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  • 1
    Online Resource
    Online Resource
    The impact of iron store on red blood cell transfusion: a multicentre prospective cohort study in cardiac surgery
    Springer Science and Business Media LLC ; 2022
    In:  BMC Anesthesiology Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Anesthesiology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: Anaemia is common prior to cardiac surgery and contributes to perioperative morbidity. Iron deficiency is the main cause of anaemia but its impact remains controversial in the surgical setting. We aimed to estimate the impact of iron deficiency on in-hospital perioperative red blood cell transfusion for patients undergoing elective and urgent cardiac surgery. Secondary objectives were to identify risk factors associated with in-hospital red blood cell transfusion. Methods We conducted a prospective multicentre observational study in three university hospitals performing cardiac surgery. We determined iron status prior to surgery and collected all transfusion data to compare iron-deficient and iron-replete patients during hospital stay. We performed a multivariable logistic regression to compare transfusion among groups. Results Five hundred and two patients were included. A trend of low haemoglobin levels associated with iron deficiency persisted until discharge. Red blood cell transfusion was significantly higher in the group of iron deficient patients during surgery (22% vs 13%, p  = 0.017), however the incidence during the whole hospital stay was 31% in the iron-deficient group, not significantly different with the non-deficient group (26%, p  = 0.28). Iron deficiency was not independently associated with in-hospital red blood cell transfusion (adjusted OR = 0.85 [0.53–1.36], p  = 0.49). Conclusions In-hospital red blood cell transfusion was not significantly higher in iron-deficient patients and iron deficiency was not associated with in-hospital red blood cell transfusion in patients undergoing elective and urgent cardiac surgery. Iron deficiency was the main cause of anaemia and anaemia was a strong driver of red blood cell transfusion. Further studies should identify sub-population of iron-deficient patients which may benefit from preoperative iron deficiency management and explore the long-term impact of lower haemoglobin levels at discharge in the iron deficient population.
    Type of Medium: Online Resource
    ISSN: 1471-2253
    URL: Article
    DOI: 10.1186/s12871-022-01616-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2091252-3
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  • 2
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    Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study
    Springer Science and Business Media LLC ; 2021
    In:  Annals of Intensive Care Vol. 11, No. 1 ( 2021-12)
    Details
    In: Annals of Intensive Care, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-12)
    Abstract: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding hospital acquired bloodstream infections (BSI) are scarce. We aimed to investigate risk factors and outcome of BSI in critically ill coronavirus infectious disease-19 (COVID-19) patients. Patients and methods We performed an ancillary analysis of a multicenter prospective international cohort study (COVID-ICU study) that included 4010 COVID-19 ICU patients. For the present analysis, only those with data regarding primary outcome (death within 90 days from admission) or BSI status were included. Risk factors for BSI were analyzed using Fine and Gray competing risk model. Then, for outcome comparison, 537 BSI-patients were matched with 537 controls using propensity score matching. Results Among 4010 included patients, 780 (19.5%) acquired a total of 1066 BSI (10.3 BSI per 1000 patients days at risk) of whom 92% were acquired in the ICU. Higher SAPS II, male gender, longer time from hospital to ICU admission and antiviral drug before admission were independently associated with an increased risk of BSI, and interestingly, this risk decreased over time. BSI was independently associated with a shorter time to death in the overall population (adjusted hazard ratio (aHR) 1.28, 95% CI 1.05–1.56) and, in the propensity score matched data set, patients with BSI had a higher mortality rate (39% vs 33% p  = 0.036). BSI accounted for 3.6% of the death of the overall population. Conclusion COVID-19 ICU patients have a high risk of BSI, especially early after ICU admission, risk that increases with severity but not with corticosteroids use. BSI is associated with an increased mortality rate.
    Type of Medium: Online Resource
    ISSN: 2110-5820
    URL: Article
    DOI: 10.1186/s13613-021-00971-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2617094-2
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  • 3
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    The GLAM Airborne Campaign across the Mediterranean Basin
    American Meteorological Society ; 2018
    In:  Bulletin of the American Meteorological Society Vol. 99, No. 2 ( 2018-02-01), p. 361-380
    Details
    In: Bulletin of the American Meteorological Society, American Meteorological Society, Vol. 99, No. 2 ( 2018-02-01), p. 361-380
    Abstract: The Gradient in Longitude of Atmospheric Constituents above the Mediterranean Basin (GLAM) airborne campaign was set up to investigate the summertime variability of gaseous pollutants, greenhouse gases, and aerosols between the western (∼3°E) and eastern (∼35°E) sections of the Mediterranean basin as well as how this connects with the impact of the Asian monsoon anticyclone on the eastern Mediterranean in the mid- to upper troposphere (∼5–10 km). GLAM falls within the framework of the Chemistry–Aerosol Mediterranean Experiment (ChArMEx) program. GLAM used the French Falcon-20 research aircraft to measure aerosols, humidity, and chemical compounds: ozone, carbon monoxide, methane, and carbon dioxide. GLAM took place between 6 and 10 August 2014, following a route from Toulouse (France) to Larnaca (Cyprus) and back again via Minorca (Spain), Lampedusa (Italy), and Heraklion (Crete, Greece). The aircraft flew at an altitude of 5 km on its outbound journey and 10 km on the return leg. GLAM also collected vertical profiles around the landing sites listed above. A combination of model outputs, chemical mapping analyses, and spaceborne and surface station measurements gathered prior to and during the campaign were used to interpret the in situ airborne measurements. The main outcome of this study is the impact of intercontinental transport on the longitudinal variability of pollutants, greenhouse gases, and aerosols at an altitude of 10 km. The eastern Mediterranean is affected by air masses from the Arabian Sea surface, and the western Mediterranean is impacted by air masses from North America (biomass burning) and West Africa (desert dust).
    Type of Medium: Online Resource
    ISSN: 0003-0007 , 1520-0477
    URL: Article
    DOI: 10.1175/BAMS-D-16-0226.1
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2018
    detail.hit.zdb_id: 2029396-3
    detail.hit.zdb_id: 419957-1
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  • 4
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    Correction to: Characteristics and prognosis of bloodstream infection in patients with COVID‑19 admitted in the ICU: an ancillary study of the COVID‑ICU study
    Springer Science and Business Media LLC ; 2022
    In:  Annals of Intensive Care Vol. 12, No. 1 ( 2022-12)
    Details
    In: Annals of Intensive Care, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-12)
    Type of Medium: Online Resource
    ISSN: 2110-5820
    URL: Article
    DOI: 10.1186/s13613-022-00979-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2617094-2
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  • 5
    Online Resource
    Online Resource
    Reference Values for IGF-I Serum Concentrations: Comparison of Six Immunoassays
    The Endocrine Society ; 2016
    In:  The Journal of Clinical Endocrinology & Metabolism Vol. 101, No. 9 ( 2016-09-01), p. 3450-3458
    Details
    In: The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society, Vol. 101, No. 9 ( 2016-09-01), p. 3450-3458
    Abstract: Measurement of IGF-I is essential for diagnosis and management of patients with disorders affecting the somatotropic axis. However, even when IGF-I kit manufacturers follow recent consensus guidelines, different kits can give very different results for a given sample. Objectives: We sought to establish normative data for six IGF-I assay kits based on a large random sample of the French general adult population. Subjects and Methods: In a cross-sectional multicenter cohort study, we measured IGF-I in 911 healthy adults (18–90 years) with six immunoassays (iSYS, LIAISON XL, IMMULITE, IGFI RIACT, Mediagnost ELISA, and Mediagnost RIA). Pairwise concordance between assays was assessed with Bland-Altman plots for both IGF-1 raw data and standard deviation scores (SDS), as well as with the percentage of observed agreement and the weighted Kappa coefficient for categorized IGF-I SDS. Results: Normative data included the range of values (2.5–97.5 percentiles) given by the six IGF-I assays according to age group and sex. A formula for SDS calculation is provided. Although the lower limits of the reference intervals of the six assays were similar, the upper limits varied markedly. Pairwise concordances were moderate to good (0.38–0.70). Conclusion: Despite being obtained in the same healthy population, the reference intervals of the six commercial IGF-1 assay kits showed noteworthy differences. Agreement between methods was moderate to good.
    Type of Medium: Online Resource
    ISSN: 0021-972X , 1945-7197
    URL: Article
    DOI: 10.1210/jc.2016-1257
    RVK:
    XA 10000
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2016
    detail.hit.zdb_id: 2026217-6
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  • 6
    Online Resource
    Online Resource
    Liquides magnétiques ou ferrofluides
    Editions Techniques de l Ingenieur ; 1995
    In:  Conversion de l'énergie électrique
    Details
    In: Conversion de l'énergie électrique, Editions Techniques de l Ingenieur
    Type of Medium: Online Resource
    URL: Journal
    URL: Article
    DOI: 10.51257/o-ti301
    DOI: 10.51257/a-v1-d2180
    Language: French
    Publisher: Editions Techniques de l Ingenieur
    Publication Date: 1995
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  • 7
    Online Resource
    Online Resource
    Static Magnetowetting of Ferrofluid Drops
    American Chemical Society (ACS) ; 2016
    In:  Langmuir Vol. 32, No. 30 ( 2016-08-02), p. 7639-7646
    Details
    In: Langmuir, American Chemical Society (ACS), Vol. 32, No. 30 ( 2016-08-02), p. 7639-7646
    Type of Medium: Online Resource
    ISSN: 0743-7463 , 1520-5827
    URL: Article
    URL: Article
    DOI: 10.1021/acs.langmuir.6b01934
    DOI: 10.1021/acs.langmuir.6b01934.s001
    RVK:
    VA 5760
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2016
    detail.hit.zdb_id: 2005937-1
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  • 8
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    Evaluation of λ-Carrageenan, CpG-ODN, Glycine Betaine, Spirulina platensis , and Ergosterol as Elicitors for Control of Zymoseptoria tritici in Wheat
    Scientific Societies ; 2019
    In:  Phytopathology® Vol. 109, No. 3 ( 2019-03), p. 409-417
    Details
    In: Phytopathology®, Scientific Societies, Vol. 109, No. 3 ( 2019-03), p. 409-417
    Abstract: Wheat crops are constantly challenged by the pathogen Zymoseptoria tritici, responsible for Septoria tritici Blotch (STB) disease. The present study reports the evaluation of five elicitor compounds (λ-carrageenan, cytosine-phosphate-guanine oligodesoxynucleotide motifs [CpG ODN], glycine betaine, Spirulina platensis, and ergosterol) for the protection of wheat against STB in order to offer new alternative tools to farmers for sustainable crop protection. Screening of elicitors of wheat defenses was carried out through a succession of experiments: biocidal in vitro tests enabled checking for any fungicidal activities, glasshouse experiments allowed determination of the efficacy of a given compound in protecting wheat against STB, and quantitative reverse-transcription polymerase chain reaction biomolecular tests investigated the relative expression of 23 defense genes in treated versus untreated plants. Therefore, we demonstrated that λ-carrageenan, CpG-ODN, glycine betaine, S. platensis, and ergosterol are potential elicitors of wheat defenses. Foliar treatment with these compounds conferred protection of wheat by up to approximately 70% against Z. tritici under semicontrolled conditions and induced both salicylic acid- and jasmonic acid-dependent signaling pathways in the plant. These findings contribute to extending the narrow list of potential elicitors of wheat defenses against Z. tritici.
    Type of Medium: Online Resource
    ISSN: 0031-949X , 1943-7684
    URL: Article
    DOI: 10.1094/PHYTO-11-17-0367-R
    Language: English
    Publisher: Scientific Societies
    Publication Date: 2019
    detail.hit.zdb_id: 2037027-1
    SSG: 12
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  • 9
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    Online Resource
    Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice
    American Physiological Society ; 2009
    In:  American Journal of Physiology-Endocrinology and Metabolism Vol. 297, No. 2 ( 2009-08), p. E438-E451
    Details
    In: American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 297, No. 2 ( 2009-08), p. E438-E451
    Abstract: In human thyroid, caveolin-1 is localized at the apex of thyrocytes, but its role there remains unknown. Using immunohistochemistry, 127 I imaging, transmission electron microscopy, immunogold electron microscopy, and quantification of H 2 O 2 , we found that in caveolin-1 knockout mice thyroid cell homeostasis was disrupted, with evidence of oxidative stress, cell damage, and apoptosis. An even more striking phenotype was the absence of thyroglobulin and iodine in one-half of the follicular lumina and their presence in the cytosol, suggesting that the iodide organification and binding to thyroglobulin were intracellular rather than at the apical membrane/extracellular colloid interface. The latter abnormality may be secondary to the observed mislocalization of the thyroid hormone synthesis machinery (dual oxidases, thyroperoxidase) in the cytosol. Nevertheless, the overall uptake of radioiodide, its organification, and secretion as thyroid hormones were comparable to those of wild-type mice, suggesting adequate compensation by the normal TSH retrocontrol. Accordingly, the levels of free thyroxine and TSH were normal. Only the levels of free triiodothyronine showed a slight decrease in caveolin-1 knockout mice. However, when TSH levels were increased through low-iodine chow and sodium perchlorate, the induced goiter was more prominent in caveolin-1 knockout mice. We conclude that caveolin-1 plays a role in proper thyroid hormone synthesis as well as in cell number homeostasis. Our study demonstrates for the first time a physiological function of caveolin-1 in the thyroid gland. Because the expression and subcellular localization of caveolin-1 were similar between normal human and murine thyroids, our findings in caveolin-1 knockout mice may have direct relevance to the human counterpart.
    Type of Medium: Online Resource
    ISSN: 0193-1849 , 1522-1555
    URL: Article
    DOI: 10.1152/ajpendo.90784.2008
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2009
    detail.hit.zdb_id: 1477331-4
    SSG: 12
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  • 10
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    Clinical Benefit of Extubation in Patients on Venoarterial Extracorporeal Membrane Oxygenation
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Critical Care Medicine Vol. 50, No. 5 ( 2022-05), p. 760-769
    Details
    In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. 5 ( 2022-05), p. 760-769
    Abstract: Although patients on venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock are usually supported with mechanical ventilation, it is not clear whether sedation cessation and extubation might improve outcomes. DESIGN: Retrospective cohort study with propensity score overlap weighting analysis. SETTING: Three ICUs in a 1,500-bed tertiary university hospital. PATIENTS: From an overall cohort of 641 patients with venoarterial-extracorporeal membrane oxygenation support, the primary analysis was performed in 344 patients who had been successfully decannulated in order to reduce immortal time bias. MEASUREMENTS AND MAIN RESULTS: Seventy-five patients (22%) were extubated during extracorporeal membrane oxygenation support and were subsequently decannulated alive. Forty-nine percent received noninvasive ventilation, and 25% had emergency reintubation for respiratory, neurologic, or hemodynamic reasons. Higher Simplified Acute Physiology Score II at admission (odds ratio, 0.97; 95% CI [0.95–0.99]; p = 0.008) was associated with a lower probability of extubation, whereas cannulation in cardiac surgery ICU (odds ratio, 3.14; 95% CI [1.21–8.14]; p = 0.018) was associated with an increased probability. Baseline characteristics were well balanced after propensity score overlap weighting. The number of ICU-free days within 30 days of extracorporeal membrane oxygenation decannulation was significantly higher among extubated patients compared with nonextubated patients (22 d [11–26 d] vs 18 d [7–25 d] , respectively; p = 0.036). There were no differences in other outcomes including ventilator-associated pneumonia (odds ratio, 0.96; 95% CI [0.51–1.82]; p = 0.90) and all-cause mortality within 30 days of extracorporeal membrane oxygenation decannulation (5% vs 17%; hazard ratio, 0.54; 95% CI [0.19–1.59]; p = 0.27). As a secondary analysis, outcomes were compared in the overall cohort of 641 venoarterial extracorporeal membrane oxygenation–supported patients. Results were consistent with the primary analysis as extubated patients had a higher number of ICU-free days (18 d [0–24 d] vs 0 d [0–18 d] , respectively; 〈 0.001) and a lower risk of death within 30 days of extracorporeal membrane oxygenation cannulation (hazard ratio, 0.45; 95% CI [0.29–0.71]; p = 0.001). CONCLUSIONS: Extubation during venoarterial-extracorporeal membrane oxygenation support is safe, feasible, and associated with greater ICU-free days.
    Type of Medium: Online Resource
    ISSN: 0090-3493
    URL: Article
    DOI: 10.1097/CCM.0000000000005304
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2034247-0
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