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  • 1
    Online Resource
    Online Resource
    1 kHz single-frequency, injection-seeded Er:YAG laser with an optical feedback
    Shanghai Institute of Optics and Fine Mechanics ; 2019
    In:  Chinese Optics Letters Vol. 17, No. 3 ( 2019), p. 031402-
    Details
    In: Chinese Optics Letters, Shanghai Institute of Optics and Fine Mechanics, Vol. 17, No. 3 ( 2019), p. 031402-
    Type of Medium: Online Resource
    ISSN: 1671-7694
    Uniform Title: 1 kHz single-frequency, injection-seeded Er:YAG laser with an optical feedback
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.3788/COL/2019/17/3
    DOI: 10.3788/COL
    DOI: 10.3788/COL201917.031402
    Language: English , Chinese
    Publisher: Shanghai Institute of Optics and Fine Mechanics
    Publication Date: 2019
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  • 2
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    Identification of the ferroptosis-related long non-coding RNAs signature to improve the prognosis prediction and immunotherapy response in patients with NSCLC
    Springer Science and Business Media LLC ; 2021
    In:  BMC Medical Genomics Vol. 14, No. 1 ( 2021-12)
    Details
    In: BMC Medical Genomics, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2021-12)
    Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung carcinoma with an unfavorable prognosis. Ferroptosis is involved in the development of multiple cancers. Whereas, the prognostic value of ferroptosis-related lncRNAs in NSCLC remains uncertain. Methods Gene expression profiles and clinical information of NSCLC were retrieved from the TCGA database. Ferroptosis-related genes (FRGs) were explored in the FerrDb database and previous studies, ferroptosis-related lncRNAs (FRGs-lncRNAs) were identified by the correlation analysis and the LncTarD database. The differentially expressed FRGs-lncRNAs were screened and FRGs-lncRNAs associated with the prognosis were explored by univariate Cox regression analysis and Kaplan–Meier survival analysis. Then, an FRGs-lncRNAs signature was constructed and verified by the Lasso-penalized Cox analysis. Finally, the potential correlation between risk score, immune checkpoint genes, and chemotherapeutic sensitivity was further investigated. Results 129 lncRNAs with a potential regulatory relationship with 59 differentially expressed FRGs were found in NSCLC, of which 10 were related to the prognosis of NSCLC ( P   〈  0.05). 9 prognostic-related FRGs-lncRNAs were used to construct the prognostic model and stratify NSCLC patients into high- and low-risk groups. A worse outcome was found in patients with high risk ( P   〈  0.05). Moreover, a good predictive capacity of this signature in predicting NSCLC prognosis was confirmed. Additionally, 45 immune checkpoint genes and 4 chemotherapeutics drugs for NSCLC were identified to be correlated with the risk score. Conclusion A novel FRGs-lncRNAs signature was successfully constructed, which may contribute to improving the management strategies of NSCLC.
    Type of Medium: Online Resource
    ISSN: 1755-8794
    URL: Article
    DOI: 10.1186/s12920-021-01133-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2411865-5
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  • 3
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    Online Resource
    Cost-effectiveness of lung cancer screening combined with nurse-led smoking cessation intervention: A population-based microsimulation study
    Elsevier BV ; 2022
    In:  International Journal of Nursing Studies Vol. 134 ( 2022-10), p. 104319-
    Details
    In: International Journal of Nursing Studies, Elsevier BV, Vol. 134 ( 2022-10), p. 104319-
    Type of Medium: Online Resource
    ISSN: 0020-7489
    URL: Article
    DOI: 10.1016/j.ijnurstu.2022.104319
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2009451-6
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  • 4
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    Table_2.XLSX
    Frontiers Media SA ; 2021
    In:  Frontiers in Medicine Vol. 8 ( 2021-10-4)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-10-4)
    Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with unknown etiology and unfavorable prognosis. Ferroptosis is a form of regulated cell death with an iron-dependent way that is involved in the development of various diseases. Whereas the prognostic value of ferroptosis-related genes (FRGs) in IPF remains uncertain and needs to be further elucidated. Methods: The FerrDb database and the previous studies were screened to explore the FRGs. The data of patients with IPF were obtained from the GSE70866 dataset. Wilcoxon's test and univariate Cox regression analysis were applied to identify the FRGs that are differentially expressed between normal and patients with IPF and associated with prognosis. Next, a multigene signature was constructed by the least absolute shrinkage and selection operator (LASSO)-penalized Cox model in the training cohort and evaluated by using calibration and receiver operating characteristic (ROC) curves. Then, 30% of the dataset samples were randomly selected for internal validation. Finally, the potential function and pathways that might be affected by the risk score-related differently expressed genes (DEGs) were further explored. Results: A total of 183 FRGs were identified by the FerrDb database and the previous studies, and 19 of them were differentially expressed in bronchoalveolar lavage fluid (BALF) between IPF and healthy controls and associated with prognosis ( p & lt; 0.05). There were five FRGs (aconitase 1 [ACO1], neuroblastoma RAS viral (v-ras) oncogene homolog [NRAS] , Ectonucleotide pyrophosphatase/phosphodiesterase 2 [ENPP2], Mucin 1 [MUC1] , and ZFP36 ring finger protein [ZFP36]) identified as risk signatures and stratified patients with IPF into the two risk groups. The overall survival rate in patients with high risk was significantly lower than that in patients with low risk ( p & lt; 0.001). The calibration and ROC curve analysis confirmed the predictive capacity of this signature, and the results were further verified in the validation group. Risk score-related DEGs were found enriched in ECM-receptor interaction and focal adhesion pathways. Conclusion: The five FRGs in BALF can be used for prognostic prediction in IPF, which may contribute to improving the management strategies of IPF.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2021.693959
    DOI: 10.3389/fmed.2021.693959.s001
    DOI: 10.3389/fmed.2021.693959.s002
    DOI: 10.3389/fmed.2021.693959.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2775999-4
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  • 5
    Online Resource
    Online Resource
    Table_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-1-31)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-1-31)
    Abstract: The MDS1 and EVI1 complex locus (MECOM, also called PRDM3) and PR domain containing 16 (PRDM16) are two highly related zinc finger transcription factors associated with many malignancies. However, the mechanisms of MECOM and PRDM16 in prognosis and tumor immune infiltration in lung adenocarcinoma (LUAD) remain uncertain. Methods The Cancer Genome Atlas (TCGA), Oncomine, UALCAN, GEPIA, and TIMER databases were searched to determine the relationship between the expression of MECOM and PRDM16, clinicopathological features, immune infiltration, and prognosis in LUAD. Coexpressed genes of the two genes were investigated by CBioPortal, and the potential mechanism of MECOM- and PRDM16-related genes was elucidated by GO and KEGG analyses. STRING database was utilized to further construct the protein-protein interaction network of the coexpressed genes, and the hub genes were identified by Cytoscape. Finally, qRT-PCR was performed to identify the mRNA levels of the target genes in LUAD. Results mRNA levels of MECOM and PRDM16 were downregulated in LUAD ( p   & lt; 0.05), and the low expression of the two genes was associated with the age, gender, smoking duration, tissue subtype, poor stage, nodal metastasis status, TP53 mutation, and prognosis in LUAD ( p   & lt; 0.05). MECOM and PRDM16 were also found to be correlated with the expression of a variety of immune cell subsets and their markers. KEGG analysis showed that both of them were mainly enriched in the cell cycle, cellular senescence, DNA replication, and p53 signaling pathway. Importantly, the mRNA levels of the two genes were also found to be decreased in the clinical samples of LUAD by qRT-PCR. Conclusion MECOM and PRDM16 may serve as potential prognostic biomarkers which govern immune cell recruitment to LUAD.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2022.772686
    DOI: 10.3389/fonc.2022.772686.s001
    DOI: 10.3389/fonc.2022.772686.s002
    DOI: 10.3389/fonc.2022.772686.s003
    DOI: 10.3389/fonc.2022.772686.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 6
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    Online Resource
    Decentralized Threshold Signatures With Dynamically Private Accountability
    Institute of Electrical and Electronics Engineers (IEEE) ; 2024
    In:  IEEE Transactions on Information Forensics and Security Vol. 19 ( 2024), p. 2217-2230
    Details
    In: IEEE Transactions on Information Forensics and Security, Institute of Electrical and Electronics Engineers (IEEE), Vol. 19 ( 2024), p. 2217-2230
    Type of Medium: Online Resource
    ISSN: 1556-6013 , 1556-6021
    URL: Article
    DOI: 10.1109/TIFS.2023.3347968
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2024
    detail.hit.zdb_id: 2209730-2
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  • 7
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    Online Resource
    MECOM: a bioinformatics and experimentally identified marker for the diagnosis and prognosis of lung adenocarcinoma
    Informa UK Limited ; 2024
    In:  Biomarkers in Medicine Vol. 18, No. 2 ( 2024-01), p. 79-91
    Details
    In: Biomarkers in Medicine, Informa UK Limited, Vol. 18, No. 2 ( 2024-01), p. 79-91
    Abstract: Plain language summary Lung adenocarcinoma is a common type of lung cancer with a high incidence and death rate. However, clinical indicators that effectively identify lung adenocarcinoma patients are still lacking. The protein encoded by the MECOM gene is a DNA-binding protein regulating gene expression, which has been found to play a cancer-promoting role in many cancers, but we found that it may play a cancer-suppressing role in lung adenocarcinoma. This study aimed to confirm whether MECOM can be a predictor for lung adenocarcinoma. Our results showed that lung adenocarcinoma patients had lower serum MECOM levels than healthy people, and patients with lower MECOM levels had a shorter survival rate. That is, patients with lower serum MECOM levels may indicate a high risk of developing lung adenocarcinoma and death. Thus, the MECOM gene is expected to be a predictor associated with the risk of developing lung adenocarcinoma and death.
    Type of Medium: Online Resource
    ISSN: 1752-0363 , 1752-0371
    URL: Article
    DOI: 10.2217/bmm-2023-0600
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2024
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  • 8
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    Online Resource
    Metabolomics and molecular docking analysis of antibiotic exposure in Bifidobacterium adolescentis
    Oxford University Press (OUP) ; 2023
    In:  Letters in Applied Microbiology Vol. 76, No. 6 ( 2023-06-01)
    Details
    In: Letters in Applied Microbiology, Oxford University Press (OUP), Vol. 76, No. 6 ( 2023-06-01)
    Abstract: Bifidobacterium adolescentis is a probiotic. This research aimed to investigate the mechanism of antibiotics led to decrease in the number of B. adolescentis. The metabolomics approach was employed to explore the effects of amoxicillin on metabolism of B.adolescentis, while MTT assay and scanning electron microscopy were applied to analyse changes in viability and morphology of bacteria. Molecular docking was used to illuminate the mechanism by which amoxicillin acts on a complex molecular network. The results showed that increasing the concentration of amoxicillin led to a gradual decrease in the number of live bacteria. Untargeted metabolomics analysis identified 11 metabolites that change as a result of amoxicillin exposure. Many of these metabolites are involved in arginine and proline metabolism, glutathione metabolism, arginine biosynthesis, cysteine, and methionine metabolism, and tyrosine and phenylalanine metabolism. Molecular docking revealed that amoxicillin had a good binding effect on the proteins AGR1, ODC1, GPX1, GSH, MAT2A, and CBS. Overall, this research provides potential targets for screening probiotic regulatory factors and lays a theoretical foundation for the elucidation of its mechanisms.
    Type of Medium: Online Resource
    ISSN: 1472-765X
    URL: Article
    DOI: 10.1093/lambio/ovad061
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2020629-X
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  • 9
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    Online Resource
    Experimental Study of Water Infiltration in Unsaturated Horizontal Sand Columns under Various Air Confinement Conditions
    Hindawi Limited ; 2019
    In:  Geofluids Vol. 2019 ( 2019-12-18), p. 1-13
    Details
    In: Geofluids, Hindawi Limited, Vol. 2019 ( 2019-12-18), p. 1-13
    Abstract: The process of water infiltration into initially dry sand was studied in horizontal sand columns under various airtight conditions. To investigate the interrelations among water inflow behavior, air pressure, air confinement effect, and vent effectiveness in unsaturated porous media experiencing dynamic infiltration, a total of five dynamic infiltration experiments with fixed inlet water pressure were performed with different air vents open or closed along the column length. Visualizations of the infiltration process were accompanied by measurements of water saturation, air pressure, and accumulated water inflow. In a column system with an open end, the absence of air pressure buildup reveals that the vent at the column end can significantly reduce the internal air pressure effects during infiltration, and the air phase can be ignored for this case. However, in columns with a tight end, the coupled air and water flow processes can be divided into two completely different periods. Before the water front passed by the most distant open vent, the internal air pressure effects on retarding dynamic infiltration are negligible, similar to the open end case. After this period, the open vents can certainly influence the inflow behavior by functioning as air outlets while they cannot equilibrate pore air pressure with the atmospheric pressure. The remaining air ahead of the front will be gradually confined and compressed, and the significant increase in air pressure highlights the great role of air pressure buildup in reducing the water infiltration rate. The closer the last open vent was to the water inlet, the higher was the increase in air pressure and the greater was the delaying effect on water infiltration. This work may extend the experimental study of water infiltration into the unsaturated soils with different airtight conditions and provide experimental evidence on these coupled mechanisms among the water and air phases in soils.
    Type of Medium: Online Resource
    ISSN: 1468-8115 , 1468-8123
    URL: Article
    DOI: 10.1155/2019/4270358
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 10
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    Online Resource
    Enhanced photovoltaic performance via polarization in Bi/Co co‐doped KN‐based ferroelectric ceramics
    Wiley ; 2022
    In:  International Journal of Applied Ceramic Technology Vol. 19, No. 6 ( 2022-11), p. 3158-3169
    Details
    In: International Journal of Applied Ceramic Technology, Wiley, Vol. 19, No. 6 ( 2022-11), p. 3158-3169
    Abstract: A bandgap‐tunable KNbO 3 ferroelectric ceramic was prepared by introducing Bi/Co ion. The existence of mixed valence states of Co 2+ /Co 3+ in the system induced the bandgap reduction and its tunable behavior. KNbO 3 –BiCoO 3 solid solutions showed a typical orthogonal perovskite structure and maintained good ferroelectricity ( P s  = 15.13 µC/cm 2 ) and high‐field polarization ability. The devices based on the .98KNbO 3 –.02BiCoO 3 sample exhibited an improved short‐circuit photocurrent density ( J sc ) of 19.2 nA/cm 2 under simulated solar radiation, and this was further enhanced to 79.8 nA/cm 2 after a 60‐kV/cm polarizing. The structural analysis of the samples after polarization reveals the effect of ferroelectric polarization on photovoltaic performance. This work provides new insights into the effects of ferroelectric polarization on photovoltaic performance.
    Type of Medium: Online Resource
    ISSN: 1546-542X , 1744-7402
    URL: Issue
    URL: Article
    DOI: 10.1111/ijac.v19.6
    DOI: 10.1111/ijac.14177
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2167226-X
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