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  • 1
    In: The American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, Vol. 105, No. 4 ( 2021-10-06), p. 1067-1075
    Abstract: Routine assessment of the efficacy of artemisinin-based combination therapies (ACTs) is critical for the early detection of antimalarial resistance. We evaluated the efficacy of ACTs recommended for treatment of uncomplicated malaria in five sites in Democratic Republic of the Congo (DRC): artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ), and dihydroartemisinin-piperaquine (DP). Children aged 6–59 months with confirmed Plasmodium falciparum malaria were treated with one of the three ACTs and monitored. The primary endpoints were uncorrected and polymerase chain reaction (PCR)-corrected 28-day (AL and ASAQ) or 42-day (DP) cumulative efficacy. Molecular markers of resistance were investigated. Across the sites, uncorrected efficacy estimates ranged from 63% to 88% for AL, 73% to 100% for ASAQ, and 56% to 91% for DP. PCR-corrected efficacy estimates ranged from 86% to 98% for AL, 91% to 100% for ASAQ, and 84% to 100% for DP. No pfk13 mutations previously found to be associated with ACT resistance were observed. Statistically significant associations were found between certain pfmdr1 and pfcrt genotypes and treatment outcome. There is evidence of efficacy below the 90% cutoff recommended by WHO to consider a change in first-line treatment recommendations of two ACTs in one site not far from a monitoring site in Angola that has shown similar reduced efficacy for AL. Confirmation of these findings in future therapeutic efficacy monitoring in DRC is warranted.
    Type of Medium: Online Resource
    ISSN: 0002-9637 , 1476-1645
    Language: Unknown
    Publisher: American Society of Tropical Medicine and Hygiene
    Publication Date: 2021
    detail.hit.zdb_id: 1491674-5
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  • 2
    In: Indian Journal of Community Medicine, Medknow, Vol. 49, No. Suppl 1 ( 2024-04), p. S20-S20
    Abstract: Mental illness poses a significant global health burden, with negative attitudes towards mental illness contributing to treatment gaps and disparities in care. Understanding the attitudes and perceptions of medical students towards psychiatry and psychiatric illness is crucial for addressing these challenges. This study aimed to assess attitudes and perceptions among undergraduate medical students in an Indian medical college, particularly focusing on the impact of clinical exposure to psychiatry. Methodology: A cross-sectional survey was conducted among 440 MBBS undergraduate students using a composite questionnaire comprising sections on demographics, attitudes towards mental illness and psychiatry, perceived need for mental health support, perceptions of treatment effectiveness, and interest in pursuing psychiatry. Data were analyzed using SPSS version 29. Results: Overall, students exhibited a negative attitude towards mental illness based on the Opinion of Mental Illness (OMI) scale, particularly in factors such as Authoritarianism, Benevolence, and Interpersonal Aetiology. However, exposure to clinical psychiatry postings led to a significant improvement in attitudes. Despite positive attitudes towards psychiatry as a specialty, attitudes towards its inclusion in the curriculum were less positive after clinical exposure. There was significant support for peer counselling among students. Conclusion: The study highlights the importance of clinical exposure in shaping attitudes towards psychiatry among medical students. Efforts should be made to address negative perceptions and enhance the integration of psychiatry in undergraduate medical education. The potential for peer counselling also signifies a need for supportive mental health services within medical colleges. Addressing these issues is essential for fostering a more positive attitude towards mental illness and psychiatry among future physicians.
    Type of Medium: Online Resource
    ISSN: 0970-0218 , 1998-3581
    Language: English
    Publisher: Medknow
    Publication Date: 2024
    detail.hit.zdb_id: 2085330-0
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