In:
Journal of Oral Pathology & Medicine, Wiley, Vol. 44, No. 4 ( 2015-04), p. 244-251
Abstract:
Mammary analog secretory carcinoma ( MASC ) of the salivary gland has been recently described according to morphological, immunohistochemical, and molecular ( ETV 6‐ NTRK 3 translocation) similarities with the mammary secretory carcinoma. The most important differential diagnostic considerations of MASC are low‐grade adenocarcinoma not otherwise specified ( NOS ), cystadenocarcinoma, and acinic cell carcinoma (Aci CC ). These tumors may share an overlapping morphology with MASC , and additional immunohistochemical studies are required to reinforce the diagnosis. Mammaglobin, GCDFP ‐15, and p63 staining have been reported in MASC . Our study was designed to check the specificity of these antibodies in MASC compared to other frequent tumors of salivary glands. Methods A series of 62 salivary gland tumors [10 MASC s, 5 adenocarcinomas NOS and 2 cystadenocarcinomas with MASC features and without ETV 6 rearrangement, one low‐grade cribriform cystadenocarcinoma ( LGCCC ), 9 AciCCs, 10 MEC s, 10 adenoid cystic carcinomas (Ade CC s), 5 polymorphous low‐grade adenocarcinomas ( PLGA s), and 10 pleomorphic adenomas ( PA s)] was analyzed by immunohistochemistry with mammaglobin, GCDFP ‐15, and p63 antibodies. Results Positivity for mammaglobin was observed in all MASC s, cystadenocarcinomas, LGCCC , and PLGA s, in some adenocarcinomas NOS , PA s, and MEC s, rarely in Aci CC s and never in Ade CC s. Positivity for GCDFP ‐15 was observed in most of the tumor types except in Ade CC s. Interestingly, cytoplasmic positivity for p63 was observed in most of MASC s and PLGA s while rarely in adenocarcinomas NOS and PA s, and never in the other tumor types. Conclusion Our study revealed the usefulness of mammaglobin and p63 cytoplasmic staining to define which tumors are worth to be screened for ETV6 rearrangement.
Type of Medium:
Online Resource
ISSN:
0904-2512
,
1600-0714
DOI:
10.1111/jop.2015.44.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2026385-5
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