In:
Clinical Endocrinology, Wiley, Vol. 79, No. 2 ( 2013-08), p. 259-266
Abstract:
To investigate the frequencies of three paraoxonase ( PON )1 polymorphisms in Greek polycystic ovary syndrome ( PCOS ) and non‐ PCOS women, and their genotypes association with hyperandrogenaemia and insulin resistance. Design Case–control genetic association study. Setting University Hospital Endocrine Unit. Patients A total of 142 PCOS cases (NIH criteria) and 112 controls. Main Outcome Measure Genotyping of the c.–108C 〉 T ( PON 1‐108), the c.163T 〉 A ( PON 1‐55) and the c.575A 〉 G ( PON 1‐192) polymorphisms and measurement of baseline androgen and insulin resistance profile. Results The PON 1‐108 TT and PON 1‐192 RR genotypes were more frequently encountered in the PCOS than in the control group. The PON 1‐192 R allele frequency was greater in the PCOS than in the control group. Comparing the PCOS and the control groups, statistical significances favoured a recessive and a dominant genetic model, respectively, for the single PON 1‐108 T and PON 1‐192 R alleles. Free Androgen Index ( FAI ) levels were higher in patients with PON 1‐108 TT, whereas Testosterone, FAI and Dehydroepiandrosterone sulphate ( DHEAS ) levels were higher in patients with PON 1‐192 RR than patients with the wild or the heterozygous genotype. Conclusions The decreased PON 1 activity‐associated PON 1‐108 TT and the PON 1‐192 RR genotypes are more frequently found in Greek PCOS women and are associated with hyperandrogenaemia. Hyperandrogenaemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenaemia in the control group. Through identification of the involved polymorphisms, women with PCOS could potentially have a better therapeutic screening.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2013.79.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2004597-9
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