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  • 1
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    Subchronic Toxicity Study of Alternanthera philoxeroides in Swiss Albino Mice Having Antioxidant and Anticoagulant Activities
    Hindawi Limited ; 2022
    In:  Journal of Toxicology Vol. 2022 ( 2022-7-13), p. 1-12
    Details
    In: Journal of Toxicology, Hindawi Limited, Vol. 2022 ( 2022-7-13), p. 1-12
    Abstract: Alternanthera philoxeroides, a tropical herb and edible vegetable, has been popular as a medicinal plant. Applying in vitro approach, we initially attempted to assess the phytochemicals, bioactive chemicals, as well as antioxidant and anticoagulant activities of this plant. Following that, the in vivo toxicological effects of methanolic extracts of A. philoxeroides using different doses on the kidney, heart, lung, liver, stomach, brain, and blood of female Swiss Albino mice were investigated. We estimated phytochemicals content as well as antioxidant activity through DPPH, NO, CUPRAC, and reducing power assays, followed by the anticoagulant activities of PT  and aPTT  and bioactive compounds using HPLC. To confirm the biocompatibility of A. philoxeroides extracts, histopathological and hematological parameters were examined in a mice model. Total phenol, flavonoid, and tannin content in A. philoxeroides was 181.75 ± 2.47 mg/g, 101.5 ± 3 .53 mg/g, and 68.58 ± 0.80 mg/g, respectively. Furthermore, the HPLC study confirmed the presence of four phenolic compounds: catechin, tannic acid, gallic acid, and vanillic acid. The methanolic extract of A. philoxeroides showed considerable antioxidant activity in all four antioxidant assay methods when compared to the standard. In comparison to ascorbic acid, A. philoxeroides also demonstrated a minor concentration-dependent ferric and cupric reduction activity. In vivo evaluation indicated that A. philoxeroides extracts (doses: 250, 500, and 1000 mg/kg) had no negative effects on the relative organ or body weight, or hematological indicators. Our study concluded that A. philoxeroides had significant antioxidant and anticoagulant activities and demonstrated no negative effects on the body or relative organ weight, histopathological, and hematological indices in the mouse model.
    Type of Medium: Online Resource
    ISSN: 1687-8205 , 1687-8191
    URL: Article
    DOI: 10.1155/2022/8152820
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2495098-1
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  • 2
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    Understanding Bacterial Isolates in Blood Culture and Approaches Used to Define Bacteria as Contaminants : A Literature Review
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Pediatric Infectious Disease Journal Vol. 35, No. 5 ( 2016-05), p. S45-S51
    Details
    In: Pediatric Infectious Disease Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 35, No. 5 ( 2016-05), p. S45-S51
    Type of Medium: Online Resource
    ISSN: 0891-3668
    URL: Article
    DOI: 10.1097/INF.0000000000001106
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2020216-7
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  • 3
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    Abstract 5025: Reduced level of protein kinase C iota renders human glioblastoma less invasive and induces apoptosis via modulating Tak1/NF-κB pathway
    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Research Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5025-5025
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5025-5025
    Abstract: Glioblastoma (GBM) is characterized by poor therapeutic response and overall survival. It is the most aggressive form of primary brain tumor with a tendency to invade surrounding healthy brain tissues, rendering them largely incurable. In this study, small-interference RNA was used to knock down the expression of protein kinase C PKC-ι. The reduced PKC-ι expression impaired the phosphorylation of LIM kinase 1/2 (LIMK), which is a critical step in cofilin recycling and actin polymerization. Additionally, there was a down-regulation of matrix metalloprotease-9 expression in LN-229 and U87G cells, which coincided with decreased invasion. Therefore, PKC-ι regulates both cytoskeleton rearrangement and cell adhesion, which contributed to cell migration. Silencing of PKC-ι also dampened Transforming growth factor-β (TGF-β)-activated kinase 1 (Tak1) level. TAK1 is an essential component in genotoxic stresses-induced NF-κB-activation and mitogen-activated protein kinase (MAPK)-pathways in GBM. TAK1, when activated, forms a complex with TAB1-3 (Tak1 binding proteins). Our data reveal, reduced Tak1 level after silencing PKC-ι interferes with complex formation and reduces NF-κB-activation. Diminished PKC-ι level also reduces activation of Tak1/JNK axis. This deactivation exerts an anti-oncogenic effect on glioblastoma via suppression of Akt1, c-Myc, and STAT3. This implies PKC-ι may have a crucial role in the activation of Tak1. Reduced migration and invasion in glioblastoma cells upon inhibition of PKC-ι was further confirmed by Scratch assay and Boyden assay. These results indicate that PKC-ι is involved in the control of glioblastoma cell migration and invasion. PKC-ι is a central component of multiple converging and bifurcating pathways and is a potential therapeutic target against GBM survival and infiltration. Citation Format: Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Avijit Dey, Nuzhat N. Oishee, Mahfuza Marzan, Mildred Acevedo-Duncan. Reduced level of protein kinase C iota renders human glioblastoma less invasive and induces apoptosis via modulating Tak1/NF-κB pathway. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5025.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2023-5025
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 4
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    Abstract 5024: Role of protein kinase C ζ and ι inhibitors on ovarian cancer cell lines in combination with cisplatin
    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Research Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5024-5024
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 5024-5024
    Abstract: Ovarian cancer causes more death than any other cancers of the female reproductive system. Current treatment strategies are surgical removal of cancerous parts and chemotherapy with platinum drugs (e.g. cisplatin, carboplatin) or taxols. However, recurrence of cancer with drug resistance is frequent. Previously two inhibitors; ICA-1S (5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide and ζ-stat (8-hydroxy-1,3,6- naphthalenetrisulfonic acid) specific for two atypical protein kinases, PKC-ι and PKC-ζ respectively have been reported. These inhibitors have an anticancer effect in different cancers, including clear-cell ovarian cancer. Our aim was to find if cisplatin has any synergistic effect with ICA-1S and ζ-stat on ovarian cancer cell proliferation, migration, and apoptosis. Ovarian cancer cell line ES-2, which has mutation in p53 gene was used in this study. After 72 hours of treatment with ICA-1S (10 µM) and ζ-stat (10 µM), proliferation of ES-2 cell line was inhibited by 42.5% and 23.5% respectively compared to control. When combined with cisplatin (0.5 µM), the inhibition of cell proliferation increased to 67% for ζ-stat and 65.8% for ICA-1S (N=3 trials) which is synergistic. Wound healing assay with ES-2 cells showed that ICA-1S and cisplatin inhibited the migration of ES-2 cells separately as well as in combination. SDS-PAGE and subsequent western blotting showed that ICA-1S monotherapy and combination with cisplatin reduced the expression mutant p53, PI3K, AKT, Bcl2, and phopho-BAD. IP with PKC ζ beads showed the association of PKC ζ with PKC-ι and p53 in ES-2 cell line. As mutation in p53 is quite frequent in ovarian cancer with gain of function, ICA-1S may have an advantageous role in inhibiting mutated p53 regulated pathway. Inhibition of ES-2 cell line with ICA-1S and ζ-stat also suggested that PKC-ι and PKC ζ play important roles in ovarian cancer and may augment traditional chemotherapy. Further study on the pathway affected by aPKC inhibitors combined with cisplatin would be investigated through WST, western blotting and immunoprecipitation assay. Citation Format: Mahfuza Marzan, Nuzhat Nowshin Oishee, Khandker Mohammad Khalid, Mildred Acevedo-Duncan. Role of protein kinase C ζ and ι inhibitors on ovarian cancer cell lines in combination with cisplatin. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5024.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2023-5024
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
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    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 5
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    Prevalence of Drug-Resistant Tuberculosis in Sudan: A Systematic Review and Meta-Analysis
    MDPI AG ; 2021
    In:  Antibiotics Vol. 10, No. 8 ( 2021-07-31), p. 932-
    Details
    In: Antibiotics, MDPI AG, Vol. 10, No. 8 ( 2021-07-31), p. 932-
    Abstract: Drug-resistant tuberculosis (DR-TB) is still one of the most critical issues impeding worldwide TB control efforts. The aim of this systematic review and meta-analysis was to give an updated picture of the prevalence of DR-TB in Sudan. A comprehensive systematic search was performed on four electronic databases (PubMed, Scopus, Web of Science and Google Scholar) to identify all published studies reporting prevalence data of DR-TB in Sudan. Sixteen eligible studies published during 2002–2020 were included. Using meta-analysis of proportions, the pooled prevalence of TB cases with resistance to any anti-TB drugs was 47.0% (95% CI: 35.5–58.6%). The overall prevalence of mono, multi, poly and extensive drug resistance were estimated to be 16.2% (95% CI: 9.0–23.4%), 22.8% (95% CI: 16.0–29.7%), 6.8% (95% CI: 0.5–13.0%) and 0.7% (95% CI: 0–2.1%), respectively. Considering any first-line anti-TB drugs, the resistance prevalence was highest for isoniazid (32.3%) and streptomycin (31.7%), followed by rifampicin (29.2%). In contrast, resistance against second-line drugs was reported for only two antibiotics, namely, ofloxacin (2.1%) and kanamycin (0.7%). Of note, the resistance profile of the previously treated patients was found to be remarkably high compared with the newly diagnosed TB patients. The relatively high prevalence estimation of anti-TB drug resistance warrants strengthening TB control and treatment strategies in Sudan.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    URL: Article
    DOI: 10.3390/antibiotics10080932
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2681345-2
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  • 6
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    Synergism of Phyllanthus niruni Extract with Gentamicin against Methicillin Resistant Staphylococcus aureus
    Sciencedomain International ; 2018
    In:  European Journal of Medicinal Plants Vol. 25, No. 3 ( 2018-10-23), p. 1-7
    Details
    In: European Journal of Medicinal Plants, Sciencedomain International, Vol. 25, No. 3 ( 2018-10-23), p. 1-7
    Type of Medium: Online Resource
    ISSN: 2231-0894
    URL: Journal
    URL: Article
    DOI: 10.9734/EJMP
    DOI: 10.9734/EJMP/2018/44442
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2018
    detail.hit.zdb_id: 2633136-6
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  • 7
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    Rotavirus Surveillance at a WHO-Coordinated Invasive Bacterial Disease Surveillance Site in Bangladesh: A Feasibility Study to Integrate Two Surveillance Systems
    Public Library of Science (PLoS) ; 2016
    In:  PLOS ONE Vol. 11, No. 4 ( 2016-4-20), p. e0153582-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 4 ( 2016-4-20), p. e0153582-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0153582
    DOI: 10.1371/journal.pone.0153582.g001
    DOI: 10.1371/journal.pone.0153582.g002
    DOI: 10.1371/journal.pone.0153582.g003
    DOI: 10.1371/journal.pone.0153582.t001
    DOI: 10.1371/journal.pone.0153582.t002
    DOI: 10.1371/journal.pone.0153582.s001
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2016
    detail.hit.zdb_id: 2267670-3
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  • 8
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    Prevalence of Antibiotic-Resistant Pulmonary Tuberculosis in Bangladesh: A Systematic Review and Meta-Analysis
    MDPI AG ; 2020
    In:  Antibiotics Vol. 9, No. 10 ( 2020-10-17), p. 710-
    Details
    In: Antibiotics, MDPI AG, Vol. 9, No. 10 ( 2020-10-17), p. 710-
    Abstract: Resistance to anti-tuberculosis (anti-TB) antibiotics is a major public health concern for many high-TB burden countries in Asia, including Bangladesh. Therefore, to represent the overall drug-resistance pattern against TB in Bangladesh, a systematic review and meta-analysis was conducted. Databases such as PubMed, Scopus, and Google Scholar were searched to identify studies related to antibiotic-resistant TB. A total of 24 studies covering 13,336 patients with TB were secured and included. The random-effects model was used to calculate the summary estimates. The pooled prevalence of any, mono, multi, poly, and extensive anti-TB antibiotic-resistances were 45.3% [95% CI: 33.5–57.1], 14.3% [95% CI: 11.4–17.2] , 22.2% [95% CI: 18.8–25.7], 7.7% [95% CI: 5.6–9.7] , and 0.3% [95% CI: 0.0–1.0], respectively. Among any first and second-line anti-TB drugs , isoniazid (35.0%) and cycloserine (44.6%) resistances were the highest, followed by ethambutol (16.2%) and gatifloxacin (0.2%). Any, multi, and poly drug-resistances were higher in retreatment cases compared to the newly diagnosed cases, although mono drug-resistance tended to be higher in newly diagnosed cases (15.7%) than that in retreatment cases (12.5%). The majority (82.6%) of the included studies were of high quality, with most not exhibiting publication bias. Sensitivity analyses confirmed that all outcomes are robust and reliable. It is concluded that resistance to anti-TB drugs in Bangladesh is rampant and fast growing. Therefore, the implementation of a nationwide surveillance system to detect suspected and drug-resistant TB cases, as well as to ensure a more encompassing treatment management by national TB control program, is highly recommended.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    URL: Article
    DOI: 10.3390/antibiotics9100710
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2681345-2
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  • 9
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    Prevalence of Antibiotic-Resistant Shigella spp. in Bangladesh: A Systematic Review and Meta-Analysis of 44,519 Samples
    MDPI AG ; 2023
    In:  Antibiotics Vol. 12, No. 5 ( 2023-04-26), p. 817-
    Details
    In: Antibiotics, MDPI AG, Vol. 12, No. 5 ( 2023-04-26), p. 817-
    Abstract: Shigella is the leading global etiological agent of shigellosis, especially in poor and underdeveloped or developing nations with insufficient sanitation such as Bangladesh. Antibiotics are the only treatment option for the shigellosis caused by Shigella spp. as no effective vaccine exists. However, the emergence of antimicrobial resistance (AMR) poses a serious global public health concern. Therefore, a systematic review and meta-analysis were conducted to establish the overall drug resistance pattern against Shigella spp. in Bangladesh. The databases of PubMed, Web of Science, Scopus, and Google Scholar were searched for relevant studies. This investigation comprised 28 studies with 44,519 samples. Forest and funnel plots showed any-drug, mono-drug, and multi-drug resistance. Any fluoroquinolone had a resistance rate of 61.9% (95% CI: 45.7–83.8%), any trimethoprim–sulfamethoxazole—60.8% (95% CI: 52.4–70.5%), any azithromycin—38.8% (95% CI: 19.6–76.9%), any nalidixic acid—36.2% (95% CI: 14.2–92.4%), any ampicillin—34.5% (95% CI: 25.0–47.8%), and any ciprofloxacin—31.1% (95% CI: 11.9–81.3%). Multi-drug-resistant Shigella spp. exhibited a prevalence of 33.4% (95% CI: 17.3–64.5%), compared to 2.6% to 3.8% for mono-drug-resistant strains. Since resistance to commonly used antibiotics and multidrug resistance were higher, a judicious use of antibiotics, the promotion of infection control measures, and the implementation of antimicrobial surveillance and monitoring programs are required to tackle the therapeutic challenges of shigellosis.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    URL: Article
    DOI: 10.3390/antibiotics12050817
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2681345-2
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  • 10
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    Knowledge, Attitudes, and Practices in Relation to Mosquito-Borne Diseases in Bangladesh
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 14 ( 2022-07-06), p. 8258-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 14 ( 2022-07-06), p. 8258-
    Abstract: Mosquito-borne diseases (MBDs) such as dengue, malaria, and chikungunya are common in Bangladesh, with frequent outbreaks in the rainy season. Analysis of the knowledge, attitudes, and practices of people toward any crisis is fundamental to addressing any gap. Here, we conducted a cross-sectional study mainly focusing on the northern, southern and central parts of Bangladesh to understand the level of knowledge, attitudes, and practices of people regarding MBDs, mosquito habitats, or control measures. A total of 1720 participants were involved in the study from 33 out of 64 districts of Bangladesh, of which 56.9% were male. While most of them knew about dengue (97.1%), chikungunya (81.4%), and malaria (85.2%), only half of them were aware of filaria (53.3%), which is endemic to the northern region. A knowledge score (0–8, low), (9–16, moderate), (17–24, high), and attitude score (0–4, poor), (5–8, moderate), and (9–13, high) were assigned. While poor and moderate attitudes were considered negative, good attitudes were considered positive. About 45% of the respondents had a moderate knowledge score (50–70); however, about 67.9% of participants showed a good attitude score ( 〉 70) towards the control of MBDs. It was found that the knowledge and attitude of the responders were related to their profession (knowledge p 〈 0.001; attitude, p = 0.002), residential area (knowledge p 〈 0.001; attitude, p 〈 0.001), and education level (knowledge p 〈 0.001; attitude p = 0.004). A mosquito is a kind of nuisance bug, and about 79.8% of responders admitted that they kill mosquitoes as soon as they notice them. They also use bed nets (93.7%) followed by mosquito coils (85.7%) as a preventive method. Interestingly, 73.2% of the responders were reluctant to contact the local government during an increase in mosquito numbers. Overall, the people of Bangladesh have a positive attitude towards the prevention of mosquito-borne diseases. It is highly recommended that the government creates more knowledge regarding this issue and develops collaborative approaches with local people to implement robust preventive measures against mosquito-borne diseases.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19148258
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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