In:
Clinical Transplantation, Wiley, Vol. 32, No. 1 ( 2018-01)
Abstract:
At present, several studies have reported that the pretreatment neutrophil‐lymphocyte ratio ( NLR ) may be associated with the prognosis of liver cancer. Nevertheless, their conclusions remain controversial. Thus, we performed a meta‐analysis of 54 studies to evaluate the prognostic value of NLR . Method Databases including PubMed, Embase, Cochrane Library, and Web of Science were searched to July 2017. Result A total of 54 studies including 12 979 patients were included in this meta‐analysis. Elevated NLR had a close relationship with the overall survival ( OS ) ( HR 1.52; 95% CI 1.39‐1.67), recurrence‐free survival ( RFS ) ( HR 1.84; 95% CI 1.48‐2.30), and disease‐free survival ( DFS ) ( HR 1.71; 95% CI 1.39‐2.11) of liver cancer, respectively. In addition, elevated NLR was associated with the presence of tumor vascular invasion ( OR 2.35; 95% CI 1.93‐2.86), multiple tumors ( OR 1.38; 95% CI 1.15‐1.66), alpha‐fetoprotein ≥ 400 ng/mL ( OR 1.51; 95% CI 1.15‐1.98), presence of HbsAg (+) ( OR 0.68; 95% CI 0.51‐0.90), and cirrhosis ( OR : 0.59; 95% CI 0.44‐0.80). Conclusion This meta‐analysis indicated that elevated NLR may be an effective and noninvasive indicator for prognosis of patients with liver cancer.
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2018.32.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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