In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 4 ( 2023-4-13), p. e0284404-
Abstract:
Signal inhibitory receptor on leukocytes-1 (SIRL-1) is an immune inhibitory receptor expressed on human myeloid cells. We previously showed that dendritic cell (DC)-driven Th17 cell differentiation of human naive CD4 + T cells requires presence of neutrophils, which is inhibited by SIRL-1 ligation. VSTM1-v2 is a soluble isoform of SIRL-1, which was previously proposed to function as a Th17 polarizing cytokine. Here, we investigated the effect of VSTM1-v2 on DC-driven Th17 cell development. Neutrophils induced DC-driven Th17 cell differentiation, which was not enhanced by VSTM1-v2. Similarly, we found no effect of VSTM1-v2 on cytokine-driven Th17 cell development. Thus, our results do not support a role for VSTM1-v2 in Th17 cell differentiation.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0284404
DOI:
10.1371/journal.pone.0284404.g001
DOI:
10.1371/journal.pone.0284404.s001
DOI:
10.1371/journal.pone.0284404.s002
DOI:
10.1371/journal.pone.0284404.s003
DOI:
10.1371/journal.pone.0284404.r001
DOI:
10.1371/journal.pone.0284404.r002
DOI:
10.1371/journal.pone.0284404.r003
DOI:
10.1371/journal.pone.0284404.r004
DOI:
10.1371/journal.pone.0284404.r005
DOI:
10.1371/journal.pone.0284404.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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