In:
International Journal of Cancer, Wiley, Vol. 142, No. 6 ( 2018-03-15), p. 1230-1243
Abstract:
What's new? The molecular genetic basis of uterine leiomyosarcoma (uLMS), a rare but extremely lethal cancer type, remains poorly characterized. Through an integrated analysis of genomic and transcriptomic data generated in a large cohort of 84 uLMS patients, here the authors identified several cancer driver genes contributing to uLMS. Most of these genes are known cancer drivers ( TP53 , RB1 , etc.), whereas several others ( CCNE1 , FGFR , etc.) represent potential therapeutic targets for which drugs are already available or being developed. The data also identified VIPR2 , a negative regulator of smooth muscle cell proliferation, as a potential novel tumor suppressor gene in uLMS.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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