In:
Obesity, Wiley, Vol. 25, No. 5 ( 2017-05), p. 935-944
Abstract:
This study investigated genetic determinants of adiponectin during pregnancy to reveal novel biology of adipocyte regulation. Methods A genome‐wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured at ∼28 weeks of gestation. Variants reaching P 〈 5×10 −5 for de novo genotyping in two replication cohorts (Genetics of Glycemic regulation in Gestation and Growth N = 522; ECOGENE‐21 N = 174) were selected. Results In the combined meta‐analysis, the maternal T allele of rs900400 located on chr3q25 (near LEKR1 / CCNL1 ) was associated with lower maternal adiponectin (β ± standard error [SE] = −0.18 ± 0.03 standard deviation [SD] of adiponectin per risk allele; P = 1.5 10 −8 ; N = 2,004; multivariable adjusted models). In contrast, rs900400 showed only nominal association with adiponectin in a large sample of nonpregnant women (β ± SE = −0.012 ± 0.006; P = 0.05; N = 16,678 women from the ADIPOgen consortium). The offspring rs900400 T risk allele was associated with greater neonatal skinfold thickness (β ±SE = 0.19 ± 0.04 SD per risk allele; P = 4.1×10 −8 ; N = 1,489) and higher cord blood leptin (β ± SE = 0.28 ± 0.05 log‐leptin per risk allele; P = 8.2 10 −9 ; N = 502), but not with cord blood adiponectin ( P = 0.23; N = 495). The T allele of rs900400 was associated with higher expression of TIPARP in adipocytes. Conclusions These investigations of adipokines during pregnancy and early life suggest that rs900400 has a role in adipocyte function.
Type of Medium:
Online Resource
ISSN:
1930-7381
,
1930-739X
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2027211-X
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