In:
Journal of Diabetes Investigation, Wiley, Vol. 7, No. 4 ( 2016-07), p. 607-614
Abstract:
To investigate the impact of increased visceral adiposity with normal weight ( OB [−] VA [+]) on the prevalence of non‐alcoholic fatty liver disease in patients with type 2 diabetes. Materials and Methods This was a cross‐sectional study of 140 Japanese patients with type 2 diabetes (mean age 65 ± 11 year; 44.6% women). Visceral fat area ( VFA ; cm 2 ) and liver attenuation index ( LAI ) were assessed by abdominal computed tomography. The patients were divided into four groups by VFA and body mass index ( BMI ; kg/m 2 ) as follows: BMI 〈 25 kg/m 2 and VFA 〈 100 cm 2 ( OB [−] VA [−]), BMI ≥25 kg/m 2 and VFA 〈 100 cm 2 ( OB [+] VA [−]), BMI 〈 25 kg/m 2 and VFA ≥100 cm 2 ( OB [−] VA [+]), and BMI ≥25 kg/m 2 and VFA ≥100 cm 2 ( OB [+] VA [+]). Multivariate linear regression and logistic regression analysis were carried out to determine the impact of OB (−) VA (+) on LAI . Results In the present study, 25.0% were OB (−) VA (+) patients, where the LAI levels were lower (1.09 ± 0.22) than those in OB (−) VA (−) patients (1.23 ± 0.15), and were equivalent to those in OB (+) VA (+) patients (1.03 ± 0.26). In multivariate linear regression analysis, OB (−) VA (+) was independently associated with LAI (standardized β−0.212, P = 0.014). In multivariate logistic regression analysis, OB (−) VA (+) was a significant predictor of LAI 〈 0.9 (odds ratio 5.88, 95% confidence interval 1.03−33.52, P = 0.046). Conclusions The present study provides evidence that increased visceral adiposity with normal weight is a strong predictor for the prevalence of non‐alcoholic fatty liver disease in Japanese patients with type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
2040-1116
,
2040-1124
DOI:
10.1111/jdi.2016.7.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2542077-X
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