In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2021-3-23), p. e0249073-
Abstract:
A smoking habit can cause various health problems encompassing retinal diseases including central serous chorioretinopathy (CSC). The aim of the current study was to investigate the effect of smoking on the choroidal structure in patients with CSC. Methods The choroidal vascular index (CVI) was calculated using the binarized OCT images. Baseline parameters (age, refractive error [SE], subfoveal choroidal thickness [SFCT] and CVI) were compared between smokers and non-smokers using Wilcoxon rank sum test. Moreover, the associations between SFCT and the baseline parameters were analyzed using a multivariate linear regression followed by the AICc model selection. Results Among 75 CSC patients, 45 patients were smokers and 30 patients were non-smokers. No significant differences in age and SE were seen between the smoking group and the non-smoking group. A significant difference in the SFCT was seen between two groups (382.0 ± 68.2 μm in the smoking group vs. 339.3 ± 52.3 μm in the non-smoking group, p = 0.0038), while no significant difference was observed in the CVI ( p = 0.32). The optimal model for SFCT included the variables of age, SE and past history of smoking among the baseline parameters. Additionally, increased pack years was associated with increased SFCT. Conclusion Cigarette smoking was associated with an increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may be an important modulator of the disease.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0249073
DOI:
10.1371/journal.pone.0249073.g001
DOI:
10.1371/journal.pone.0249073.g002
DOI:
10.1371/journal.pone.0249073.g003
DOI:
10.1371/journal.pone.0249073.t001
DOI:
10.1371/journal.pone.0249073.t002
DOI:
10.1371/journal.pone.0249073.t003
DOI:
10.1371/journal.pone.0249073.s001
DOI:
10.1371/journal.pone.0249073.s002
DOI:
10.1371/journal.pone.0249073.s003
DOI:
10.1371/journal.pone.0249073.r001
DOI:
10.1371/journal.pone.0249073.r002
DOI:
10.1371/journal.pone.0249073.r003
DOI:
10.1371/journal.pone.0249073.r004
DOI:
10.1371/journal.pone.0249073.r005
DOI:
10.1371/journal.pone.0249073.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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