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  • 1
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    Psychometric characteristics of the Serbian version of the Licester Cough Questionnaire in sarcoidosis patients
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2019
    In:  Hospital Pharmacology - International Multidisciplinary Journal Vol. 6, No. 1 ( 2019), p. 728-737
    Details
    In: Hospital Pharmacology - International Multidisciplinary Journal, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 6, No. 1 ( 2019), p. 728-737
    Type of Medium: Online Resource
    ISSN: 2334-9492 , 2334-9492
    Uniform Title: Psihometrijske karakteristike srpske verzije Lesterskog upitnika o kašlju kod bolesnika sa sarkoidozome
    URL: Article
    DOI: 10.5937/hpimj1901728G
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2019
    detail.hit.zdb_id: 3069799-2
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  • 2
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    Comorbidity burden and survival in patients with idiopathic pulmonary fibrosis: the EMPIRE registry study
    Springer Science and Business Media LLC ; 2022
    In:  Respiratory Research Vol. 23, No. 1 ( 2022-12)
    Details
    In: Respiratory Research, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12)
    Abstract: Patients with idiopathic pulmonary fibrosis (IPF) frequently have multiple comorbidities, which may influence survival but go under-recognised in clinical practice. We therefore report comorbidity, antifibrotic treatment use and survival of patients with IPF observed in the multi-national EMPIRE registry. Methods For this prospective IPF cohort, demographics, comorbidities, survival and causes of death were analysed. Comorbidities were noted by the treating physician based on the patient’s past medical history or as reported during follow-up. Comorbidities were defined as prevalent when noted at enrolment, or as incident when recorded during follow-up. Survival was analysed by Kaplan–Meier estimates, log-rank test, and Cox proportional hazards models. Hazard ratios (HR) were adjusted for gender, age, smoking status and FVC at enrolment. Results A population of 3,580 patients with IPF from 11 Central and Eastern European countries was followed every 6 months for up to 6 years. At enrolment, 91.3% of patients reported at least one comorbidity, whereas more than one-third (37.8%) reported four or more comorbidities. Five-year survival was 53.7% in patients with no prevalent comorbidities, whereas it was 48.4%, 47.0%, 43.8% and 41.1% in patients with 1, 2, 3 and ≥ 4 comorbidities, respectively. The presence of multiple comorbidities at enrolment was associated with significantly worse survival (log-rank test P  = 0.007). Adjusted HRs indicate that risk of death was increased by 44% in patients with IPF reporting ≥ 4 comorbidities at baseline compared with no comorbidity ( P  = 0.021). The relationship between number of comorbidities and decreased survival was also seen in patients receiving antifibrotic treatment (63% of all patients; log-rank test P   〈  0.001). Comorbidity as cause of death was identified in at least 26.1% of deaths. Conclusions The majority of patients with IPF demonstrate comorbidities, and many have comorbidity-related deaths. Increasing numbers of comorbidities are associated with worse survival; and this pattern is also present in patients receiving antifibrotic therapy.
    Type of Medium: Online Resource
    ISSN: 1465-993X
    URL: Article
    DOI: 10.1186/s12931-022-02033-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041675-1
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  • 3
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    SEVERITY OF SYMPTOMS AND HEALTH STATUS IN PATIENTS WITH PULMONARY AND EXTRAPULMONARY SARCOIDOSIS
    Elsevier BV ; 2007
    In:  Chest Vol. 132, No. 4 ( 2007-10), p. 587A-
    Details
    In: Chest, Elsevier BV, Vol. 132, No. 4 ( 2007-10), p. 587A-
    Type of Medium: Online Resource
    ISSN: 0012-3692
    URL: Article
    DOI: 10.1378/chest.132.4_MeetingAbstracts.587a
    RVK:
    XA 36340
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2007
    detail.hit.zdb_id: 1032552-9
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  • 4
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    Analsysis of frequency of tuberculosis in smokers
    National Library of Serbia ; 2013
    In:  Medical review Vol. 66, No. suppl. 1 ( 2013), p. 84-87
    Details
    In: Medical review, National Library of Serbia, Vol. 66, No. suppl. 1 ( 2013), p. 84-87
    Abstract: Introduction. Smoking and tuberculosis are among the most important problems of public health. Smoking and tuberculosis are responsible for 5 million and 2 million deaths per year, respectively, whereas smoking is responsible for half a million deaths in patients with tuberculosis. Discussion and Review of Literature. Nicotine is a significant suppressor of function of macrophages, dendritic cells and T-cells, which explains the immunosuppressive features of smoking that help develop the infection. Tobacco smoke contains many substances with immunomodulatory effects, including nicotine, carbon monoxide, acrolein, peroxynitrite and many others. The dominant immune and pathophysiological mechanism is the reduction of synthesis of tumor necrosis factor in lung macrophages, leading to increased susceptibility of persons who are exposed to tobacco smoke for developing active tuberculosis after infection and increased susceptibility to the development of other infections, such as infections of Gram-negative bacteria. Based on epidemiological studies and studies on this problem in the past 50 years, the World Health Organization has published the finding that smoking increases the risk of infection with M. tuberculosis, increases the risk of progression of infection to active disease and the risk of death. The prevalence of tuberculosis is higher in smokers and former smokers than in nonsmokers. The risk of tuberculosis depends on the number of cigarettes smoked and length of period the person has been a smoker. Passive smoking accelerates the development of active tuberculosis. in children who live with persons suffering from active tuberculosis, Conclusion. Given the multiple consequences of the association between smoking and tuberculosis, prevention of smoking may be an important measure in the control of tuberculosis.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS13S1084S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2381028-2
    detail.hit.zdb_id: 131108-6
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  • 5
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    Endobronchial ultrasound in diagnosing sarcoidosis
    National Library of Serbia ; 2013
    In:  Medical review Vol. 66, No. suppl. 1 ( 2013), p. 22-25
    Details
    In: Medical review, National Library of Serbia, Vol. 66, No. suppl. 1 ( 2013), p. 22-25
    Abstract: Introduction. The diagnosis of sarcoidosis can be established when there is a compatible clinical-radiological picture together with pathohistological evidence of noncaseating epitheloid cell granulomas. Novelties in Diagnosis of Sarcoidosis. Pathohistological specimens can be obtained by conventional bronchoscopy with endobronchial and transbronchial lung biopsy, bronchoalveolar lavage, surgical procedures like cervical mediastinoscopy, diagnostic thoracotomy, video-assisted thoracoscopic surgery, and recently introduced endoscopic ultrasound techniques (endoscopic ultrasound-guided fine-needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration). Endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound-guided fine-needle aspiration have given a great contribution to diagnosis of sarcoidosis and present next diagnostic step after negative bronchoscopy. Conclusion. Reduction of surgical procedures in diagnosis of sarcoidosis, can be expected (first of all mediastinoscopy) by introducing endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound-guided fine-needle aspiration.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS13S1022S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2381028-2
    detail.hit.zdb_id: 131108-6
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  • 6
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    Nonsteroid therapy of sarcoidosis
    National Library of Serbia ; 2013
    In:  Medical review Vol. 66, No. suppl. 1 ( 2013), p. 60-66
    Details
    In: Medical review, National Library of Serbia, Vol. 66, No. suppl. 1 ( 2013), p. 60-66
    Abstract: Introduction. Corticosteroid therapy used to be considered a common treatment for sarcoidosis patients. Discussion and Review of Literature. It is known that corticosteroids have many side affects, and that knowledge called for other possible treatments, non-steroidal agents that would allow prolonged treatment of chronic sarcoidosis and avoid side effects of steroids on metabolism, glicoregulation, increase in body weight, osteoporosis, Cushing syndrome etc. There is a wide range of medications that can offer alternative to corticosteroid therapy. So far, none of the agents has been absolutely perfect. Conclusion. Therefore, it can be concluded that every clinician should choose the best possible treatment for each sarcoidosis patient.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS13S1060M
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2381028-2
    detail.hit.zdb_id: 131108-6
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  • 7
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    Treatment of neurosarcoidosis: Innovations and challenges
    National Library of Serbia ; 2014
    In:  Medical review Vol. 67, No. 5-6 ( 2014), p. 161-166
    Details
    In: Medical review, National Library of Serbia, Vol. 67, No. 5-6 ( 2014), p. 161-166
    Abstract: Uvod. Sarkoidoza zahvata centralni nervi sistem cesce nego sto se ranije smatralo. Dok su kranijalni nervi najcesce pogodjeni, neurosarkoidoza moze zahvatiti i druga tkiva nervnog sistema. Terapija neurosarkoidoze. Iako se dosta lekova pokazalo korisnim u lecenju neurosarkoidoze, kortikosteroidi i dalje predstavljaju zlatni standard u lecenju ovih bolesnika. Terapijski rezimi se razlikuju u pogledu doziranja lekova. Simptomatska neurosarkoidoza uvek se leci pulsnim dozama kortikosteroidne terapije. Osobe sa secernom bolesti, povisenim krvnim pritiskom, tuberkulozom i osteoporozom treba pazljivo pratiti, posto su sklone razvoju komplikacija u vezi sa terapijom kortikosteroidima. U slucajevima kada tretman kortikosteroidima ne pokazuje zeljene rezultate ili je terapija prekinuta zbog razvoja nezeljenih efekata, postoje i druge farmakoloske opcije, poput metotreksata, mikofenolat-mofetila, ciklofosfamida, hlorokina, azatioprina, talidomida i infliksimaba. Treba napomenuti da je na navedene terapijske rezime, izuzev infliksimaba, terapijski odgovor relativno spor u odnosu na kortikosteroide - dakle kortikosteroidi treba da se uzmu o obzir u svim stanjima, narocito u akutnoj fazi bolest. Zakljucak. Upravo postojanje razlicitih oblika ovog oboljenja, odsustvo dijagnostickih kriterijuma i razlicita i nestandardizovana terapija cine lecenje ove bolesti tezim. Uprkos napredovanjima u farmakoterapiji i radioloskoj dijagnostici, potrebno je razviti bolje dijagnosticke strategije kako bi se postavio sto optimalniji terapijski pristup.
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS1406161S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
    detail.hit.zdb_id: 2381028-2
    detail.hit.zdb_id: 131108-6
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  • 8
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    Alcohol use and clinical manifestations of tuberculosis
    National Library of Serbia ; 2018
    In:  Srpski arhiv za celokupno lekarstvo Vol. 146, No. 1-2 ( 2018), p. 110-111
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 146, No. 1-2 ( 2018), p. 110-111
    Abstract: nema
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH160901188S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2018
    detail.hit.zdb_id: 2577665-4
    detail.hit.zdb_id: 128567-1
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  • 9
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    Table_3.xlsx
    Frontiers Media SA ; 2023
    In:  Frontiers in Medicine Vol. 10 ( 2023-8-9)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 10 ( 2023-8-9)
    Abstract: Sarcoidosis is a highly variable disease in terms of organ involvement, type of onset and course. Associations of genetic polymorphisms with sarcoidosis phenotypes have been observed and suggest genetic signatures. Methods After obtaining a positive vote of the competent ethics committee we genotyped 1909 patients of the deeply phenotyped Genetic-Phenotype Relationship in Sarcoidosis (GenPhenReSa) cohort of 31 European centers in 12 countries with 116 potentially disease-relevant single-nucleotide polymorphisms (SNPs). Using a meta-analysis, we investigated the association of relevant phenotypes (acute vs. sub-acute onset, phenotypes of organ involvement, specific organ involvements, and specific symptoms) with genetic markers. Subgroups were built on the basis of geographical, clinical and hospital provision considerations. Results In the meta-analysis of the full cohort, there was no significant genetic association with any considered phenotype after correcting for multiple testing. In the largest sub-cohort (Serbia), we confirmed the known association of acute onset with TNF and reported a new association of acute onset an HLA polymorphism. Multi-locus models with sets of three SNPs in different genes showed strong associations with the acute onset phenotype in Serbia and Lublin (Poland) demonstrating potential region-specific genetic links with clinical features, including recently described phenotypes of organ involvement. Discussion The observed associations between genetic variants and sarcoidosis phenotypes in subgroups suggest that gene–environment-interactions may influence the clinical phenotype. In addition, we show that two different sets of genetic variants are permissive for the same phenotype of acute disease only in two geographic subcohorts pointing to interactions of genetic signatures with different local environmental factors. Our results represent an important step towards understanding the genetic architecture of sarcoidosis.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2023.1218106
    DOI: 10.3389/fmed.2023.1218106.s001
    DOI: 10.3389/fmed.2023.1218106.s002
    DOI: 10.3389/fmed.2023.1218106.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2775999-4
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  • 10
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    Evaluation of the role of pathology in the diagnosis and differential diagnosis of pulmonary and extrapulmonary sarcoidosis
    National Library of Serbia ; 2011
    In:  Srpski arhiv za celokupno lekarstvo Vol. 139, No. 7-8 ( 2011), p. 481-485
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 139, No. 7-8 ( 2011), p. 481-485
    Abstract: Uvod. Sarkoidoza je multisistemsko, granulomatozno oboljenje nepoznate etiologije. Sarkoidni granulomi nasta- ju kao imunski odgovor na odredjeni, ali jos nepoznati, agens u organizmu. Cilj rada. Cilj istrazivanja bio je da se ukaze na vaznu cinjenicu da se dijagnoza sarkoidoze postavlja jedino u klinicko-patoloskoj korelaciji, saradnjom klinicara i patologa. Metode rada. Od ukupno 751 bolesnika za kojeg se sumnjalo da boluje od sarkoidoze, analizirana su 663 (431 zena i 232 muskarca) kod kojih je tokom petogodisnjeg perioda postavljena dijagnoza sva tri stadijuma ovog oboljenja. Dijagnoza bolesti postavljena je na osnovu bioptickog materijala dobijenog tokom bronhoskopije, nalaza hirurske biopsije pluca, biopsije koze i biopsije jetre, kao i na osnovu splenektomije usled splenomegalije nepoznatog porekla. Rezultati. Odnos obolelih zena i muskaraca bio je 1,9:1. Bolesnici su imali izmedju 16 i 67 godina. Vecina bolesnika (78,4%) bila je stara do pedeset godina. Kod najveceg broja ispitanika ustanovljen je prvi stadijum plucne sarkoidoze (81,7%). Sarkoidoza je bila najcesci uzrok hilarne i medijastinalne limfadenopatije (72,2%). Zakljucak. Pacijente kod kojih klinicki, biohemijski i imunoloski testovi jasno pokazu da boluju od sarkoidoze potrebno je obavezno podvrgnuti biopsiji i patohistoloskoj dijagnostici uzorka uzetog tkiva pre zapocinjanja lecenja.
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH1108481S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2011
    detail.hit.zdb_id: 2577665-4
    detail.hit.zdb_id: 128567-1
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