In:
Angewandte Chemie, Wiley, Vol. 130, No. 22 ( 2018-05-28), p. 6768-6771
Abstract:
A simple and rapid method for 18 F radiolabelling of [GaF 3 (BnMe 2 ‐tacn)] by 18 F/ 19 F isotopic exchange is described. The use of MeCN/H 2 O or EtOH/H 2 O (75:25) and aqueous [ 18 F]F − (up to 200 MBq) with heating (80 °C, 10 min) gave 66±4 % 18 F incorporation at a concentration of 268 n m , and 37±5 % 18 F incorporation at even lower concentration (27 n m ), without the need for a Lewis acid promoter. A solid‐phase extraction method was established to give [Ga 18 F 19 F 2 (BnMe 2 ‐tacn)] in 99 % radiochemical purity in an EtOH/H 2 O mixture.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.22
DOI:
10.1002/ange.201802446
Language:
English
Publisher:
Wiley
Publication Date:
2018
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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