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  • 1
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    Fig. 3. Types of Mullerian duct anomalies in the study group
    ECO-Vector LLC ; 2021
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 11, No. 3 ( 2021-10-13), p. 315-324
    Details
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 11, No. 3 ( 2021-10-13), p. 315-324
    Abstract: BACKGROUND: The preserved cloaca is a particular type of anorectal anomaly. The combination of urological, genital, and rectal abnormalities makes radical reconstruction difficult. MATERIALS AND METHODS: This study examined operations performed in 50 patients with persistent cloaca treated from 2010 to 2021. Two groups are presented: the first with 35 children and a short canal (3 cm), and the second with 15 children and a long canal (3 cm). We examined the prognosis for bowel control, the type of operation, the need for vaginal reconstruction, complications after surgery, and the days of hospital stay. RESULTS: Anomalies of the Mllerian ducts in the second group (94%) were higher than in the first (36%) (p 0.001). The sacral index and myelodysplasia did not differ in both groups. The sacral index in the first group was 0.62 0.14, and in the second group, it was 0.58 0.14 (p = 0.520). Myelodysplasia in the first group was 33%, and in the second group, it was 38% (p = 0.744). Total urogenital mobilization (51%) was used in the first group, and abdominal reconstruction (54%) was used in the second group. Vaginal reconstruction was required in 28% of patients in the first group and 60% in the second group. Complications were 3.5 times more likely in the first group (60% versus 17% in the second) (p = 0.003). The length of hospital stay in patients in the second group was longer than that of patients in the first group. CONCLUSION: Our study data demonstrate that the reconstruction of a persistent cloaca requires individual planning of the operation, considering the length of the canal and the state of all structures forming the cloaca.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.17816/psaic.20213
    DOI: 10.17816/psaic985
    DOI: 10.17816/psaic985-592
    DOI: 10.17816/psaic985-593
    DOI: 10.17816/psaic985-594
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2021
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  • 2
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    Intestinal anastomoses in children: The draft decision of the Russian Symposium of Children surgeons (April 2023)
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 13, No. 2 ( 2023-07-15), p. 271-279
    Details
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 13, No. 2 ( 2023-07-15), p. 271-279
    Abstract: The Symposium of Pediatric Surgeons of Russia, Intestinal Anastomoses in Children, was conducted in Volgograd on April 26, 2023, with around 180 doctors in attendance. Thirty papers were presented and discussed, and 41 articles were published in the proceedings of the symposium. According to the results of a systemic analysis of a questionnaire poll of major pediatric surgeons in 75 regions of Russia, 4,558 surgeries on intestinal anastomosis formation were performed in 20212022, including 1,735 operations in newborn children (36%); their share in general pediatric surgery was less than 0.6%, and it was more than 18.6% in neonatal surgeons. The number of intestinal anastomoses formed during laparoscopic procedures increased (4.4%). Pediatric surgeons equally often used double-row nodal intestinal sutures (33.3%), single-row continuous sutures (34.6%), and different types of sutures (33.3%). A T-shaped anastomosis was performed in cases of necrotizing enterocolitis where there was a significant difference in the diameters of the intestine's inflow and outflow channels. The clip-and-drop technique was used to treat neonates with multifocal necroses. Interintestinal anastomoses were favored over enterostomies in numerous segmental resections. For duodenal obstruction, duodeno-duodenal, and duodeno-jejunal anastomoses were performed. In children with Crohn's disease and choledochal cysts, most specialists prefer operations with stapling devices. Creating a magnetic interintestinal anastomosis lowers the risk of postoperative complications and facilitates the postoperative period. Clinical observations after laparoscopic surgeries accounted for a significant proportion of complications (66%). Anastomosis failure was three times more common in planned small intestinal in older children than in emergency surgeries (1.2 and 0.4%, respectively). The modern stage of development of intestinal anastomosis formation techniques in children is characterized by good results, the expansion of indications for intestinal anastomosis in conditions of compromised colon or peritonitis, and the introduction of laparoscopic techniques and mechanical stapling devices with slightly poorer results.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    URL: Article
    DOI: 10.17816/psaic.20232
    DOI: 10.17816/psaic1526
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 3
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    Fig. 2. Malrotation in patients with duodenal obstruction
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 12, No. 1 ( 2022-04-12), p. 9-18
    Details
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 12, No. 1 ( 2022-04-12), p. 9-18
    Abstract: BACKGROUND: Duodenal atresia is one of the most common malformations of the intestine in newborns. Both open surgical interventions and the laparoscopic method eliminate duodenal obstruction. AIM: This study conducts a comparative analysis of the results of treating newborns by these methods. MATERIALS AND METHODS: This paper summarizes the experience of treating 185 newborns operated in the clinic for duodenal obstruction. Two groups of patients are presented: the first included 110 children operated on laparoscopically, the second included 75 patients operated on by the open method. Both groups are comparable regarding newborn anthropometric data, age at the time of surgery, and the presence of concomitant anomalies. The study considered indicators characterizing the surgical intervention and the course of the postoperative period. RESULTS: In a series of studies, there were no differences between groups in interpreting the cause of obstruction (p = 0.184) and the presence of an incomplete turn (p = 0.134). Operating time in the laparoscopy group was higher than in the laparotomy group (75 min and 70 min, p 0.001). However, the reduced duration of mechanical ventilation, earlier initiation of feeding, transition to complete enteral nutrition and reduced length of hospital stay suggest the benefits of laparoscopy over laparotomy for treating congenital duodenal obstruction (p 0.001). The frequency of postoperative complications is not high in both groups (p = 0.634). The analysis results showed that laparoscopy does not complicate the intraoperative interpretation of organ relationships, provides a more favorable course during the postoperative period, and does not increase the number of postoperative complications. CONCLUSION: The laparoscopic method improves medical efficiency in treating newborns with duodenal obstruction than open surgery.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.17816/psaic.20221
    DOI: 10.17816/psaic1002
    DOI: 10.17816/psaic1002-765
    DOI: 10.17816/psaic1002-766
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 4
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    Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers
    Proceedings of the National Academy of Sciences ; 2020
    In:  Proceedings of the National Academy of Sciences Vol. 117, No. 37 ( 2020-09-15), p. 22841-22848
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 117, No. 37 ( 2020-09-15), p. 22841-22848
    Abstract: Quantum mechanics/molecular mechanics (QM/MM) maturation of an immunoglobulin (Ig) powered by supercomputation delivers novel functionality to this catalytic template and facilitates artificial evolution of biocatalysts. We here employ density functional theory-based (DFT-b) tight binding and funnel metadynamics to advance our earlier QM/MM maturation of A17 Ig-paraoxonase (WTIgP) as a reactibody for organophosphorus toxins. It enables regulation of biocatalytic activity for tyrosine nucleophilic attack on phosphorus. The single amino acid substitution l -Leu47Lys results in 340-fold enhanced reactivity for paraoxon. The computed ground-state complex shows substrate-induced ionization of the nucleophilic l -Tyr37, now H-bonded to l -Lys47, resulting from repositioning of l -Lys47. Multiple antibody structural homologs, selected by phenylphosphonate covalent capture, show contrasting enantioselectivities for a P-chiral phenylphosphonate toxin. That is defined by crystallographic analysis of phenylphosphonylated reaction products for antibodies A5 and WTIgP. DFT-b analysis using QM regions based on these structures identifies transition states for the favored and disfavored reactions with surprising results. This stereoselection analysis is extended by funnel metadynamics to a range of WTIgP variants whose predicted stereoselectivity is endorsed by experimental analysis. The algorithms used here offer prospects for tailored design of highly evolved, genetically encoded organophosphorus scavengers and for broader functionalities of members of the Ig superfamily, including cell surface-exposed receptors.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2010317117
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2020
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 5
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    The Effectiveness of Using a Complex Synbiotic Feed Additive for Lactating Cows during the Milking Period
    Vologda Research Center of the RAS ; 2024
    In:  Agricultural and Lifestock Technology / АгроЗооТехника , No. 1 (25) ( 2024)
    Details
    In: Agricultural and Lifestock Technology / АгроЗооТехника, Vologda Research Center of the RAS, , No. 1 (25) ( 2024)
    Type of Medium: Online Resource
    ISSN: 2658-7912
    Uniform Title: Эффективность использования комплексной синбиотической кормовой добавки в период раздоя лактирующих коров
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.15838/alt.2024.7.1
    DOI: 10.15838/alt
    DOI: 10.15838/alt.2024.7.1.2
    Language: Unknown
    Publisher: Vologda Research Center of the RAS
    Publication Date: 2024
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  • 6
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    The results of treatment of newborns with right-sided and left-sided intrathoracic localization of the liver with diaphragmatic hernia
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 12, No. 4 ( 2023-01-19), p. 401-410
    Details
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 12, No. 4 ( 2023-01-19), p. 401-410
    Abstract: BACKGROUND: The right-sided congenital diaphragmatic hernia is the rare pathology. Results of diagnostics, prognosis and treatment usally published as a collection of cases. AIM: Comparition of treatment results of congenital diaphragmatic hernia with the liver as its content in dependancy of the side. MATERIALS AND METHODS: We present a retrospective analysis of 50 newborn patients with congenital diaphragmatic hernia. Patiens were divided in two groups, first with right-sided (19 patients), and second with left-sided hernia (31 patients). Groups were compared by gender and weigth. Comparition criteria was the results of prenatal and postnatal diagnostics, intraoperative data, postoperative period, complications and outcomes. RESULTS: We found predominance of prenatal diagnosis in the second group (48% vs 84%, p = 0,001). The lung-to-head circumference ratio were the same in both groups (0,52 in first, 0,46 in second, p = 0,058). Chance to use thoracoscopic approach in the second group was higer in 5,7 times (48% vs 84%). Postoperative period was easier in the group of right-sided congenital diaphragmatic hernia: artificial ventilation lasted on average 8 days (min 3; max 28) versus 11 (min 4; max 50) days in the first group (p = 0,036). Hospital stay was significantly lower in the second group 18 days (min 12; max 28), versus 50 days in the first group (min 13; max 64), p = 0,011. Recovery chance in patients with right-sided hernia was higher (45% vs 79%, confidence interval 0,0590,814). CONCLUSIONS: Every type of diaphragmatic hernia, including right-sided location, need to be the subgect of research of high compitantive center. Prognostic criteria for right-sided congenital diaphragmatic hernia require furter advanced study, wich is possible only in case of concentration of patients in the same center.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    URL: Article
    DOI: 10.17816/psaic.20224
    DOI: 10.17816/psaic1291
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 7
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    Long-term treatment results of hydronephrosis in children operated in their first year of life. A systematic review
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 13, No. 2 ( 2023-07-15), p. 189-200
    Details
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 13, No. 2 ( 2023-07-15), p. 189-200
    Abstract: BACKGROUND: Congenital stenosis of the ureterоpelvic junction is the most common cause of hydronephrosis in children. AIM: This systematic review aimed to search and analyze modern literature from 1998 to 2021 on the treatment and postoperative follow-up of children with severe hydronephrosis in the first year of life and study the long-term results. MATERIALS AND METHODS: Literary sources were searched in PubMed, Web of Science, Scopus, Google Scholar, and eLibrary databases. The following keywords were used to search for English sources: congenital hydronephrosis, severe hydronephrosis, operative treatment, uretero-pelvic junction obstruction infant, children, neonatal, and infancy. Five full-text articles that meet the criteria were included for analysis. RESULTS: A total of 355 patients were included in the publications. Antenatal screening was described only in two studies. The average age of children at the time of surgery was five months (one to six months). All the authors noted that due to pyeloplasty in the first year of life, the renal parenchyma exhibited a significant increase in thickness; the indicators in dynamics increased by an average of 1.5 times during the year. The size of the renal pelvis decreased by 50%67%. The data of radioisotope scintigraphy were variable; however, in the long-term period, improvement in renal function was noted in all publications. CONCLUSIONS: This systematic review shows the long-term results of early pyeloplasty in congenital hydronephrosis in young children. A significant decrease in the pelvis and an increase in the thickness of the parenchyma were observed, both of which are an advantage for the restoration of renal function. However, no single algorithm can predict the recovery of renal parenchyma. An accurate assessment of renal parenchymal function should be confirmed by a prospective, randomized, long-term, follow-up study with a large number of cases.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    URL: Article
    DOI: 10.17816/psaic.20232
    DOI: 10.17816/psaic1301
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 8
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    Physiotherapy in the Сomplex Rehabilitation of Children with Anorectal Malformations: Systematic Review
    National Medical Research Center For Rehabilitation And Balneology ; 2021
    In:  Bulletin of Rehabilitation Medicine Vol. 20, No. 4 ( 2021-8-31), p. 28-34
    Details
    In: Bulletin of Rehabilitation Medicine, National Medical Research Center For Rehabilitation And Balneology, Vol. 20, No. 4 ( 2021-8-31), p. 28-34
    Abstract: Medical rehabilitation is an integral part of the treatment for surgical patients. Regarding pediatric patients with anorectal malformations, the success of the result of surgical treatment is mainly a correctly selected rehabilitation program, including methods of individual physiotherapy. Disturbances of intestinal transit, such as chronic constipation and anal incontinence, according to the world literature, occur in the study group in up to 30% of cases. According to the social significance of constipation and anal incontinence, the psychological aspects, the disabling component, children with anorectal malformations need early and long-term rehabilitation, adapted to their needs. At the moment, there are regulatory documents describing the principles of medical rehabilitation of children, its main characteristics, however, there are no protocols for the use of physiotherapy methods regarding the manifestations of colon transit disorders. Aim. Analysis of modern literature data on physiotherapeutic methods of rehabilitation of children with anorectal malformations. Material and methods. After determining the research criteria, a basic literature review using Web of Science, PubMed, electronic library was conducted, as a result 186 articles were selected that met the search criteria. After the initial assessment, 10 full-text articles were accepted for the analysis. Results. We have assessed the opportunity and mechanisms of the therapeutic action of sacral stimulation and tibial neuromodulation, the effect of various types of currents and a high-intensity magnetic field on the muscles of the complex, studied the possibility and results of using biofeedback therapy in children with colon transit disorders after operations on the anorectal body area in 421 children in 10 studies. Conclusion. Based on the results of scientific research, a range of physiotherapy methods have been established that are effective in relation to rehabilitation measures in children with anorectal malformations.
    Type of Medium: Online Resource
    ISSN: 2078-1962
    URL: Journal
    URL: Article
    DOI: 10.38025/2078-1962
    DOI: 10.38025/2078-1962-2021-20-4-28-34
    Language: Russian
    Publisher: National Medical Research Center For Rehabilitation And Balneology
    Publication Date: 2021
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  • 9
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    Infravesical Obstruction in a Boy with Orthotopic Ureterocele: Clinical Case
    Paediatrician Publishers LLC ; 2023
    In:  Current Pediatrics Vol. 22, No. 2 ( 2023-05-07), p. 202-206
    Details
    In: Current Pediatrics, Paediatrician Publishers LLC, Vol. 22, No. 2 ( 2023-05-07), p. 202-206
    Abstract: Background . Ureterocele is a cystic dilatation of the distal ureter. Orthotopic ureterocele is relatively rare form of this disease, and it is commonly diagnosed in female children. The clinical picture of orthotopic ureterocele is usually not significant, and the management variants are unclear. Clinical case description. Ultrasound has revealed dilatation in the distal part of the left ureter (up to 6.5 mm) and cyst formation (diameter of 8 mm, thick walls) in the bladder in 8-months-old boy. The retrograde voiding cystourethrogram has shown no signs of vesicoureteral reflux. The evaluation of the voiding rhythm was performed: the volume of residual urine was 〉 30%, it indicates the infravesical obstruction. The child underwent diagnostic cystourethroscopy, transurethral resection of the ureterocele, intubation ureteral catheter in the left ureter (all procedures was performed under general anesthesia). There were no enlargements of calices-pelvis system and ureters 12 months after surgery according to urinary system ultrasound. Clinical urine test with no inflammatory changes. Voiding rhythm was without pathology. Conclusion . The widespread implementation of high-tech and minimally invasive methods of diagnosis and management allow us to achieve timely detection and provide effective treatment for children with ureterocele.
    Type of Medium: Online Resource
    ISSN: 1682-5535 , 1682-5527
    URL: Article
    DOI: 10.15690/vsp.v22i2.2564
    Language: Unknown
    Publisher: Paediatrician Publishers LLC
    Publication Date: 2023
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  • 10
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    Model of urologic treatMent in newborns and infants
    Contemporary Clinical Medicine ; 2013
    In:  The Bulletin of Contemporary Clinical Medicine Vol. 6, No. 6 ( 2013), p. 40-44
    Details
    In: The Bulletin of Contemporary Clinical Medicine, Contemporary Clinical Medicine, Vol. 6, No. 6 ( 2013), p. 40-44
    Type of Medium: Online Resource
    ISSN: 2071-0240 , 2079-553X
    Uniform Title: Модель оказания урологической поМощи новорожденныМ и детяМ раннего возраста
    URL: Article
    DOI: 10.20969/VSKM.2013.6(6).40-44
    Language: Unknown
    Publisher: Contemporary Clinical Medicine
    Publication Date: 2013
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