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  • 1
    Online Resource
    Online Resource
    A stepwise strategy integrating dynamic stress CT myocardial perfusion and deep learning–based FFRCT in the work-up of stable coronary artery disease
    Springer Science and Business Media LLC ; 2024
    In:  European Radiology
    Details
    In: European Radiology, Springer Science and Business Media LLC
    Abstract: To validate a novel stepwise strategy in which computed tomography–derived fractional flow reserve (FFR CT ) is restricted to intermediate stenosis on coronary computed tomography angiography (CCTA) and computed tomography myocardial perfusion imaging (CT-MPI) was reserved for vessels with gray zone FFR CT values. Materials and methods This retrospective study included 87 consecutive patients (age, 58 ± 10 years; 70% male) who underwent CCTA, dynamic CT-MPI, interventional coronary angiography (ICA), and fractional flow reserve (FFR) for suspected or known coronary artery disease. FFR CT was computed using a deep learning–based platform. Three stepwise strategies (CCTA + FFR CT + CT-MPI, CCTA + FFR CT , CCTA + CT-MPI) were constructed and their diagnostic performance was evaluated using ICA/FFR as the reference standard. The proportions of vessels requiring further ICA/FFR measurement based on different strategies were noted. Furthermore, the net reclassification index (NRI) was calculated to ascertain the superior model. Results The CCTA + FFR CT + CT-MPI strategy yielded the lowest proportion of vessels requiring additional ICA/FFR measurement when compared to the CCTA + FFR CT and CCTA + CT-MPI strategies (12%, 22%, and 24%). The CCTA + FFR CT + CT-MPI strategy exhibited the highest accuracy for ruling-out (91%, 84%, and 85%) and ruling-in (90%, 85%, and 85%) functionally significant lesions. All strategies exhibited comparable sensitivity for ruling-out functionally significant lesions and specificity for ruling-in functionally significant lesions ( p 〉 0.05). The NRI indicated that the CCTA + FFR CT + CT-MPI strategy outperformed the CCTA + FFR CT strategy (NRI = 0.238, p 〈 0.001) and the CCTA + CT-MPI strategy (NRI = 0.233%, p 〈 0.001). Conclusions The CCTA + FFR CT + CT-MPI stepwise strategy was superior to the CCTA + FFR CT strategy and CCTA+ CT-MPI strategy by minimizing unnecessary invasive diagnostic catheterization without compromising the agreement rate with ICA/FFR. Clinical relevance statement Our novel stepwise strategy facilitates greater confidence and accuracy when clinicians need to decide on interventional coronary angiography referral or deferral, reducing the burden of invasive investigations on patients. Key Points • A stepwise CCTA + FFR CT + CT-MPI strategy holds promise as a viable method to reduce the need for invasive diagnostic catheterization, while maintaining a high level of agreement with ICA/FFR. • The CCTA + FFR CT + CT-MPI strategy performed better than the CCTA + FFR CT and CCTA + CT-MPI strategies. • A stepwise CCTA + FFR CT + CT-MPI strategy allows to minimize unnecessary invasive diagnostic catheterization and helps clinicians to referral or deferral for ICA/FFR with more confidence.
    Type of Medium: Online Resource
    ISSN: 1432-1084
    URL: Article
    DOI: 10.1007/s00330-023-10562-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 1472718-3
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  • 2
    Online Resource
    Online Resource
    Novel Flexible Material-Based Unobtrusive and Wearable Body Sensor Networks for Vital Sign Monitoring
    Institute of Electrical and Electronics Engineers (IEEE) ; 2019
    In:  IEEE Sensors Journal Vol. 19, No. 19 ( 2019-10-1), p. 8502-8513
    Details
    In: IEEE Sensors Journal, Institute of Electrical and Electronics Engineers (IEEE), Vol. 19, No. 19 ( 2019-10-1), p. 8502-8513
    Type of Medium: Online Resource
    ISSN: 1530-437X , 1558-1748 , 2379-9153
    URL: Journal
    URL: Article
    DOI: 10.1109/JSEN.7361
    DOI: 10.1109/JSEN.2018.2887107
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2019
    detail.hit.zdb_id: 2052059-1
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  • 3
    Online Resource
    Online Resource
    Spectrum projection with a bandgap-gradient perovskite cell for colour perception
    Springer Science and Business Media LLC ; 2020
    In:  Light: Science & Applications Vol. 9, No. 1 ( 2020-09-15)
    Details
    In: Light: Science & Applications, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2020-09-15)
    Abstract: Optoelectronic devices for light or spectral signal detection are desired for use in a wide range of applications, including sensing, imaging, optical communications, and in situ characterization. However, existing photodetectors indicate only light intensities, whereas multiphotosensor spectrometers require at least a chip-level assembly and can generate redundant signals for applications that do not need detailed spectral information. Inspired by human visual and psychological light perceptions, the compression of spectral information into representative intensities and colours may simplify spectrum processing at the device level. Here, we propose a concept of spectrum projection using a bandgap-gradient semiconductor cell for intensity and colour perception. Bandgap-gradient perovskites, prepared by a halide-exchanging method via dipping in a solution, are developed as the photoactive layer of the cell. The fabricated cell produces two output signals: one shows linear responses to both photon energy and flux, while the other depends on only photon flux. Thus, by combining the two signals, the single device can project the monochromatic and broadband spectra into the total photon fluxes and average photon energies (i.e., intensities and hues), which are in good agreement with those obtained from a commercial photodetector and spectrometer. Under changing illumination in real time, the prepared device can instantaneously provide intensity and hue results. In addition, the flexibility and chemical/bio-sensing of the device via colour comparison are demonstrated. Therefore, this work shows a human visual-like method of spectrum projection and colour perception based on a single device, providing a paradigm for high-efficiency spectrum-processing applications.
    Type of Medium: Online Resource
    ISSN: 2047-7538
    URL: Article
    DOI: 10.1038/s41377-020-00400-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2662628-7
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  • 4
    Online Resource
    Online Resource
    Data_Sheet_1.PDF
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-2-3)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-2-3)
    Abstract: Dynamic CT myocardial perfusion imaging (CT-MPI) allows absolute quantification of myocardial blood flow (MBF). Although appealing, CT-MPI has not yet been widely applied in clinical practice, partly due to our relatively limited knowledge of CT-MPI. Knowledge of distribution and variability of MBF in healthy subjects helps in recognition of physiological and pathological states of coronary artery disease (CAD). Objectives To describe the distribution and normal range of hyperemic MBF in healthy subjects obtained by dynamic CT-MPI and validate whether it can accurately identify functional myocardial ischemia when the cut-off value of hyperemia MBF is set to the lower limit of the normal range. Materials and Methods Fifty-one healthy volunteers (age, 38 ± 12 years; 15 men) were prospectively recruited. Eighty patients (age, 58 ± 10 years; 55 men) with suspected or known CAD who underwent interventional coronary angiography (ICA) examinations were retrospectively recruited. Comprehensive CCTA + dynamic CT-MPI protocol was performed by the third – generation dual-source CT scanner. Invasive fractional flow reserve (FFR) measurements were performed in vessels with 30–90% diameter reduction. ICA/FFR was used as the reference standard for diagnosing functional ischemia. The normal range for the hyperemic MBF were defined as the mean ± 1.96 SD. The cut-off value of hyperemic MBF was set to the lower limit of the normal range. Results The global hyperemic MBF were 164 ± 24 ml/100 ml/min and 123 ± 26 ml/100 ml/min for healthy participants and patients. The normal range of the hyperemic MBF was 116–211 ml/100 ml/min. Of vessels with an ICA/FFR result ( n = 198), 67 (34%) were functionally significant. In the per-vessel analysis, an MBF cutoff value of & lt;116 ml/100 ml/min can identify myocardial ischemia with a diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of 85.9% (170/198), 91.0% (61/67), 83.2 % (109/131), 73.5% (61/83), and 94.8% (109/115). CT-MPI showed good consistency with ICA/FFR in diagnosing functional ischemia, with a Cohen's kappa statistic of 0.7016 (95%CI, 0.6009 – 0.8023). Conclusion Recognizing hyperemic MBF in healthy subjects helps better understand myocardial ischemia in CAD patients.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.817911
    DOI: 10.3389/fcvm.2022.817911.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 5
    Online Resource
    Online Resource
    Single Whispering Gallery Mode in Mesh‐Structured Tubular Microcavity with Tunable Axial Confinement
    Wiley ; 2021
    In:  Advanced Photonics Research Vol. 2, No. 5 ( 2021-05)
    Details
    In: Advanced Photonics Research, Wiley, Vol. 2, No. 5 ( 2021-05)
    Abstract: Single‐mode lasing with high‐beam quality and wide‐range spectral purity is of fundamental importance in scientific and technical applications. Lacking a mode selection strategy, achieving single whispering gallery mode (WGM)‐type lasing remains a challenge. Herein, a wide‐range tunable single‐WGM resonance in a mesh‐structured tubular microcavity is realized by combining WGM resonance with distributed feedback effect, and the single mode can be systematically and precisely tuned by tailoring the geometry parameters of the hole array. In addition, switching between single mode and multimode WGM can be achieved at different axial directions of one individual tubular microcavity. The structure provides additional degrees of freedom to manipulate the resonant spectra characteristics and the spatial distribution of resonant modes, thus having a promising future in micro‐/nano‐optical devices.
    Type of Medium: Online Resource
    ISSN: 2699-9293 , 2699-9293
    URL: Issue
    URL: Article
    DOI: 10.1002/adpr.v2.5
    DOI: 10.1002/adpr.202000163
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 3009932-8
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  • 6
    Online Resource
    Online Resource
    Versatile Approach for Integrative and Functionalized Tubes by Strain Engineering of Nanomembranes on Polymers
    Wiley ; 2008
    In:  Advanced Materials Vol. 20, No. 21 ( 2008-11-03), p. 4085-4090
    Details
    In: Advanced Materials, Wiley, Vol. 20, No. 21 ( 2008-11-03), p. 4085-4090
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v20:21
    DOI: 10.1002/adma.200801589
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 1474949-X
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  • 7
    Online Resource
    Online Resource
    Morphological Differentiation of Neurons on Microtopographic Substrates Fabricated by Rolled‐Up Nanotechnology
    Wiley ; 2010
    In:  Advanced Engineering Materials Vol. 12, No. 9 ( 2010-09)
    Details
    In: Advanced Engineering Materials, Wiley, Vol. 12, No. 9 ( 2010-09)
    Abstract: Arrays of transparent rolled‐up microtubes can easily be mass‐produced using a combination of conventional photolithography, electron beam depositioning, and chemical etching techniques. Here, we culture primary mouse motor neurons and immortalised CAD cells, a cell line derived from the central nervous system, on various microtube substrates to investigate the influence of topographical surface features on the growth and differentiation behaviour of these cells. Our results indicate that the microtube chips not only support growth of both cell types but also provide a well‐defined, geometrically confined 3D cell culture scaffold. Strikingly, our micropatterns act as a platform for axon guidance with protruding cell extensions aligning in the direction of the microtubes and forming complex square‐shaped grid‐like neurite networks. Our experiments open up a cost‐efficient and bio‐compatible way of analysing single cell behaviour in the context of advanced micro‐/nanostructures with various biological applications ranging from neurite protection studies to cell sensor development.
    Type of Medium: Online Resource
    ISSN: 1438-1656 , 1527-2648
    URL: Issue
    URL: Article
    DOI: 10.1002/adem.v12:9
    DOI: 10.1002/adem.201080023
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2016980-2
    detail.hit.zdb_id: 1496512-4
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  • 8
    Online Resource
    Online Resource
    Atomic Layer Deposition Inducing Integration of Co, N Codoped Carbon Sphere on 3D Foam with Hierarchically Porous Structures for Flexible Hydrogen Producing Device
    Wiley ; 2019
    In:  Advanced Functional Materials Vol. 29, No. 48 ( 2019-11)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 29, No. 48 ( 2019-11)
    Abstract: Integration of metal–organic frameworks on deformation tolerant substrates exhibits a promising prospect in flexible electrode applications. A straightforward synthesis utilizing atomic layer deposition pretreating to induce the growth of a zeolitic imidazolate framework‐67 (ZIF‐67) layer on carbon foam (CF), which maintains high ZIF‐67 loading with a hierarchically porous structure and large surface area of 453 m 2 g −1 is presented. With a subsequent pyrolysis process, three‐dimensional composite structures are obtained with Co, N codoped carbon spheres attached firmly on the CF framework, and CF bridges the individual carbon spheres to construct a conductive pathway. The composites are used as a flexible electrode for hydrogen production both in acid and alkaline electrolytes. The advances in the composite structure, such as the hierarchically porous structure, large surface area, and high loading of active material, lead to excellent electrochemical performance in terms of low overpotential of 142 mV and low Tafel slope of 73 mV dec −1 in 0.5 m H 2 SO 4 . Most importantly, the composite structure with outstanding flexible property shows good catalytic performance under remarkable deformation, and after 100 repeated compression–recovery cycles, the performance degrades slightly. This work provides a new design of flexible electrode, which is promising for the hydrogen production industry.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v29.48
    DOI: 10.1002/adfm.201906365
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 9
    Online Resource
    Online Resource
    Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications
    Wiley ; 2021
    In:  Advanced Materials Vol. 33, No. 22 ( 2021-06)
    Details
    In: Advanced Materials, Wiley, Vol. 33, No. 22 ( 2021-06)
    Abstract: Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v33.22
    DOI: 10.1002/adma.202007465
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1474949-X
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  • 10
    Online Resource
    Online Resource
    Self‐rolled‐up Ultrathin Single‐Crystalline Silicon Nanomembranes for On‐Chip Tubular Polarization Photodetectors
    Wiley ; 2023
    In:  Advanced Materials
    Details
    In: Advanced Materials, Wiley
    Abstract: Freestanding single‐crystalline nanomembranes and their assembly have broad application potential in photodetectors for integrated chips. However, the release and self‐assembly process of single‐crystalline semiconductor nanomembranes still remains great challenges in on‐chip processing and functional integration, and photodetectors based on nanomembrane always suffer from limited absorption of nanoscale thickness. Here, we employ a non‐destructive releasing and rolling process to prepare tubular photodetectors based on freestanding single‐crystalline Si nanomembranes. Spontaneous release and self‐assembly are achieved by residual strain introduced by lattice mismatch at the epitaxial interface of Si and Ge, and the intrinsic stress and strain distributions in self‐rolled‐up Si nanomembranes are analyzed experimentally and computationally. The advantages of light trapping and wide‐angle optical coupling are realized by tubular geometry. Our Si microtube device achieves reliable Ohmic contact and exhibits a photoresponsivity of over 330 mA/W, a response time of 370 μs, and a light incident detection angle range of over 120°. Furthermore, the microtubular structure shows a distinct polarization angle‐dependent light absorption, with a dichroic ratio of 1.24 achieved at 940 nm. The proposed Si‐based microtubes provide new possibilities for the construction of multifunctional chips for integrated circuit ecosystems in More than Moore era. This article is protected by copyright. All rights reserved
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Article
    DOI: 10.1002/adma.202306715
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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