In:
PLOS Biology, Public Library of Science (PLoS), Vol. 18, No. 11 ( 2020-11-30), p. e3000940-
Abstract:
It is unknown how growth in one tissue impacts morphogenesis in a neighboring tissue. To address this, we used the Drosophila ovarian follicle, in which a cluster of 15 nurse cells and a posteriorly located oocyte are surrounded by a layer of epithelial cells. It is known that as the nurse cells grow, the overlying epithelial cells flatten in a wave that begins in the anterior. Here, we demonstrate that an anterior to posterior gradient of decreasing cytoplasmic pressure is present across the nurse cells and that this gradient acts through TGFβ to control both the triggering and the progression of the wave of epithelial cell flattening. Our data indicate that intrinsic nurse cell growth is important to control proper nurse cell pressure. Finally, we reveal that nurse cell pressure and subsequent TGFβ activity in the stretched cells combine to increase follicle elongation in the anterior, which is crucial for allowing nurse cell growth and pressure control. More generally, our results reveal that during development, inner cytoplasmic pressure in individual cells has an important role in shaping their neighbors.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3000940
DOI:
10.1371/journal.pbio.3000940.g001
DOI:
10.1371/journal.pbio.3000940.g002
DOI:
10.1371/journal.pbio.3000940.g003
DOI:
10.1371/journal.pbio.3000940.g004
DOI:
10.1371/journal.pbio.3000940.g005
DOI:
10.1371/journal.pbio.3000940.g006
DOI:
10.1371/journal.pbio.3000940.g007
DOI:
10.1371/journal.pbio.3000940.s001
DOI:
10.1371/journal.pbio.3000940.s002
DOI:
10.1371/journal.pbio.3000940.s003
DOI:
10.1371/journal.pbio.3000940.s004
DOI:
10.1371/journal.pbio.3000940.s005
DOI:
10.1371/journal.pbio.3000940.s006
DOI:
10.1371/journal.pbio.3000940.s007
DOI:
10.1371/journal.pbio.3000940.s008
DOI:
10.1371/journal.pbio.3000940.s009
DOI:
10.1371/journal.pbio.3000940.s010
DOI:
10.1371/journal.pbio.3000940.s011
DOI:
10.1371/journal.pbio.3000940.s012
DOI:
10.1371/journal.pbio.3000940.s013
DOI:
10.1371/journal.pbio.3000940.r001
DOI:
10.1371/journal.pbio.3000940.r002
DOI:
10.1371/journal.pbio.3000940.r003
DOI:
10.1371/journal.pbio.3000940.r004
DOI:
10.1371/journal.pbio.3000940.r005
DOI:
10.1371/journal.pbio.3000940.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2126773-X
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