In:
Antioxidants, MDPI AG, Vol. 11, No. 9 ( 2022-09-18), p. 1836-
Abstract:
Trehalose, spermidine, nicotinamide, and polyphenols have been shown to display pro-autophagic and antioxidant properties, eventually reducing cardiovascular and ischemic complications. This study aimed to investigate whether a mixture of these components improves maximal walking distance (MWD) in peripheral artery disease (PAD) patients. Nitrite/nitrate (NOx), endothelin-1, sNOX2-dp, H2O2 production, H2O2 break-down activity (HBA), ATG5 and P62 levels, flow-mediated dilation (FMD), and MWD were evaluated in 20 PAD patients randomly allocated to 10.5 g of mixture or no-treatment in a single-blind study. The above variables were assessed at baseline and 60 days after mixture ingestion. Compared with baseline, mixture intake significantly increased MWD (+91%; p 〈 0.01) and serum NOx (+96%; p 〈 0.001), whereas it significantly reduced endothelin-1 levels (−30%, p 〈 0.01). Moreover, mixture intake led to a remarkable reduction in sNOX2dp (−31%, p 〈 0.05) and H2O2 (−40%, p 〈 0.001) and potentiated antioxidant power (+110%, p 〈 0.001). Finally, mixture ingestion restored autophagy by increasing ATG5 (+43%, p 〈 0.01) and decreasing P62 (−29%, p 〈 0.05). No changes in the above-mentioned variables were observed in the no-treatment group. The treatment with a mixture of trehalose, spermidine, nicotinamide, and polyphenols improves MWD in PAD patients, with a mechanism possibly related to NOX2-mediated oxidative stress downregulation and autophagic flux upregulation. Clinical Trial Registration unique identifier: NCT04061070.
Type of Medium:
Online Resource
ISSN:
2076-3921
DOI:
10.3390/antiox11091836
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2704216-9
SSG:
15,3
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