In:
Angewandte Chemie, Wiley, Vol. 132, No. 33 ( 2020-08-10), p. 14102-14106
Abstract:
An asymmetric copper‐catalyzed Sonogashira type coupling between alkynes and α‐bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ‐alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species .
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v132.33
DOI:
10.1002/ange.202000860
Language:
English
Publisher:
Wiley
Publication Date:
2020
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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