In:
Phytotherapy Research, Wiley, Vol. 25, No. 4 ( 2011-04), p. 493-500
Abstract:
A long‐term experimental animal model was developed by our research group for the evaluation of potential chemopreventive effects. The inhibitory effects of agents on carcinogen (7,12‐dimethylbenz[a]anthracene (DMBA) induced molecular epidemiological biomarkers, in this case the expression of key onco/suppressor genes were investigated. The expression pattern of c‐myc , Ha‐ras , Bcl‐2 , K‐ras protooncogene and p53 tumour suppressor gene were studied to elucidate early carcinogenic and potential chemopreventive effects. The consumption of so‐called Claw of Dragon tea (CoD™ tea) containing the bark of Uncaria guianensis , Cat's Claw (Uncaria sp. U. tomentosa ) and Palmer trumpet‐tree (Tabebuia sp. T. avellanedae ) was able to decrease the DMBA‐induced onco/suppressor gene overexpression in a short‐term animal experiment. In a following study CBA/Ca mice were treated with 20 mg/kg bw DMBA intraperitoneally (i.p.) and the expression patterns of onco/suppressor genes were examined at several time intervals. According to the examined gene expression patterns in this long‐term experiment the chemopreventive effect of CoD™ tea consumption could be confirmed. Copyright © 2010 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0951-418X
,
1099-1573
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1493490-5
SSG:
15,3
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