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  • 1
    Online Resource
    Online Resource
    Proceedings of the Frontiers of Retrovirology Conference 2016
    Springer Science and Business Media LLC ; 2016
    In:  Retrovirology Vol. 13, No. S1 ( 2016-9)
    Details
    In: Retrovirology, Springer Science and Business Media LLC, Vol. 13, No. S1 ( 2016-9)
    Type of Medium: Online Resource
    ISSN: 1742-4690
    URL: Article
    DOI: 10.1186/s12977-016-0294-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2142602-8
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.
    The American Association of Immunologists ; 1986
    In:  The Journal of Immunology Vol. 137, No. 9 ( 1986-11-01), p. 2925-2929
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 137, No. 9 ( 1986-11-01), p. 2925-2929
    Abstract: The stimulation of the human neutrophil NADPH-oxidase is initiated by a variety of agonists, which appear to utilize more than one activation pathway. We have discerned that opsonized zymosan (OZ) stimulates O2- release by a mechanism distinct from that of phorbol myristate acetate (PMA). PMA differs from OZ stimulation in its susceptibility to H-7 (a protein kinase inhibitor) inhibition of O2- release and the lack of PMA-initiated release of radiolabeled arachidonic acid ([3H]AA) from prelabeled cells. That AA release was linked to O2- generation in OZ-stimulated cells was suggested by the finding that mepacrine, a phospholipase inhibitor, exhibits parallel dose response inhibition for both O2- generation and [3H] AA release, whereas mepacrine did not significantly inhibit the O2- generation induced by PMA. The specific involvement of phospholipase A2 (PLA2) in the release of AA was indicated by the lack of release of [3H]oleate, which is not released by PLA2 in intact cells; [3H] AA released from phosphatidylinositol and phosphatidylcholine and not accompanied by the formation of [3H]-arachidonyl phosphatidic acid, thus eliminating the involvement of phospholipase C; and the inhibition of [3H] AA release by p-bromophenacyl bromide, a specific PLA2 inhibitor. The reduction of O2- formation by inhibitors of AA metabolism (BW755C, acetylsalicylic acid, and indomethacin) further supports a linkage between AA release and O2- generation. That [3H]AA release, like O2- generation, in OZ-stimulated cells was calcium dependent further differentiates OZ from calcium-indepe ndent PMA activation. These studies in toto suggest that OZ stimulation of the NADPH-oxidase differs from PMA, in that the particulate stimulus is PLA2 mediated and independent of protein kinase C.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.137.9.2925
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 1986
    detail.hit.zdb_id: 1475085-5
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  • 3
    Online Resource
    Online Resource
    Coiling Phagocytosis of Trypanosomatids and Fungal Cells
    American Society for Microbiology ; 1998
    In:  Infection and Immunity Vol. 66, No. 9 ( 1998-09), p. 4331-4339
    Details
    In: Infection and Immunity, American Society for Microbiology, Vol. 66, No. 9 ( 1998-09), p. 4331-4339
    Abstract: Coiling phagocytosis has previously been studied only with the bacteria Legionella pneumophila and Borrelia burgdorferi , and the results were inconsistent. To learn more about this unconventional phagocytic mechanism, the uptake of various eukaryotic microorganisms by human monocytes, murine macrophages, and murine dendritic cells was investigated in vitro by video and electron microscopy. Unconventional phagocytosis of Leishmania spp. promastigotes, Trypanosoma cruzi trypomastigotes, Candida albicans hyphae, and zymosan particles from Saccharomyces cerevisiae differed in (i) morphology (rotating unilateral pseudopods with the trypanosomatids, overlapping bilateral pseudopods with the fungi), (ii) frequency (high with Leishmania ; occasional with the fungi; rare with T. cruzi ), (iii) duration (rapid with zymosan; moderate with the trypanosomatids; slow with C. albicans ), (iv) localization along the promastigotes (flagellum of Leishmania major and L. aethiopica ; flagellum or posterior pole of L. donovani ), and (v) dependence on complement (strong with L. major and L. donovani ; moderate with the fungi; none with L. aethiopica ). All of these various types of unconventional phagocytosis gave rise to similar pseudopod stacks which eventually transformed to a regular phagosome. Further video microscopic studies with L. major provided evidence for a cytosolic localization, synchronized replication, and exocytic release of the parasites, extending traditional concepts about leishmanial infection of host cells. It is concluded that coiling phagocytosis comprises phenotypically similar consequences of various disturbances in conventional phagocytosis rather than representing a single separate mechanism.
    Type of Medium: Online Resource
    ISSN: 0019-9567 , 1098-5522
    URL: Article
    DOI: 10.1128/IAI.66.9.4331-4339.1998
    RVK:
    XA 10000
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1998
    detail.hit.zdb_id: 1483247-1
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  • 4
    Online Resource
    Online Resource
    Annexin 3 is associated with cytoplasmic granules in neutrophils and monocytes and translocates to the plasma membrane in activated cells
    Portland Press Ltd. ; 1994
    In:  Biochemical Journal Vol. 303, No. 2 ( 1994-10-15), p. 481-487
    Details
    In: Biochemical Journal, Portland Press Ltd., Vol. 303, No. 2 ( 1994-10-15), p. 481-487
    Abstract: Annexins are soluble proteins capable of binding to phospholipid membranes in a calcium-dependent manner. Annexin 3, a 33 kDa protein mainly expressed in neutrophils, aggregates granules in cell-free assays, and a 36 kDa variant of this protein, specifically expressed in monocytes, has recently been identified. To obtain further information on these proteins, we defined their subcellular localization in resting and activated cells by immunofluorescence microscopy. Both proteins were associated with cytoplasmic granules in resting cells. We obtained evidence to indicate that, in neutrophils which possess a heterogenous granule population, annexin 3 was more likely to be associated with the specific granules. In cells activated with phorbol 12-myristate 13-acetate or opsonized zymosan, the 33 kDa and 36 kDa proteins translocated to the plasma or the phagosome membrane. Upon stimulation with A23187, annexin 3 translocated to the plasma membrane only in neutrophils. We also report that while annexin 3 was associated with restricted membranes in intact cells, it binds indiscriminately to every membrane fraction in cell-free assay. In conclusion, association of both forms of annexin 3 with granules suggests that these proteins could be implicated in processes of granule fusion.
    Type of Medium: Online Resource
    ISSN: 0264-6021 , 1470-8728
    URL: Article
    DOI: 10.1042/bj3030481
    RVK:
    WA 15000
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 1994
    detail.hit.zdb_id: 1473095-9
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    PAF inhalation induce bronchoconstriction, alveolar macrophage activation and specific desensitization
    Elsevier BV ; 1985
    In:  Prostaglandins Vol. 30, No. 4 ( 1985-10), p. 704-
    Details
    In: Prostaglandins, Elsevier BV, Vol. 30, No. 4 ( 1985-10), p. 704-
    Type of Medium: Online Resource
    ISSN: 0090-6980
    URL: Article
    DOI: 10.1016/0090-6980(85)90048-6
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1985
    detail.hit.zdb_id: 2140297-8
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig
    Elsevier BV ; 1985
    In:  Biochemical and Biophysical Research Communications Vol. 131, No. 1 ( 1985-08), p. 42-49
    Details
    In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 131, No. 1 ( 1985-08), p. 42-49
    Type of Medium: Online Resource
    ISSN: 0006-291X
    URL: Article
    DOI: 10.1016/0006-291X(85)91767-X
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1985
    detail.hit.zdb_id: 1461396-7
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    The src -family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation
    Portland Press Ltd. ; 1995
    In:  Biochemical Journal Vol. 309, No. 2 ( 1995-07-15), p. 657-665
    Details
    In: Biochemical Journal, Portland Press Ltd., Vol. 309, No. 2 ( 1995-07-15), p. 657-665
    Abstract: The src-family protein-tyrosine kinase p59hck is mainly expressed in neutrophils; however, its functional role in these cells is unknown. Several other src-family members are localized on secretory vesicles and have been proposed to regulate intracellular traffic. We have established here the subcellular localization of p59hck in human neutrophils. Immunoblotting of subcellular fractions showed that approx. 60% of the p59hck per cell is localized on the secretory granules; the other 40% is distributed equally between non-granular membranes and the cytosol. Immunofluorescence of neutrophils and HL60 cells suggests that the p59hck-positive granules are azurophil granules. Granular p59hck is highly susceptible to degradation by an azurophil-granule proteinase. Different forms of p59hck occur in the three subcellular compartments: a 61 kDa form is mainly found in the granules, a 59 kDa form is predominant in the non-granular membranes, whereas cytosolic p59hck migrates as a doublet at 63 kDa. During the process of phagocytosis-linked degranulation, induced by serum-opsonized zymosan in neutrophils or HL60 cells, granular p59hck translocates towards the phagosome. The subcellular localization of p59hck suggests that the enzyme could be involved in the regulation of the degranulation process.
    Type of Medium: Online Resource
    ISSN: 0264-6021 , 1470-8728
    URL: Article
    DOI: 10.1042/bj3090657
    RVK:
    WA 15000
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 1995
    detail.hit.zdb_id: 1473095-9
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    The Role of the Na+/H+ Antiporter in Human Neutrophil NADPH-Oxidase Activation
    Oxford University Press (OUP) ; 1988
    In:  Journal of Leukocyte Biology Vol. 43, No. 2 ( 1988-02-01), p. 183-186
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 43, No. 2 ( 1988-02-01), p. 183-186
    Abstract: The Na+/H+ antiporter has been shown to regulate activation of the human neutrophil. To delineate the role of the antiporter in the stimulation cascade, superoxide ((O2−) generation was observed in PMA-stimulated neutrophils in which intracellular pH (pHI) was artificially manipulated by the use of nigericin, a K+/H+ ionophore, with and without use of the Na+/H+ antiporter inhibitor, dimethyiamiloride (DA). Decreased O2− generation was observed in a Na+-free, 140 mM K+ buffer, but addition of nigericin restored this parameter of neutrophil activation to levels found in physiologic Na+ media. Further, the inhibitory effects of DA on O2− generation by cells incubated in a 10 mM Na+, 130 mM K+ buffer were totally reversed by a similar concentration of nigericin. O2− generated by a membrane preparation of the NADPH-oxidase, made from cells incubated under the same experimental conditions, paralleled whole cell studies, but the activity of the oxidase did not vary when suspended in the various reaction mixtures. These experiments support the role of the Na+/H+ antiporter in neutrophil activation as a metabolic regulator of pHi that Influences receptor-coupled reactions proximal to expression of the NADPH-oxidase itself.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.43.2.183
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1988
    detail.hit.zdb_id: 2026833-6
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Trimetazidine protects the human red blood cell aganst oxygen free radical damage
    Springer Science and Business Media LLC ; 1990
    In:  Cardiovascular Drugs and Therapy Vol. 4, No. S4 ( 1990-8), p. 818-819
    Details
    In: Cardiovascular Drugs and Therapy, Springer Science and Business Media LLC, Vol. 4, No. S4 ( 1990-8), p. 818-819
    Type of Medium: Online Resource
    ISSN: 0920-3206 , 1573-7241
    URL: Article
    DOI: 10.1007/BF00051284
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1990
    detail.hit.zdb_id: 2003553-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    The Mannose Receptor Mediates Uptake of Pathogenic and Nonpathogenic Mycobacteria and Bypasses Bactericidal Responses in Human Macrophages
    American Society for Microbiology ; 1999
    In:  Infection and Immunity Vol. 67, No. 2 ( 1999-02), p. 469-477
    Details
    In: Infection and Immunity, American Society for Microbiology, Vol. 67, No. 2 ( 1999-02), p. 469-477
    Abstract: The mannose receptor (MR) is involved in the phagocytosis of pathogenic microorganisms. Here we investigated its role in the bactericidal functions of human monocyte-derived macrophages (MDMs), using (i) trimannoside-bovine serum albumin (BSA)-coated latex beads and zymosan as particulate ligands of the MR, and (ii) mannan and mannose-BSA as soluble ligands. We show that phagocytosis of mannosylated latex beads did not elicit the production of O 2 − . Zymosan, which is composed of α-mannan and β-glucan, was internalized by the MR and a β-glucan receptor, but the production of O 2 − was triggered only by phagocytosis through the β-glucan receptor. Activation and translocation of Hck, a Src family tyrosine kinase located on lysosomes, has previously been used as a marker of fusion between lysosomes and phagosomes in human neutrophils. In MDMs, Hck was activated and recruited to phagosomes containing zymosan later than LAMP-1 and CD63. Phagosomes containing mannosylated latex beads fused with LAMP-1 and CD63 vesicles but not with the Hck compartment, and the kinase was not activated. We also demonstrate that the MR was unable to distinguish between nonpathogenic and pathogenic mycobacteria, as they were internalized at similar rates by this receptor, indicating that this route of entry cannot be considered as a differential determinant of the intracellular fate of mycobacteria. In conclusion, MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms.
    Type of Medium: Online Resource
    ISSN: 0019-9567 , 1098-5522
    URL: Article
    DOI: 10.1128/IAI.67.2.469-477.1999
    RVK:
    XA 10000
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1999
    detail.hit.zdb_id: 1483247-1
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