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  • 1
    Online Resource
    Online Resource
    Response of Contrasting Nutrient Management Regimes on Soil Aggregation, Aggregate-Associated Carbon and Macronutrients in a 43-Year Long-Term Experiment
    MDPI AG ; 2023
    In:  Sustainability Vol. 15, No. 3 ( 2023-02-02), p. 2679-
    Details
    In: Sustainability, MDPI AG, Vol. 15, No. 3 ( 2023-02-02), p. 2679-
    Abstract: The present investigation evaluated the effect of continuous application ( 〉 43 years) of organic and inorganic fertilisers on soil aggregate stability, aggregate size distribution, aggregate-associated carbon and its fractions, and total macro-nutrient content under the soybean–wheat cropping system in vertisols of the semi-arid region. Seven contrasting treatments consisted of T1 (50% NPK), T2 (100% NPK), T3 (150% NPK), T4 (100% NP), T5 (100% N), T6 (100% NPK + FYM) and T7 Control (crop raised without addition of any nutrient). The highest and lowest percentage of large macroaggregates (11.3%) was found in T6 and T7 treatments. The NPK + FYM (T6) treatments substantially increased the proportion of the macroaggregate fractions ( 〉 2 mm and 2–0.25 mm) than other treatments. However, different manure and fertilisation treatments did not affect the proportion of silt + clay aggregates. Long-term application of 100% NPK + FYM increased mean weight diameter (MWD) and stable water aggregates (WSA) by 35.7 and 6.01% over control. The aggregate-associated SOC followed the trend of large macroaggregates 〉 microaggregates 〉 small macroaggregates 〉 silt + clay fractions. Application of long-term manure plus inorganic fertiliser (T6) has also increased Walkley Black soil organic carbon (WBSC), permanganate oxidisable carbon (KMnO4-C), soil microbial biomass carbon (SMBC), carbon mineralisation (CM), total soil carbon (TSC), total soil N (TSN), total soil phosphorus (TSP) and total soil potassium (STK) by 82.1, 71.6, 182, 42.4, 23.9, 41.6, 117 and 18.4%, respectively, over control (T7). The lowest metabolic quotient (MetQ) value of 5.13 mg CO2–C mg−1 MBC h−1 was obtained in the control treatment (T7). The lowest MetQ was recorded in the integrated application of manure + inorganic fertiliser, i.e., 100% NPK + FYM (T6). Similarly, microbial quotient (MiQ) was also higher in treatment T6 (100% NPK + FYM) and lower in T7 (control). It is concluded that the application of inorganic fertiliser alone is insufficient to maintain soil health and sustainability so, combined application of manure plus inorganic fertilisation is the most important nutrient management practice for long-term soil sustainability because it maintains SOC levels in soils for long periods and ultimately ensures the soil health of soybean–wheat cropping systems in the vertisols of semi-arid regions.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su15032679
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518383-7
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  • 2
    Online Resource
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    International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
    Elsevier BV ; 2022
    In:  Epilepsy & Behavior Vol. 127 ( 2022-02), p. 108502-
    Details
    In: Epilepsy & Behavior, Elsevier BV, Vol. 127 ( 2022-02), p. 108502-
    Type of Medium: Online Resource
    ISSN: 1525-5050
    URL: Article
    DOI: 10.1016/j.yebeh.2021.108502
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2018844-4
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  • 3
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    Platelet FcγRIIa Expression in Ischemic Stroke: A Marker of Increased Platelet Reactivity
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Stroke: Vascular and Interventional Neurology Vol. 2, No. 3 ( 2022-05)
    Details
    In: Stroke: Vascular and Interventional Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 3 ( 2022-05)
    Abstract: Platelet FcγRIIa amplifies platelet activation and, thus, increased expression identifies patients with increased platelet reactivity. Previous work has demonstrated that platelet FcγRIIa can identify patients at high and low risk of subsequent cardiovascular events after myocardial infarction (MI). This study was designed to compare platelet expression of FcγRIIa in patients with stroke and transient ischemic attack (TIA) with that in patients with a recent MI. Methods Patients were enrolled based on an admitting diagnosis of stroke/TIA, and the discharge diagnosis was used to categorize patients into stroke/TIA (n=99) and other causes of neurologic dysfunction (hemorrhagic, trauma, toxic, and seizure; n=14). Patients with stroke/TIA were divided into embolic (both cardioembolic and thromboembolic; n=32) and not embolic causes (n=67). Results were compared with platelet FcγRIIa expression in patients with recent MI from a previous study (n=197). Platelet expression of FcγRIIa (molecules of FcγRIIa/platelet) was quantified with the use of flow cytometry. Results are mean±SD. Results Platelet expression of FcγRIIa was similar in patients with ischemic (both embolic and nonembolic) stroke/TIA (11 332±4127), embolic (11 204±3889) and nonembolic (11 393±4263) causes, and MI (11 479±2405). Patients with other causes of neurologic dysfunction had modestly but not significantly lower platelet expression of FcγRIIa (9389±2883; P =0.13). Conclusions Platelet expression of FcγRIIa was similar in patients with stroke/TIA and recent MI. These results support future studies designed to determine whether platelet FcγRIIa expression can discriminate risk of subsequent stroke/TIA and its potential use as a precision tool capable of guiding individualized treatment decisions.
    Type of Medium: Online Resource
    ISSN: 2694-5746
    URL: Article
    DOI: 10.1161/SVIN.121.000201
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 3144224-9
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  • 4
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    Abstract TP229: Impact Of Genetic Polymorphisms On The Risk Of Epilepsy Amongst Patients With Acute Brain Injury: A Systematic Review
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Stroke Vol. 54, No. Suppl_1 ( 2023-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. Suppl_1 ( 2023-02)
    Abstract: Introduction: Stroke and traumatic brain injury (TBI) accounts for 70% of secondary epilepsy in the adult population. The genetic architecture of epilepsy secondary to TBI or stroke is poorly understood. Objective: We undertook a systematic review to test the association of single nucleotide polymorphisms (SNPs) with the risk of posttraumatic epilepsy (PTE) and post-stroke epilepsy (PSE). Methods: We conducted a comprehensive literature search until 5 July 2022 in PubMed, Embase, PsycINFO, Web of Science, and Google Scholar. We preregistered the protocol of this systematic review on PROSPERO (CRD42022325617). We collated the association statistics from the articles to assess the association of SNPs with the risk of epilepsy amongst TBI or stroke patients. We assessed the study quality using the Quality of Genetic Association (Q-Genie) tool. We report Odds Ratio (OR) and Hazard Ratio (HR) with a 95% confidence interval (CI), including combined OR where a meta-analysis was possible. Results: The literature search yielded 420 articles, of which 16 were included in our systematic review. Q-Genie-based assessment of the literature found that 58% of the included studies were of poor quality. We examined published data on 127 SNPs from 32 genes identified in PTE and PSE patients. Twelve studies reported that 718 TBI patients (21%) suffered from PTE. Four studies reported PSE in 1192 stroke patients (50%). Eleven SNPs were associated with an increased risk of PTE. Three SNPs, TRMP6 rs2274924, ALDH2 rs671, CD40 -1C/T, were significantly associated with an increased risk of PSE, while two SNPs, AT1R rs12721273 and rs55707609, were significantly associated with reduced risk. Only two studies tested the association of APOE E4 with PTE; no other studies validated previously reported genetic association data. Hence, the limited data precluded meta-analysis of all but one SNP, i.e., the APOE E4 allele. The meta-analysis for the association of the APOE E4 allele with PTE was non-significant (OR 1.8, CI 0.6-5.6). Conclusions: The current evidence on the association of genetic polymorphisms in epilepsy secondary to TBI or stroke is of low quality and lacks validation. A collaborative effort to pool genetic data linked to epileptogenesis in stroke and TBI patients is warranted.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.54.suppl_1.TP229
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1467823-8
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  • 5
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    Postthrombolysis Outcomes in Acute Ischemic Stroke Patients of Asian Race-Ethnicity
    SAGE Publications ; 2013
    In:  International Journal of Stroke Vol. 8, No. SA100 ( 2013-10), p. 95-99
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 8, No. SA100 ( 2013-10), p. 95-99
    Abstract: Race-ethnic differences may influence postthrombolysis outcomes in acute ischemic stroke patients. Guidelines for thrombolytic therapy to treat Asian stroke patients are based mostly on extrapolated western data. Aims We undertook to examine outcomes among Asians by comparing a propensity-matched cohort of thrombolyzed patients from a tertiary center in Singapore with nonthrombolyzed Asian comparators collated from Virtual International Stroke Trials Archives (control). Methods We identified propensity scores-matched patients between thrombolyzed and control Asian patients lodged in the Virtual International Stroke Trials Archives by employing propensity scores method. We compared matched patients for their distributions of three-month functional (modified Rankin scores) and neurological outcomes (National Institute of Health Stroke Scale) by employing Cochran–Mantel–Haenszel test and proportional odds logistic regression analysis. We report odds ratio and 95% confidence interval for improved outcomes on day 90. Results Virtual International Stroke Trials Archives and National University Hospital, Singapore, contributed 517 and 133 patients of Asian race-ethnicity ( n = 650), respectively. After propensity matching, sample size reduced to 237 patients; 104 were from Virtual International Stroke Trials Archives. Age (59·7 vs. 61·5 years, P = 0·2) and mean baseline National Institute of Health Stroke Scale scores were similar ( 14 ) between thrombolyzed and control. The odds ratio for shift toward improved modified Rankin scores and National Institute of Health Stroke Scale distributions after tissue plasminogen activator therapy were 2·8 (95% confidence interval 1·8–4·5, P 〈 0·0001, n = 233; Cochran–Mantel–Haenszel P 〈 0·0001) and 2·8 (95% confidence interval 1·7–4·7, P = 0·0008, n = 201; Cochran–Mantel–Haenszel P = 0·0001). Conclusions Our data indicate that Asian patients derive benefit from thrombolytic therapy.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1111/ijs.12012
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2211666-7
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  • 6
    Online Resource
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    Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review
    Wiley ; 2023
    In:  European Journal of Neurology Vol. 30, No. 6 ( 2023-06), p. 1791-1800
    Details
    In: European Journal of Neurology, Wiley, Vol. 30, No. 6 ( 2023-06), p. 1791-1800
    Abstract: The genetics of late seizure or epilepsy secondary to traumatic brain injury (TBI) or stroke are poorly understood. We undertook a systematic review to test the association of single‐nucleotide polymorphisms (SNPs) with the risk of post‐traumatic epilepsy (PTE) and post‐stroke epilepsy (PSE). Methods We followed methods from our prespecified protocol on PROSPERO to identify indexed articles for this systematic review. We collated the association statistics from the included articles to assess the association of SNPs with the risk of epilepsy amongst TBI or stroke patients. We assessed study quality using the Q‐Genie tool. We report odds ratios (OR) and hazard ratios with 95% confidence intervals (CIs). Results The literature search yielded 420 articles. We included 16 studies in our systematic review, of which seven were of poor quality. We examined published data on 127 SNPs from 32 genes identified in PTE and PSE patients. Eleven SNPs were associated with a significantly increased risk of PTE. Three SNPs, TRMP6 rs2274924, ALDH2 rs671, and CD40 ‐1C/T, were significantly associated with an increased risk of PSE, while two, AT1R rs12721273 and rs55707609, were significantly associated with reduced risk. The meta‐analysis for the association of the APOE ɛ4 with PTE was nonsignificant (OR 1.8, CI 0.6–5.6). Conclusions The current evidence on the association of genetic polymorphisms in epilepsy secondary to TBI or stroke is of low quality and lacks validation. A collaborative effort to pool genetic data linked to epileptogenesis in stroke and TBI patients is warranted.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v30.6
    DOI: 10.1111/ene.15777
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020241-6
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  • 7
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    Online Resource
    Editorial: Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke
    Frontiers Media SA ; 2021
    In:  Frontiers in Neurology Vol. 12 ( 2021-8-31)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 12 ( 2021-8-31)
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    DOI: 10.3389/fneur.2021.745993
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2564214-5
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  • 8
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    A Score Based on Age and DWI Volume Predicts Poor Outcome following Endovascular Treatment for Acute Ischemic Stroke
    SAGE Publications ; 2015
    In:  International Journal of Stroke Vol. 10, No. 5 ( 2015-07), p. 705-709
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 10, No. 5 ( 2015-07), p. 705-709
    Abstract: The Houston Intra-Arterial Therapy score predicts poor functional outcome following endovascular treatment for acute ischemic stroke based on clinical variables. The present study sought to (a) create a predictive scoring system that included a neuroimaging variable and (b) determine if the scoring systems predict the clinical response to reperfusion. Methods Separate datasets were used to derive ( n = 110 from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 study) and validate ( n= 125 from Massachusetts General Hospital) scoring systems that predict poor functional outcome, defined as a modified Rankin Scale score of 4–6 at 90 days. Results Age ( P 〈 0·001; β = 0·087) and diffusion-weighted imaging volume ( P= 0·023; β = 0·025) were the independent predictors of poor functional outcome. The Stanford Age and Diffusion-Weighted Imaging score was created based on the patient's age (0–3 points) and diffusion-weighted imaging lesion volume (0–1 points). The percentage of patients with a poor functional outcome increased significantly with the number of points on the Stanford Age and Diffusion-Weighted Imaging score ( P 〈 0·01 for trend). The area under the receiver operating characteristic curve for the Stanford Age and Diffusion-Weighted Imaging score was 0·82 in the derivation dataset. In the validation cohort, the area under the receiver operating characteristic curve was 0·69 for the Stanford Age and Diffusion-Weighted Imaging score and 0·66 for the Houston Intra-Arterial Therapy score ( P = 0·45 for the difference). Reperfusion, but not the interactions between the prediction scores and reperfusion, were predictors of outcome ( P 〉 0·5). Conclusions The Stanford Age and Diffusion-Weighted Imaging and Houston Intra-Arterial Therapy scores can be used to predict poor functional outcome following endovascular therapy with good accuracy. However, these scores do not predict the clinical response to reperfusion. This limits their utility as tools to select patients for acute stroke interventions.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1111/ijs.12207
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2211666-7
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  • 9
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    Influence of Racial Differences on Outcomes after Thrombolytic Therapy in Acute Ischemic Stroke
    SAGE Publications ; 2014
    In:  International Journal of Stroke Vol. 9, No. 5 ( 2014-07), p. 613-617
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 9, No. 5 ( 2014-07), p. 613-617
    Abstract: The National Institutes of Neurological Disorders and Stroke and the European Co-operative Acute Stroke III trials enrolled a largely Caucasian population, but the results are often extrapolated onto non-Caucasians. A limited number of nonrandomized studies have proposed that non-Caucasian patients show differential response to tissue plasminogen activator. Aims and/or hypothesis We examined if non-Caucasian patients of mixed national origin within the Virtual International Stroke Trials Archives neuroprotection trials responded differently to tissue plasminogen activator compared with Caucasians. Methods We matched patients within each race-subtype for age, baseline National Institutes of Health Stroke Scales, and diabetes status, and excluded outliers. We tested for an interaction of race ethnicity with tissue plasminogen activator on predicting outcomes at α = 0·05. We compared 90-day ordinal outcome (modified Rankin Scale; primary analysis) and dichotomized outcomes (modified Rankin Scale 0–1; modified Rankin Scale 0–2; survival) within individual race ethnicity. Results One thousand nine hundred forty-six thrombolysed patients (125 Blacks, 39 Asians, and 1821 Caucasians) were matched with 1946 non-thrombolysed patients in each race ethnicity group. Postmatching, there were no imbalances in baseline National Institutes of Health Stroke Scales and age between the groups ( P 〉 0·05). The interaction of tissue plasminogen activator with race ethnicity was nonsignificant in ordinal ( P = 0·4) and in dichotomized outcome models ( P 〉 0·05). Ordinal odds for improved outcomes were 1·5 for all patients ( P 〈 0·05). Ordinal odds for Caucasians were 1·5 ( P 〈 0·05); for Blacks, 2·1 ( P 〈 0·05); and for Asians, 1·2 ( P 〉 0·05; 1·6 after 1:2 matching with nonthrombolysed, because of small numbers). Dichotomized functional outcomes improved after thrombolysis overall, in Caucasians, in Blacks (modified Rankin Scale 0–2 only), and in Asians (after 1:2 matching; P 〉 0·05). Odds for survival were consistent across all groups. Conclusions These results do not suggest a differential response to tissue plasminogen activator based on race ethnicity. Among Asians, data were particularly sparse, and results should be interpreted with caution.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1111/ijs.12162
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2211666-7
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  • 10
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    Comorbid Parkinson's disease, falls and fractures in the 2010 National Emergency Department Sample
    Elsevier BV ; 2017
    In:  Parkinsonism & Related Disorders Vol. 35 ( 2017-02), p. 30-35
    Details
    In: Parkinsonism & Related Disorders, Elsevier BV, Vol. 35 ( 2017-02), p. 30-35
    Type of Medium: Online Resource
    ISSN: 1353-8020
    URL: Article
    DOI: 10.1016/j.parkreldis.2016.11.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2027635-7
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