In:
Journal of Periodontology, Wiley, Vol. 90, No. 3 ( 2019-03), p. 295-305
Abstract:
Periodontitis not only causes injury to the periodontium, but also damages other tissues such as: articulate, renal, cardiac, and hepatic. The objective of this study was to investigate periodontitis induced alterations in liver function and structure using an experimental model. Methods Twenty female rats ( Rattus norvegicus ) were allocated into two groups: control and periodontitis. Gingival bleeding index and oxidative stress parameters and specific circulating biomarkers were measured. Immunohistochemistry was carried out using alkaline phosphatase (AlkP) staining of the liver. Hepatic tissues, cytokines, and lipid contents were measured. Histopathologic evaluation of the liver was carried out using light and electron microscopy. Results Liver histopathologic and immunohistochemistry assessment showed increase in steatosis score, and presence of binucleate hepatocytes and positive cells for AlkP in periodontitis versus control group. Ultrastructural evaluation showed significant increase in size and number of lipid droplets (LD), distance between the cisterns of rough endoplasmic reticulum (RER), mitochondria size, foamy cytoplasm, and glycogen accumulation in the liver of the periodontitis group compared with the control group. In addition, plasma levels of AlkP, high‐density lipoprotein (HDL), triglycerides, and total cholesterol were also changed. Conclusion Experimental periodontitis caused immunohistochemistry, histopathologic, ultrastructural, oxidative, and biochemical changes in the liver of rats.
Type of Medium:
Online Resource
ISSN:
0022-3492
,
1943-3670
DOI:
10.1002/jper.2019.90.issue-3
DOI:
10.1002/JPER.18-0226
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2040047-0
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