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  • 1
    Online Resource
    Online Resource
    Pharmacological Importance of Sage and Oregano
    Open Access Pub ; 2020
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 2 ( 2020-4-30), p. 13-17
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 2 ( 2020-4-30), p. 13-17
    Abstract: Sage and Oregano, both are well-known culinary herbs with potential medicinal uses. Sage is mostly used to cease wounds bleeding, treating sores, swelling, cough and ulcers back in the first century and was called as the fertility drug since it reduces excessive bleeding during menstruation. On the other hand Oregano was found to be effective in treating stomach discomforts, bacterial/fungal infection, inflammatory bowel disease etc. Therefore due to their therapeutic and native applications, Sage and Oregano is of high economic worth.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-20-3331
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    Analysis of Isotopic Abundance Ratio of Consciousness Energy Healing Treated Metronidazole Using LC-MS and GC-MS Spectrometry
    Open Access Pub ; 2020
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 3 ( 2020-11-24), p. 26-36
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 3 ( 2020-11-24), p. 26-36
    Abstract: Metronidazole is an antibiotic and useful for the antibacterial and antiprotozoal medication. This study was performed to investigate the impact of the Trivedi Effect®-Biofield Energy Healing Treatment on the structural properties and the isotopic abundance ratio of metronidazole using LC-MS and GC-MS spectroscopy. Metronidazole sample was divided into two parts, one part of metronidazole was considered as control (no Biofield Energy Treatment was provided), while the second part was treated with the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton and termed as a treated sample. The LC-MS spectra of both the samples of metronidazole at the retention time (Rt) 2.61 minutes exhibited the mass of the protonated molecular ion peak at m/z 172 M+H+ (calculated for C6H10N3O3+, 172.07). The LC-MS based isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 15N/214N or 17O/16O) in the treated metronidazole was significantly increased by 8.24% compared with the control sample. Thus,13C, 2H, 15N,and17O contributions from (C6H10N3O3)+ to m/z 173 in the treated sample were significantly increased compared with the control sample. The GC-MS based isotopic abundance ratio of PM+1/PM in the treated metronidazole was significantly increased by 5.92% compared with the control sample. Hence,13C, 2H, 15N, and217O contributions from (C6H9N3O3)+ to m/z 172 in the Biofield Energy Treated sample were significantly increased compared with the control sample. However, the isotopic abundance ratio of PM+2/PM in the treated metronidazole was significantly decreased by 18.2% compared with the control sample. Hence,18O contributions from (C6H9N3O3)+ to m/z 173 in the treated sample were significantly decreased compared with the control sample. The isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 15N/14N or 17O/16O) and PM+2/PM (18O/16O) in the treated metronidazole was significantly altered compared to the control sample. From the results, it can be hypothesized that the changes in isotopic abundance and mass peak intensities could be due to changes in nuclei possibly through the interference of neutrino particles via the Trivedi Effect® - Consciousness Energy Healing Treatment. The new form of treated metronidazole would be better designing novel pharmaceutical formulations that might offer better therapeutic response against bacterial and protozoal infection in the vagina (bacterial vaginosis), stomach (giardiasis, trichomoniasis, pseudomembranous colitis), joints (pelvic inflammatory disease), liver, skin, brain, and respiratory tract, aspiration pneumonia, rosacea, intra-abdominal infections, lung abscess, fungating wounds, periodontitis, amoebiasis, oral infections, etc.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-20-3618
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2020
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  • 3
    Online Resource
    Online Resource
    Review article on Analytical Techniques of Lamivudine Determination in Different Matrices
    Open Access Pub ; 2021
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 3 ( 2021-1-5), p. 37-46
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 3 ( 2021-1-5), p. 37-46
    Abstract: In this literature review, we will introduce most of up-to-date reported methods that have been developed for determination of lamivudine in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-20-3664
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    Yasmin Induced Pulmonary Embolism: a Case Report
    Open Access Pub ; 2021
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 3, No. 1 ( 2021-5-10), p. 1-3
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 3, No. 1 ( 2021-5-10), p. 1-3
    Abstract: We evaluate a case report of Yasmin induced pulmonary embolism in order to provide reference for safety use of oral contraceptives.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-21-3586
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis
    Springer Science and Business Media LLC ; 2023
    In:  AAPS PharmSciTech Vol. 24, No. 7 ( 2023-09-19)
    Details
    In: AAPS PharmSciTech, Springer Science and Business Media LLC, Vol. 24, No. 7 ( 2023-09-19)
    Abstract: A severe form of autoimmune-mediated inflammatory bowel disease (IBD) is termed as ulcerative colitis (UC) which ultimately results in significant mucosal damage and ulceration. Herbal remedies may be employed as an alternative for treatment of UC instead of conventional medications such as Sulfasalazine. Promising natural remedies for the treatment of IBD, including colitis, are propolis extract (PP) and thymoquinone (TQ). This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects. Clinical, biochemical, and histological evaluations of colonic mucosal damage and inflammation were evaluated. The results exhibited a significant increase in tissue MDA, TNFα, and nitrite levels with activation of caspase-3 in the acetic acid-induced colitis group, which is predominantly downregulated in the treatment groups. The prepared formulations of TQ and PP revealed liposomal vesicles in a nanoscale size (192 ± 20.3 and 98.2 ± 20.3 nm, respectively) and accepted stability indicated with a zeta potential of 19.3 ± 0.11 and 17.1 ± 0.25 mV, respectively. They showed an entrapment efficiency of 85.3 ± 12.6% and 69.3 ± 11.8%, respectively. At comparable doses, combination therapy with thymoquinone liposomes and propolis liposomes considerably outperformed free TQ and free PP in reducing inflammation of UC as shown in the present study by clinical, biochemical, and histological evaluations.
    Type of Medium: Online Resource
    ISSN: 1530-9932
    URL: Article
    DOI: 10.1208/s12249-023-02637-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2052070-0
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  • 6
    Online Resource
    Online Resource
    The Potential of Optimized Liposomes in Enhancement of Cytotoxicity and Apoptosis of Encapsulated Egyptian Propolis on Hep-2 Cell Line
    MDPI AG ; 2021
    In:  Pharmaceutics Vol. 13, No. 12 ( 2021-12-17), p. 2184-
    Details
    In: Pharmaceutics, MDPI AG, Vol. 13, No. 12 ( 2021-12-17), p. 2184-
    Abstract: Purpose: Development of pharmaceutical dosage forms of natural products has gained great interest recently. Propolis is a natural product with various active compounds and multiple pharmacological activities. Its resinous nature and low bioavailability were obstacles in the optimum use of this magnificent natural product. Aim: This study evaluates the effect of using liposomes as a drug delivery system on the enhancement of the cytotoxic effect of propolis on squamous cell carcinoma cell lines (Hep-2) of head and neck. Methods: An optimized liposomal formulation of propolis was prepared using the conventional thin film hydration method 1, 2. The prepared (Hep-2) cell line was treated with different concentrations of propolis and optimized propolis liposomes for 24 h. The effect of both propolis and propolis liposomes on cell line was investigated using MTT assay, cytological examination, and nuclear morphometric analysis. The effect of the drugs on the cell apoptosis was evaluated using Annexin V. Results: The findings revealed that both propolis and propolis liposomes have a cytotoxic effect on Hep-2 cell line through induction of apoptosis. The effect was dose dependent. However, a statistically significant enhancement in propolis-mediated apoptosis on Hep-2 cells was elucidated due to encapsulation within the prepared liposomes. Conclusion: Liposome is a powerful tool for enhancing the cytotoxicity of propolis against Hep-2 cell line.
    Type of Medium: Online Resource
    ISSN: 1999-4923
    URL: Article
    DOI: 10.3390/pharmaceutics13122184
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2527217-2
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Evaluation of Job Satisfaction and Job Related Stress Among Community Pharmacists in North Khartoum and its Impact on Providing Pharmaceutical Care Services
    Open Access Pub ; 2019
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 2 ( 2019-11-11), p. 1-12
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 2 ( 2019-11-11), p. 1-12
    Abstract: Introduction Pharmacists and pharmaceutical care services are among the most important tools in providing health services to the society. Pharmacists as the key players in presenting health services, critically impact on the health of the society and if they suffer low job satisfaction, their dissatisfaction may relatively threaten health in the society. This study was conducted to determine Sudanese community pharmacists’ job satisfaction and additionally, some causes of dissatisfaction among community pharmacists and their impact on providing pharmaceutical care services have been evaluated. Method The questionnaire was designed after reviewing relevant Literature in addition, The Job Satisfaction survey was used to measure the level of community pharmacists’ satisfaction with their current jobs, and the Toronto Alexithymia Scale (TAS-20) was used to evaluate emotional experience and awareness. Results and Discussion Generally low scores of job satisfaction were concluded among pharmacists while most of them were highly satisfied with being pharmacist. Conclusion Low levels of job satisfaction which were found among Sudanese community pharmacists could be considered as a deficiency of health system in Sudan. Fortunately, inherent interest in the pharmacy profession found among Sudanese pharmacists is an optimistic point at which policy-makers could develop their modifying policies. Health policy-makers must endeavor to take other steps to issue solutions for this current problem.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-19-3066
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2019
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  • 8
    Online Resource
    Online Resource
    Analgesic and Anti-Pyretic Activities of the Root Bark of Rutidea Parviflora (Rubiaceae)
    Open Access Pub ; 2021
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 4 ( 2021-4-6), p. 26-39
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 4 ( 2021-4-6), p. 26-39
    Abstract: This study aims at investigating the antipyretic activity of different solvent fractions of the root bark of Rutidea parviflora (Rubiaceae). This plant is used ethno-botanically by the people of Ethiope East-West Local Government Area of Delta State, Nigeria to treat various ailments such as inflammation, fever and pain. This necessitated this research to validate its local use, due to the scanty literature and information present about this plant. It has also shown some anti-cancer and anti-inflammatory activity in previous researches. The present study is a randomized control study. Acetic acid induced writhing was employed for analgesic testing. Acetic acid was used to induce writhing in Wistar rats which were divided into fourteen (14) groups. The groups were administered extracts and fractions of the plant (200 mg/kg and 400 mg/kg). The animals were observed for number of writing movements and the percentage writhing was calculated. Baker’s yeast induced pyrexia was employed for the antipyretic testing. The animal groups were administered extracts and fractions of the plant (200 mg/kg and 400 mg/kg), with Paracetamol as the standard drug (100 mg/kg) and Normal saline (control) for both experiments. The body temperature of the rats was measured rectally over a period of five (5) hours. All values of P 〈 0.05 were taken as significant. The organic extract, aqueous extract and various fractions (n-hexane, ethyl-acetate, n-butanol and aqueous) produced significant inhibition of writhing responses and pyrexia in a dose dependent manner and time dependent manner respectively. The aqueous extract at a dose of 400mg/kg showed the greatest reduction in writhing, 91.58% compared to the standard drug (paracetamol) which may suggest that the fraction possesses better efficacy than paracetamol as an analgesic. The observed activities could be attributed to these bioactive compounds: Palmatine, Urs-12-ene-24-oic-3-oxo-methyl ester and Gallic acid contained in R. parviflora.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-21-3778
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2021
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  • 9
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    Online Resource
    Investigation on the Impact of Biofield Energy Treatment on the Physical, Thermal and Spectroscopic Characteristics of Zinc Chloride
    Open Access Pub ; 2021
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 4 ( 2021-2-10), p. 11-25
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 4 ( 2021-2-10), p. 11-25
    Abstract: Zinc is an essential trace mineral that plays an important role in the human body as a regulator for different enzymatic systems. It is used in various supplements in the form of zinc chloride to meet the daily requirements. This study was designed with the aim to investigate the impact of The Trivedi Effect®- Energy of Consciousness Healing Treatment on the various physical, thermal, and spectral properties of zinc chloride. The study involves dividing the zinc chloride sample in two parts, followed by keeping the first part untreated and named it the control sample. Besides, The Trivedi Effect®- Biofield Energy Healing Treatment was provided to the other part remotely by the renowned Biofield Energy Healer, Mr. Mahendra Kumar Trivedi and the sample was termed as Biofield Energy Treated sample. Later on, both the samples were analyzed using PXRD, PSA, DSC, UV-Vis, and FT-IR analytical techniques. The PXRD analysis revealed the significant changes in the crystallite sizes (from -66.68% to 25.02%) and the relative peak intensities (from -81.35% to 141.22%) along with 26.46% decrease in the average crystallite size of the Biofield Energy Treated sample, compared with the control sample. Additionally, the treated sample showed reduction in the particle sizes d10, d50, d90, and D(4,3) values by 92.18%, 23.24%, 14.48%, and 29.31%, respectively as compared to the control sample. However, the surface area of the treated sample was observed to be significantly increased by 224.57%, compared to the control sample. The DSC analysis revealed slight increase in the melting and decomposition temperature of the Biofield Energy Treated sample by 0.84% and 3.62%, respectively; along with the significant increase in the latent heat of melting and decomposition by 24.85% and 123.23%, respectively, compared to the control sample. It showed that the thermal stability of the treated sample was significantly increased. However, the UV-Vis and FT-IR studies revealed that the structural properties of the control and treated samples were remained same. The overall study represents that The Trivedi Effect®- Energy of Consciousness Healing Treatment may be used to generate a polymorphic form of zinc chloride, which might possess enhanced solubility, dissolution and bioavailability profile along with improved thermal stability, compared to the control sample. Such properties of the treated zinc chloride may ensure its efficacy, stability and safety during the process of shipment, handling, and storage; thus, The Trivedi Effect®-Energy of Consciousness Healing Treated zinc chloride would be useful for designing the better formulation with enhanced bioavailability, stability and efficacy profile.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-21-3715
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2021
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  • 10
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    Online Resource
    Evaluation of Acacia- Guar Gum Combination as Delayed Release Coating Former on Solid Placebo Tablets
    Open Access Pub ; 2021
    In:  Journal of Advanced Pharmaceutical Science And Technology Vol. 2, No. 4 ( 2021-2-12), p. 1-10
    Details
    In: Journal of Advanced Pharmaceutical Science And Technology, Open Access Pub, Vol. 2, No. 4 ( 2021-2-12), p. 1-10
    Abstract: Objectives The present study addresses evaluation of acacia-guar gum combination as an enteric former for tablet coating aiming to add knowledge on how develop the ability of enteric forming ability of acacia-guar combination. Methods Five formulations of enteric coating solution incorporating guar gum as delayed release polymers along with film coating material acacia gum followed by CMC and glycerin as plasticizer and coloring agents were prepared to coat placebo tablet cores. Different enteric coating formulations organized in different acacia : guar gum ratios as 1:1, 1:2, 1:3, 1:4 and 1:6 were sprayed on placebo tablets surface resulted different delayed coated tablets (F1,F2,F3,F4 & F5) respectively. General appearance and physical parameters were evaluated of each. Enteric coated tablets that revealed promising properties were subjected to accelerated stability study for 3 months to explore the influences of physical aging on tablet coat properties. Results Physical parameters of enteric coated tablets post coating within the range of pharmacopeia specification. The disintegration test was carried out in pH 1.2 and pH 6.8 at 37ºC. F1, F2 and F3 enteric tablets disintegrated immediately with no acid resistance compared F4 and F5 enteric tablets showed good acid resistance coat with smooth tablet surfaces and no coat defects. F5 formula contain acacia: guar gum as 1:6 ratio showed delayed release for 30min in pH 1.2 and 15min in phosphate buffer. The study statistically analyzed and concluded that, an efficient and stable acacia-guar enteric coat is achievable with no effect on tablets physical parameters. Guar gum at 60% as a delayed tablet coating material capable of protecting the tablets core from being released in acidic media and be release in the alkaline buffer as well as stable coat under accelerated storage for three months.
    Type of Medium: Online Resource
    ISSN: 2328-0182
    URL: Journal
    URL: Article
    DOI: 10.14302/issn.2328-0182
    DOI: 10.14302/issn.2328-0182.japst-21-3700
    Language: English
    Publisher: Open Access Pub
    Publication Date: 2021
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