Banks of Newfoundland, south of Greenland and Iceland, north of the British Isles and in the Norwegian Sea. These results highlight possibilities for additional research both on the history of exploitation and on the current summer distribution of this species. In particular, better survey coverage of historical whaling grounds could help inform conservation efforts for this endangered species. More generally, this study illustrates the challenges and opportunities in using historical data to understand the original distribution of highly depleted species.
    Type of Medium: Online Resource
    ISSN: 1366-9516 , 1472-4642
    URL: Issue
    URL: Article
    DOI: 10.1111/ddi.2015.21.issue-8
    DOI: 10.1111/ddi.12314
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2020139-4
    detail.hit.zdb_id: 1443181-6
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  • 6
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    Unshifting the baseline: a framework for documenting historical population changes and assessing long-term anthropogenic impacts
    The Royal Society ; 2019
    In:  Philosophical Transactions of the Royal Society B: Biological Sciences Vol. 374, No. 1788 ( 2019-12-23), p. 20190220-
    Details
    In: Philosophical Transactions of the Royal Society B: Biological Sciences, The Royal Society, Vol. 374, No. 1788 ( 2019-12-23), p. 20190220-
    Abstract: Ecological baselines—reference states of species' distributions and abundances—are key to the scientific arguments underpinning many conservation and management interventions, as well as to the public support to such interventions. Yet societal as well as scientific perceptions of these baselines are often based on ecosystems that have been deeply transformed by human actions. Despite increased awareness about the pervasiveness and implications of this shifting baseline syndrome, ongoing global assessments of the state of biodiversity do not take into account the long-term, cumulative, anthropogenic impacts on biodiversity. Here, we propose a new framework for documenting such impacts, by classifying populations according to the extent to which they deviate from a baseline in the absence of human actions. We apply this framework to the bowhead whale ( Balaena mysticetus ) to illustrate how it can be used to assess populations with different geographies and timelines of known or suspected impacts. Through other examples, we discuss how the framework can be applied to populations for which there is a wide diversity of existing knowledge, by making the best use of the available ecological, historical and archaeological data. Combined across multiple populations, this framework provides a standard for assessing cumulative anthropogenic impacts on biodiversity. This article is part of a discussion meeting issue ‘The past is a foreign country: how much can the fossil record actually inform conservation?’
    Type of Medium: Online Resource
    ISSN: 0962-8436 , 1471-2970
    URL: Article
    DOI: 10.1098/rstb.2019.0220
    RVK:
    WA 15000
    Language: English
    Publisher: The Royal Society
    Publication Date: 2019
    detail.hit.zdb_id: 1462620-2
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  • 7
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    Information on population trends and biological constraints from bat counts in roost cavities: a 22-year case study of a pipistrelle bats (Pipistrellus pipistrellus Schreber) hibernaculum
    CSIRO Publishing ; 2015
    In:  Wildlife Research Vol. 42, No. 1 ( 2015), p. 35-
    Details
    In: Wildlife Research, CSIRO Publishing, Vol. 42, No. 1 ( 2015), p. 35-
    Abstract: Context According to the current trend of biodiversity loss, information on population trends at large temporal and spatial scales is necessary. However, well documented animal population dynamics are generally based on intensive protocols requiring animal manipulation, which can be impossible to conduct in species for which conservation is a concern. Aims For many bat species, an alternative approach entails performing an appropriate analysis of counts in roost cavities. Because of managers’ perception of chaotic variations through time, relatively few count monitoring surveys are regularly analysed. Here, we present the analysis of a twenty-two-year survey of a large hibernaculum of pipistrelle bats (Pipistrellus pipistrellus) located in a railway tunnel in Paris, France. Methods We propose that using combinations of population-dynamics modelling using demographic parameters from the literature and statistical analyses helps with identifying the biological and methodological effects underlying the dynamics observed in census analyses. Key results We determined that some of the observed year-to-year variations of population size cannot be explained only by the intrinsic dynamics of the population. In particular, in 1993–94, the population size increased by 〉 40%, which should have implied a massive immigration. This change coincided with the end of the operation of the railway line. After consideration of a drastic trend of population decline (7% year–1), we were able to detect this event and several environmental effects. Specifically, the winter conditions and the temperature in July affected the colony size, presumably because of aggregative behaviour and reproduction success, respectively. Conclusions Emigration–immigration processes might have preponderant effects on population dynamics. In addition, our analysis demonstrated that (1) the study population suffered a large decline, (2) a combination of human disturbance and meteorological variation explains these dynamics and (3) emigration–immigration processes have preponderant effects on the population dynamics. Implications To conduct a meaningful analysis of non-standard time series and provide a source of data for implementing biodiversity indicators, it is necessary to include (1) the local knowledge of the people involved in the field surveys in these analyses (the existence of disturbances and site protections) and (2) meteorological information for the appropriate seasons of the year.
    Type of Medium: Online Resource
    ISSN: 1035-3712
    URL: Article
    DOI: 10.1071/WR14197
    Language: English
    Publisher: CSIRO Publishing
    Publication Date: 2015
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  • 8
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    Presentation1.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-7-13)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-7-13)
    Abstract: Traditional thin sectioning microscopy of large bone and dental tissue samples using demineralization may disrupt structure morphologies and even damage soft tissues, thus compromising the histopathological investigation. Here, we developed a synergistic and original framework on thick sections based on wide-field multi-fluorescence imaging and spectral Principal Component Analysis (sPCA) as an alternative, fast, versatile, and reliable solution, suitable for highly mineralized tissue structure sustain and visualization. Periodontal 2-mm thick sections were stained with a solution containing five fluorescent dyes chosen for their ability to discriminate close tissues, and acquisitions were performed with a multi-zoom macroscope for blue, green, red, and NIR (near-infrared) emissions. Eigen-images derived from both standard scaler (Std) and Contrast Limited Adaptive Histogram Equalization (Clahe) pre-preprocessing significantly enhanced tissue contrasts, highly suitable for histopathological investigation with an in-depth detail for sub-tissue structure discrimination. Using this method, it is possible to preserve and delineate accurately the different anatomical/morphological features of the periodontium, a complex tooth-supporting multi-tissue. Indeed, we achieve characterization of gingiva, alveolar bone, cementum, and periodontal ligament tissues. The ease and adaptability of this approach make it an effective method for providing high-contrast features that are not usually available in standard staining histology. Beyond periodontal investigations, this first proof of concept of an sPCA solution for optical microscopy of complex structures, especially including mineralized tissues opens new perspectives to deal with other chronic diseases involving complex tissue and organ defects. Overall, such an imaging framework appears to be a novel and convenient strategy for optical microscopy investigation.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    URL: Article
    DOI: 10.3389/fphys.2022.899626
    DOI: 10.3389/fphys.2022.899626.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 9
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    Shifted distribution baselines: neglecting long-term biodiversity records risks overlooking potentially suitable habitat for conservation management
    The Royal Society ; 2019
    In:  Philosophical Transactions of the Royal Society B: Biological Sciences Vol. 374, No. 1788 ( 2019-12-23), p. 20190215-
    Details
    In: Philosophical Transactions of the Royal Society B: Biological Sciences, The Royal Society, Vol. 374, No. 1788 ( 2019-12-23), p. 20190215-
    Abstract: Setting appropriate conservation measures to halt the loss of biodiversity requires a good understanding of species' habitat requirements and potential distribution. Recent (past few decades) ecological data are typically used to estimate and understand species’ ecological niches. However, historical local extinctions may have truncated species–environment relationships, resulting in a biased perception of species' habitat preferences. This may result in incorrect assessments of the area potentially available for their conservation. Incorporating long-term (centuries-old) occurrence records with recent records may provide better information on species–environment relationships and improve the modelling and understanding of habitat suitability. We test whether neglecting long-term occurrence records leads to an underestimation of species’ historical niche and potential distribution and identify which species are more vulnerable to this effect. We compare outputs of species distribution models and niche hypervolumes built using recent records only with those built using both recent and long-term (post-1500) records, for a set of 34 large mammal species in South Africa. We find that, while using recent records only is adequate for some species, adding historical records in the analyses impacts estimates of the niche and habitat suitability for 12 species (34%) in our dataset, and that this effect is significantly higher for carnivores. These results show that neglecting long-term biodiversity records in spatial analyses risks misunderstanding, and generally underestimating, species' niches, which in turn may lead to ill-informed management decisions, with significant implications for the effectiveness of conservation efforts. This article is part of a discussion meeting issue ‘The past is a foreign country: how much can the fossil record actually inform conservation?’
    Type of Medium: Online Resource
    ISSN: 0962-8436 , 1471-2970
    URL: Article
    DOI: 10.1098/rstb.2019.0215
    RVK:
    WA 15000
    Language: English
    Publisher: The Royal Society
    Publication Date: 2019
    detail.hit.zdb_id: 1462620-2
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  • 10
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    Supporting the restoration of complex ecosystems requires long‐term and multi‐scale perspectives
    Wiley ; 2022
    In:  Ecography Vol. 2022, No. 4 ( 2022-04)
    Details
    In: Ecography, Wiley, Vol. 2022, No. 4 ( 2022-04)
    Type of Medium: Online Resource
    ISSN: 0906-7590 , 1600-0587
    URL: Issue
    URL: Article
    DOI: 10.1111/ecog.v2022.i4
    DOI: 10.1111/ecog.06354
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2024917-2
    detail.hit.zdb_id: 1112659-0
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