In:
Cardiology, S. Karger AG, Vol. 113, No. 3 ( 2009), p. 172-179
Abstract:
〈 i 〉 Objectives: 〈 /i 〉 To determine, in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI), the mechanisms and clinical implications of the acute changes in QT dispersion (QTd). 〈 i 〉 Methods: 〈 /i 〉 In this prospective study we included 216 patients admitted with a STEMI of 〈 12 h of evolution. All were treated with PPCI. QTd was measured prior to PPCI and within 1 h after. 〈 i 〉 Results: 〈 /i 〉 The ratio of QTd reduction after PPCI (QTd-R) – defined as [(QTd before PPCI – QTd after PPCI)/QTd before PPCI] ×100 – was significantly correlated with the percentage of ST-segment elevation resolution (ST-R; p 〈 0.001). To determine the significance of the different values of QTd-R, we further subdivided our population into 3 groups according to the tertiles of QTd-R ( 〈 10, 11–49, ≥50%). Patients with longer QTd-R had higher percentages of ST-R: 32 ± 43 for QTd-R 〈 10% vs. 60 ± 21 for 11–49% vs. 71 ± 12 for ≥50% (p 〈 0.05). By logistic regression, patients with QTd-R ≥50% had a reduction of 75% in the adjusted frequency of death or severe heart failure during hospitalization (95% CI 13–73%, p = 0.03). 〈 i 〉 Conclusion: 〈 /i 〉 QTd-R after PPCI occurs early, is closely related to the restoration of reperfusion at the microvascular level and provides additional prognostic information.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1482041-9
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