In:
Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-12-16)
Abstract:
Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance in DLBCL has been poorly explored. Herein, we broadly assessed circulating monocyte heterogeneity in 91 DLBCL patients. Classical- (cMO, CD14 pos CD16 neg ) and intermediate- (iMO, CD14 pos CD16 pos ) monocytes accumulated in DLBCL peripheral blood and exhibited an inflammatory phenotype. On the opposite, nonclassical monocytes (ncMOSlan pos , CD14 low CD16 pos Slan neg and ncMOSlan neg , CD14 low CD16 pos , Slan neg ) were decreased in peripheral blood. Tumor-conditioned monocytes presented similarities with ncMO phenotype from DLBCL and were prone to migrate in response to CCL5 and CXCL12, and presented similarities with DLBCL-infiltrated myeloid cells, as defined by mass cytometry. Finally, we demonstrated the adverse value of an accumulation of nonclassical monocytes in 2 independent cohorts of DLBCL.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2021.755623
DOI:
10.3389/fimmu.2021.755623.s001
DOI:
10.3389/fimmu.2021.755623.s002
DOI:
10.3389/fimmu.2021.755623.s003
DOI:
10.3389/fimmu.2021.755623.s004
DOI:
10.3389/fimmu.2021.755623.s005
DOI:
10.3389/fimmu.2021.755623.s006
DOI:
10.3389/fimmu.2021.755623.s007
DOI:
10.3389/fimmu.2021.755623.s008
DOI:
10.3389/fimmu.2021.755623.s009
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2606827-8
Permalink