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  • 1
    Online Resource
    Online Resource
    Quercetin Mediates β-Catenin in Pancreatic Cancer Stem-Like Cells
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Pancreas Vol. 44, No. 8 ( 2015-11), p. 1334-1339
    Details
    In: Pancreas, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 8 ( 2015-11), p. 1334-1339
    Type of Medium: Online Resource
    ISSN: 0885-3177
    URL: Article
    DOI: 10.1097/MPA.0000000000000400
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
    detail.hit.zdb_id: 2053902-2
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  • 2
    Online Resource
    Online Resource
    A New Risk Model based on the Machine Learning Approach for Prediction of Mortality in the Respiratory Intensive Care Unit
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Pharmaceutical Biotechnology Vol. 24, No. 13 ( 2023-11), p. 1673-1681
    Details
    In: Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 24, No. 13 ( 2023-11), p. 1673-1681
    Abstract: Intensive care unit (ICU) resources are inadequate for the large population in China, so it is essential for physicians to evaluate the condition of patients at admission. In this study, our objective was to construct a machine-learning risk prediction model for mortality in respiratory intensive care units (RICUs). Methods: This study involved 817 patients who made 1,063 visits and who were admitted to the RICU from 2012 to 2017. Potential predictors such as demographic information, laboratory results, vital signs and clinical characteristics were considered. We constructed eXtreme Gradient Boosting (XGBoost) models and compared performances with random forest models, logistic regression models and clinical scores such as Acute Physiology and Chronic Health Evaluation II (APACHE II) and the sequential organ failure assessment (SOFA) system. The model was externally validated using data from Medical Information Mart for Intensive Care (MIMIC-III) database. A web-based calculator was developed for practical use. Results: Among the 1,063 visits, the RICU mortality rate was 13.5%. The XGBoost model achieved the best performance with the area under the receiver operating characteristics curve (AUROC) of 0.860 (95% confidence interval (CI): 0.808 - 0.909) in the test set, which was significantly greater than APACHE II (0.749, 95% CI: 0.674 - 0.820; P = 0.015) and SOFA (0.751, 95% CI: 0.669 - 0.818; P = 0.018). The Hosmer-Lemeshow test indicated a good calibration of our predictive model in the test set with a P-value of 0.176. In the external validation dataset, the AUROC of XGBoost model was 0.779 (95% CI: 0.714 - 0.813). The final model contained variables that were previously known to be associated with mortality, but it also included some features absent from the clinical scores. The mean N-terminal pro-B-type natriuretic peptide (NTproBNP) of survivors was significantly lower than that of the non-survival group (2066.43 pg/mL vs. 8232.81 pg/mL; P 〈 0.001). Conclusions: Our results showed that the XGBoost model could be a suitable model for predicting RICU mortality with easy-to-collect variables at admission and help intensivists improve clinical decision-making for RICU patients. We found that higher NT-proBNP can be a good indicator of poor prognosis.
    Type of Medium: Online Resource
    ISSN: 1389-2010
    URL: Article
    DOI: 10.2174/1389201024666230220103755
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Silver Nanoparticles Based Ink with Moderate Sintering in Flexible and Printed Electronics
    MDPI AG ; 2019
    In:  International Journal of Molecular Sciences Vol. 20, No. 9 ( 2019-04-29), p. 2124-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 20, No. 9 ( 2019-04-29), p. 2124-
    Abstract: Printed electronics on flexible substrates has attracted tremendous research interest research thanks its low cost, large area production capability and environmentally friendly advantages. Optimal characteristics of silver nanoparticles (Ag NPs) based inks are crucial for ink rheology, printing, post-print treatment, and performance of the printed electronics devices. In this review, the methods and mechanisms for obtaining Ag NPs based inks that are highly conductive under moderate sintering conditions are summarized. These characteristics are particularly important when printed on temperature sensitive substrates that cannot withstand sintering of high temperature. Strategies to tailor the protective agents capping on the surface of Ag NPs, in order to optimize the sizes and shapes of Ag NPs as well as to modify the substrate surface, are presented. Different (emerging) sintering technologies are also discussed, including photonic sintering, electrical sintering, plasma sintering, microwave sintering, etc. Finally, applications of the Ag NPs based ink in transparent conductive film (TCF), thin film transistor (TFT), biosensor, radio frequency identification (RFID) antenna, stretchable electronics and their perspectives on flexible and printed electronics are presented.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms20092124
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Longitudinal Relationship between Bullying Victimization and Non-Suicidal Self-Injury among Chinese Adolescents: The Buffering Roles of Gratitude and Parental Autonomy Support
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 2 ( 2023-01-12), p. 1440-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 2 ( 2023-01-12), p. 1440-
    Abstract: Drawing on the resilience-oriented socioecological framework, the current study contributes to scarce scholarship by exploring intrapersonal (i.e., gratitude) and interpersonal (i.e., parental autonomy support) factors in the longitudinal association between bullying victimization and adolescent non-suicidal self-injury (NSSI). Participants were 238 Chinese adolescents (Mage at Time 1 (T1) = 13.45 years; 106 girls and 132 boys) based on a two-wave prospective design with data spanning one year. At T1, adolescents self-rated all study variables, and at Time 2 (T2), youth again reported their NSSI. The results showed a significant main effect (b = 0.12, SE = 0.05, p = 0.04), indicating that bullying victimization was positively related to T2 NSSI one year later, even controlling for T1 NSSI. Moderation analyses further indicated that parental autonomy support buffered against the positive association between bullying victimization and T2 NSSI, but only when adolescents experienced lower levels of gratitude. Specifically, for adolescents with lower levels of gratitude, high levels of parental autonomy support, in a compensatory way, prevented adolescents from NSSI after victimization occurred (b = −0.03, SE = 0.09, p = 0.78); by contrast, for those with higher levels of gratitude, bullying victimization was not significantly related to T2 NSSI, regardless of the levels of parental autonomy support (b = 0.07, SE = 0.04, p = 0.59 for higher parental autonomy support; b = 0.01, SE = 0.07, p = 0.93 for lower parental autonomy support). These findings suggest that gratitude and parental autonomy support, manifesting in a compensatory interaction pattern, could serve as targeted agents for breaking the vicious linkage between bullying victimization and NSSI.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph20021440
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
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  • 5
    Online Resource
    Online Resource
    Glargine insulin/gliclazide MR combination therapy is more effective than premixed insulin monotherapy in Chinese patients with type 2 diabetes inadequately controlled on oral antidiabetic drugs
    Wiley ; 2015
    In:  Diabetes/Metabolism Research and Reviews Vol. 31, No. 7 ( 2015-10), p. 725-733
    Details
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 31, No. 7 ( 2015-10), p. 725-733
    Abstract: The aim of this study is to compare the efficacy and safety of once‐daily insulin glargine plus gliclazide modified release combination therapy versus twice‐daily premixed insulin monotherapy in Chinese type 2 diabetic patients insufficiently controlled by oral antidiabetic agents. Methods In a 12‐week, multicenter, randomized, parallel‐group clinical trial, patients with poor glycaemic control (fasting plasma glucose ≥ 7.0 mmol/L and 7.5%  〈  haemoglobin A 1c  ≤ 10%) on oral antidiabetic drugs were randomized to the treatment groups for combination therapy ( n  = 52) or monotherapy ( n  = 53). Continuous glucose monitoring was carried out over two 72‐h periods, at the beginning and the end of the study, and the data were used to calculate the 24‐h mean blood glucose, mean amplitude of glycaemic excursions, standard deviation of blood glucose, and the mean of daily differences. Results The mean haemoglobin A 1c decrease from baseline to study end was significant for both treatment groups (combination therapy: −1.23 ± 0.92%; insulin monotherapy: −1.02 ± 1.04%); moreover, the combination therapy group showed a significantly more robust haemoglobin A 1c decrease ( p  = 0.0308). Both therapies significantly reduced the 24‐h mean blood glucose (both, p   〈  0.001), but neither produced a significant effect on glycaemic variability, calculated as mean amplitude of glycaemic excursions, standard deviation of blood glucose, and mean of daily differences. In addition, the effects on rates of hypoglycaemic episodes were similar between the two therapies. Conclusions Chinese patients with type 2 diabetes inadequately controlled with oral antidiabetic agents attained greater benefit from once‐daily insulin glargine plus gliclazide modified release regimen than from a twice‐daily premixed insulin regimen. Copyright © 2015 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    URL: Article
    DOI: 10.1002/dmrr.v31.7
    DOI: 10.1002/dmrr.2661
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2001565-3
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  • 6
    Online Resource
    Online Resource
    The enhancing effects of molecule X (X = PH 2 Cl, SHCl, ClCl) on chalcogen–chalcogen interactions in cyclic trimers Y···Y···X (Y = SHCl, SeHCl)
    Wiley ; 2017
    In:  International Journal of Quantum Chemistry Vol. 117, No. 8 ( 2017-04-15)
    Details
    In: International Journal of Quantum Chemistry, Wiley, Vol. 117, No. 8 ( 2017-04-15)
    Abstract: The enhancing effects of molecule X (X = PH 2 Cl, SHCl, ClCl) on S···S and Se···Se chalcogen–chalcogen bonds in the cyclic trimers SHCl···SHCl···X and SeHCl···SeHCl···X were investigated by calculations at the MP2/aug‐cc‐pVTZ level. When molecule X is added to the dimer SHCl···SHCl (SeHCl···SeHCl), cyclic trimers are formed. Compared with the dimer, all the cyclic trimers have shorter S···S (Se···Se) lengths, greater electron densities, negative three‐body interaction energies, and larger second‐order perturbation energies. These results indicate that the addition of molecule X strengthens the original S···S (Se···Se) bond. For the SHCl···SHCl···X cyclic trimers, the S···S bond is strongest in SHCl···SHCl···PH 2 Cl, weaker in SHCl···SHCl···SHCl, and weakest in SHCl···SHCl···ClCl. This same trend is observed for the Se···Se bond in SeHCl···SeHCl···X. This means that PH 2 Cl provides the greatest enhancement to the S···S (Se···Se) interaction.
    Type of Medium: Online Resource
    ISSN: 0020-7608 , 1097-461X
    URL: Issue
    URL: Article
    DOI: 10.1002/qua.v117.8
    DOI: 10.1002/qua.25354
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1475014-4
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  • 7
    Online Resource
    Online Resource
    There Is a Third Condition Aside from Survival and Death that Affects Outcome Statistics: Terminal Discharge
    Knowledge E DMCC ; 2021
    In:  Iranian Journal of Public Health ( 2021-07-28)
    Details
    In: Iranian Journal of Public Health, Knowledge E DMCC, ( 2021-07-28)
    Abstract: Background: Some patients discharged automatically are classified as terminal discharge, while their clinical outcome is survival, disrupting the results of clinical research. Methods: The data of this study were taken from inpatients admitted to the ICU of the First Medical Center of the People's Liberation Army General Hospital, Beijing, China from 2008-2017. We collected the data regarding medications used over the three days before discharge from the group of patients who survived and the group of patients who died, and the outcomes of all patients were recalculated by three classification algorithms (AdaBoosting, Pearson correlation coefficient, observed to expected ratio-weighted cosine similarity). Our basic assumption is that if the classification result is death but the actual in-hospital outcome is survival, the associated patient was likely terminally discharged. Results: The coincidence rate of the outcomes calculated by the AdaBoosting algorithm was 98.1%, the coincidence rate calculated by the Pearson correlation coefficient was 61.1%, and the coincidence rate calculated by the observed to expected ratio-weighted cosine similarity was 93.4%. When the three classification methods were combined, the accuracy reached 98.56%. Conclusion: The combination of clinical rules and classification methods has a synergistic effect on judgments of patients’ discharge outcomes, greatly saving time on manual retrieval and reducing the negative influence of statistics or rules.
    Type of Medium: Online Resource
    ISSN: 2251-6093 , 2251-6085
    URL: Article
    DOI: 10.18502/ijph.v50i8.6809
    Language: Unknown
    Publisher: Knowledge E DMCC
    Publication Date: 2021
    detail.hit.zdb_id: 2240935-X
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  • 8
    Online Resource
    Online Resource
    Manipulating the Macroscopic and Microscopic Morphology of Large‐Area Gravure‐Printed ZnO Films for High‐Performance Flexible Organic Solar Cells
    Wiley ; 2023
    In:  ENERGY & ENVIRONMENTAL MATERIALS
    Details
    In: ENERGY & ENVIRONMENTAL MATERIALS, Wiley
    Abstract: Gravure printing is a promising large‐scale fabrication method for flexible organic solar cells (FOSCs) because it is compatible with two‐dimension patternable roll‐to‐roll fabrication. However, the unsuitable rheological property of ZnO nanoinks resulted in unevenness and looseness of the gravure‐printed ZnO interfacial layer. Here we propose a strategy to manipulate the macroscopic and microscopic of the gravure‐printed ZnO films through using mixed solvent and poly(vinylpyrrolidone) (PVP) additive. The regulation of drying speed effectively manipulates the droplets fusion and leveling process and eliminates the printing ribbing structure in the macroscopic morphology. The additive of PVP effectively regulates the rheological property and improves the microscopic compactness of the films. Following this method, large‐area ZnO:PVP films (28 × 9 cm 2 ) with excellent uniformity, compactness, conductivity, and bending durability were fabricated. The power conversion efficiencies of FOSCs with gravure‐printed AgNWs and ZnO:PVP films reached 14.34% and 17.07% for the 1 cm 2 PM6:Y6 and PM6:L8‐BO flexible devices. The efficiency of 17.07% is the highest value to date for the 1 cm 2 FOSCs. The use of mixed solvent and PVP addition also significantly enlarged the printing window of ZnO ink, ensuring high‐quality printed thin films with thicknesses varying from 30 to 100 nm.
    Type of Medium: Online Resource
    ISSN: 2575-0356 , 2575-0356
    URL: Article
    DOI: 10.1002/eem2.12592
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2945579-0
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  • 9
    Online Resource
    Online Resource
    Flexible CMOS-Like Circuits Based on Printed P-Type and N-Type Carbon Nanotube Thin-Film Transistors
    Wiley ; 2016
    In:  Small Vol. 12, No. 36 ( 2016-09), p. 5066-5073
    Details
    In: Small, Wiley, Vol. 12, No. 36 ( 2016-09), p. 5066-5073
    Type of Medium: Online Resource
    ISSN: 1613-6810
    URL: Article
    DOI: 10.1002/smll.201600452
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2168935-0
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  • 10
    Online Resource
    Online Resource
    Nano-Silver Ink of High Conductivity and Low Sintering Temperature for Paper Electronics
    Springer Science and Business Media LLC ; 2019
    In:  Nanoscale Research Letters Vol. 14, No. 1 ( 2019-12)
    Details
    In: Nanoscale Research Letters, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2019-12)
    Type of Medium: Online Resource
    ISSN: 1931-7573 , 1556-276X
    URL: Article
    DOI: 10.1186/s11671-019-3011-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2253244-4
    detail.hit.zdb_id: 3149496-1
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