In:
Pediatric Anesthesia, Wiley, Vol. 24, No. 3 ( 2014-03), p. 322-326
Abstract:
To determine the effects of pretreatment with either promethazine or dexamethasone on mivacurium‐induced histamine release in children. Methods Eighty ASA I–II children (4–10 years of age) scheduled for tonsillectomy and/or adenoidectomy were randomly divided into 4 groups ( n = 20 per group) designated as either the rocuronium, mivacurium, dexamethasone ( DXM ), or promethazine group. Children in the DXM and promethazine groups were treated separately with intramuscular DXM 0.2 mg·kg −1 or promethazine 0.5 mg·kg −1 injections 60 min before operation. Radial artery blood samples were collected to quantify plasma histamine concentrations 1 min before and 1, 3, and 5 min after administration of the relaxant. Mean arterial pressure ( MAP ), heart rate ( HR ), and skin flushing were recorded at the same time. Results No significant decreases in plasma histamine concentrations were observed between groups; however, more stable MAP and HR and less skin flushing were observed in DXM group participants compared with individuals in the mivacurium group ( P 〈 0.05). By contrast, children in the promethazine group had significantly decreased plasma histamine concentrations and stable MAP and HR (without a significant increase in HR ) compared with patients in mivacurium group. In addition, skin flushing was significantly decreased compared with that observed in the rocuronium group ( P 〈 0.05). Conclusions Pretreatment with promethazine significantly decreased mivacurium‐induced histamine release in children and provided stable hemodynamics during administration of anesthesia.
Type of Medium:
Online Resource
ISSN:
1155-5645
,
1460-9592
DOI:
10.1111/pan.2014.24.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2008564-3
Permalink