In:
Blood, American Society of Hematology, Vol. 26, No. 5 ( 1965-11-01), p. 597-609
Abstract:
The establishment of a hematopoietic graft of stem cells from a donor with chronic myelogenous leukemia in a patient with acute leukemia took place in the face of ABO red cell group incompatibility. The donor was group A and the recipient who was group O gradually increased his red cell mass to become 80 per cent group A. There was both active and passive immunity to A present at the time of induction of the graft. The graft flourished despite persistent anti-A agglutinins and an immune response in the B agglutinin and hemolysin system. Failure of the graft coincided with a fall in antibody levels and was followed by a second immune response which included marked elevation of 7S gamma globulin levels. Red cell incompatibility was not a barrier to this graft and failure of the graft was probably due to other immune mechanisms.
Type of Medium:
Online Resource
ISSN:
0006-4971
,
1528-0020
DOI:
10.1182/blood.V26.5.597.597
Language:
English
Publisher:
American Society of Hematology
Publication Date:
1965
detail.hit.zdb_id:
1468538-3
detail.hit.zdb_id:
80069-7
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