In:
Phlebology: The Journal of Venous Disease, SAGE Publications, Vol. 31, No. 5 ( 2016-06), p. 349-355
Abstract:
Arterial stiffness is associated with major adverse cardiovascular events. Chronic venous insufficiency (CVI) is severe form of chronic venous disease (CVD). The aim of this study is to investigate arterial stiffness by cardio-ankle vascular index (CAVI) in patients with CVI. Methods This observational and cross-sectional study involved 87 subjects with CVI and 86 healthy subjects. All subjects underwent ultrasonography examination. CAVI was measured by VaSera-1000 CAVI instrument. Results High density lipoprotein cholesterol (HDL) was significantly lower in patients with CVI than controls (46.83 ± 9.25 mg/dl vs 51.33 ± 11.13 mg/dl, p = 0.004). Body mass index (BMI) was significantly higher in CVI patients than controls (28.53 ± 4.10 kg/m 2 vs 26.37 ± 5.16 kg/m 2 , p = 0.003). Ankle brachial index (ABI) was significantly lower in patients with CVI compared to controls (1.08 ± 0.08 vs 1.14 ± 0.11, p 〈 0.001). CAVI was significantly higher in patients with CVI than controls (7.94 ± 1.37 vs 6.73 ± 1.16, p 〈 0.001). Mean arterial pressure (MAP) was significantly higher in patients with CVI than control group (105.41 ± 10.77 mmHg vs 99.70 ± 11.17 mmHg, p = 0.001). CAVI ( p 〈 0.001, Odds ratio (OR) = 2.033, 95% Confidence interval (CI) = 1.493–2.768), ABI ( p = 0.003, OR = 0.003, 95% CI = 0.001–0.137), female sex ( p 〈 0.001, OR = 3.949, 95% CI = 1.613–9.663), and HDL ( p 〈 0.001, OR = 0.923, 95% CI = 0.883–0.964) were the independent predictors of CVI. A CAVI value 〉 7.9 had a sensitivity 64.4% and a specificity of 94.7% for predicting the presence of CVI in ROC analysis (area under curve = 0.791, 95% CI = 0.723–0.849, p 〈 0.001). Conclusion CAVI is independently increased in CVI patients. Therefore CVI may be accepted a form of vascular sclerosis and vascular system should be evaluated in continuum not isolated.
Type of Medium:
Online Resource
ISSN:
0268-3555
,
1758-1125
DOI:
10.1177/0268355515591394
Language:
English
Publisher:
SAGE Publications
Publication Date:
2016
detail.hit.zdb_id:
1463018-7
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