In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 74, No. Suppl_1 ( 2019-09)
Abstract:
Exercise is a primary lifestyle intervention to control cardiovascular diseases such as hypertension. Exercise capacity and its health benefits are inheritable. However, the mechanisms by which exercise capacity differences influence overall health state remain unclear. We first hypothesized that low and high intrinsic exercise capacity lead to distinct heart weight and vascular function. Animal model (male, 20-24-weeks old, n = 6): heterogeneous stock selectively bred for over 20 years to produce low-capacity running rats (LCR) and high-capacity running rats (HCR), and an intrinsic control, high response trainer rats (HRT, control). Statistics: t-test: *p 〈 0.05. Left ventricular (LV) weight was normalized by tibia length. We observed that HCR presented with LV hypertrophy compared to LCR and control (Control: 0.0155 ± 0.0006 vs. HCR: 0.0192 ± 0.0007* vs. LCR: 0.0164 ± 0.0004). Performing wire myography with 3 rd -order mesenteric resistance arteries (MRA), we observed that LCR MRA had an impaired maximum relaxation response (E max ) to acetylcholine (ACh) compared to HCR and control (Control: 94.99 ± 1.79 vs. HCR: 93.49 ± 12.17 vs. LCR: 72.95 ± 12.40*). Next, we questioned if these differences were the result of mitochondria. We used two reciprocal conplastic strains created by utilizing maternal mitochondrial inheritance (male, 30-36-weeks old, n = 4): LCR nuclear genome with HCR mitochondria (LCR.HCR mt ) and the reciprocal HCR.LCR mt . We observed that LCR.HCR mt presented with LV hypertrophy compared to LCR (0.0195 ± 0.0002* vs 0.0164 ± 0.0004) while HCR.LCR mt abolished HCR LV hypertrophy (0.0151 ± 0.0002* vs. 0.0192 ± 0.0007). Interestingly, in a separate group of animals (n = 4 - 5), LCR had higher mean arterial pressure (MAP) compared to HCR, and LCR.HCR mt had reduced MAP compared to LCR (LCR: 119 ± 2 vs. LCR.HCR mt : 111 ± 1*). No changes were observed in HCR.LCR mt compared to HCR. Further, LCR.HCR mt MRA presented with improved E max to ACh compared to LCR MRA (LCR: 72 ± 12 vs. LCR.HCR mt : 93 ± 2*) while no changes were observed in HCR.LCR mt MRA compared to HCR MRA. Overall, we conclude that intrinsic exercise capacity is directly proportional to cardiovascular effects. Similar to the nuclear genome, mitochondria are the key to this hereditary predisposition.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/hyp.74.suppl_1.122
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
detail.hit.zdb_id:
2094210-2
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