In:
The Journal of Clinical Hypertension, Wiley, Vol. 21, No. 9 ( 2019-09), p. 1360-1369
Abstract:
Studies aiming to associate the sodium/potassium (Na/K) ratio with hypertension use 24‐hour urinary excretion as a daily marker of ingestion. The objective of this study was to evaluate the association between urinary Na/K ratio and structural and functional vascular alterations in non‐diabetic hypertensive patients. In hypertensive patients (n = 72), aged between 40 and 70 years, both sexes (61% women), in use of hydrochlorothiazide, we measured blood pressure, 24‐hour urine sample collection, assessment of carotid‐femoral pulse wave velocity (cf‐PWV, Complior), central hemodynamic parameters (SphygmoCor), and post‐occlusive reactive hyperemia (PORH). The participants were divided according to the tertile of 24‐hour urinary Na/K ratio. Each group contained 24 patients. Systolic blood pressure was higher in T2 (133 ± 9 vs 140 ± 9 mmHg, P = .029). C‐reactive protein (CRP) presented higher values in T3 as compared to T1 [0.20(0.10‐0.34) vs 1.19 (0.96‐1.42) mg/dL, P 〈 .001]. Higher values in T3 were also observed for aortic systolic pressure (aoSP) [119(114‐130) vs 135(125‐147) mmHg, P = .002] and cf‐PWV (9.2 ± 1.6 vs 11.1 ± 1.5 m/s, P 〈 .001). The urinary Na/K ratio presented significant correlations with proteinuria ( r = .27, P = .023), CRP ( r = .77, P 〈 .001), cf‐PWV ( r = .41, P 〈 .001), and post‐occlusive reactive hyperemia on cutaneous vascular conductance (PORH CVC) ( r = −.23, P = .047). By multivariate linear regression, it was detected an independent and significant association of cf‐PWV with urinary Na/K ratio ( R 2 = 0.17, P 〈 .001) and PORH CVC with CRP ( R 2 = 0.30, P = .010). Our data indicated that increased urinary Na/K ratio in non‐diabetic hypertensive patients was associated with higher degree of inflammation, raised peripheral and central pressure levels, and changes suggestive of endothelial dysfunction and arterial stiffness.
Type of Medium:
Online Resource
ISSN:
1524-6175
,
1751-7176
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2058690-5
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