In:
Frontiers in Pharmacology, Frontiers Media SA, Vol. 11 ( 2020-11-13)
Abstract:
Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects. Zanthoxylum bungeanum Maxim (ZBM) is a medicinal herb. The mature pericarp of ZBM is used for disease treatments and as spice for cooking. Here, we used the network pharmacology approach to investigate whether ZBM possesses anti-obesity effects and reveal the underlying mechanism of action. We first built up drug–ingredient–gene symbol–disease network and protein–protein interaction network of the ZBM-related obesity targets, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. The results highlight apoptosis as a promising signaling pathway that mediates the anti-obesity effects of ZBM. Molecular docking also reveals quercetin, a compound in ZBM has the highest degree of connections in the compound-target network and has direct bindings with the apoptotic markers. Furthermore, the apoptotic effects of ZBM are further validated in 3T3-L1 adipocytes and in the high-fat diet–induced obesity mouse model. These findings not only suggest ZBM can be developed as potential anti-obesity therapeutics but also demonstrate the application of network pharmacology for the discovery of herbal-based therapeutics for disease treatments.
Type of Medium:
Online Resource
ISSN:
1663-9812
DOI:
10.3389/fphar.2020.572387
DOI:
10.3389/fphar.2020.572387.s001
DOI:
10.3389/fphar.2020.572387.s002
DOI:
10.3389/fphar.2020.572387.s003
DOI:
10.3389/fphar.2020.572387.s004
DOI:
10.3389/fphar.2020.572387.s005
DOI:
10.3389/fphar.2020.572387.s006
DOI:
10.3389/fphar.2020.572387.s007
DOI:
10.3389/fphar.2020.572387.s008
DOI:
10.3389/fphar.2020.572387.s009
DOI:
10.3389/fphar.2020.572387.s010
DOI:
10.3389/fphar.2020.572387.s011
DOI:
10.3389/fphar.2020.572387.s012
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2020
detail.hit.zdb_id:
2587355-6
SSG:
15,3
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