In:
European Journal of Neurology, Wiley, Vol. 16, No. 2 ( 2009-02), p. 278-281
Abstract:
Background: Leukoencephalopathy with cerebral calcifications and cysts (LCC) is a recently described, very rare entity, clinically characterized by progressive neurological deficits such as cognitive decline, epileptic seizures, pyramidal, extrapyramidal and cerebellar symptoms/signs. With the exception of two patients with adult onset, in all previously described cases symptoms onset occurred between early infancy and adolescence. Results: We report a case of late onset LCC in a 59‐year‐old woman presenting with urinary and fecal incontinence and behavioural changes, then rapid progression with hemianopia, hemiparesis, ataxia and cognitive decline. Extensive work‐up was performed, including brain magnetic resonance imaging, magnetic resonance spectroscopy, cyst fluid analysis and brain biopsy, confirming the final diagnosis of LCC. Conclusion: Our case supports the existence of a late onset adult form of LCC.
Type of Medium:
Online Resource
ISSN:
1351-5101
,
1468-1331
DOI:
10.1111/ene.2009.16.issue-2
DOI:
10.1111/j.1468-1331.2008.02392.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2020241-6
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