In:
ChemistrySelect, Wiley, Vol. 3, No. 6 ( 2018-02-14), p. 1719-1726
Abstract:
Synthesis, characterization and biological activities of a silver(I) complex with cycloserine (AgCIC) are presented. Elemental, thermal and mass spectrometric analyses permitted proposing the minimal formula AgC 3 H 5 N 2 O 2 . The structure of the AgCIC complex was solved by powder X‐ray diffraction (XRD) studies. Coordination of the ligand to silver was shown to occur by the nitrogen atom of the heterocyclic ring and by the nitrogen and oxygen atoms of the amino and carbonyl groups, leading to a polymeric arrangement. Infrared (IR) and nuclear magnetic resonance (NMR) spectroscopic analyses confirmed the coordination sites. Antibacterial assays revealed the activity of the AgCIC complex against Mycobacterium tuberculosis , with minimal inhibitory concentration (MIC 90 ) of 79.1 μmol⋅L −1 , and against Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa bacterial strains. Antiproliferative assays over a panel of tumoral and non‐tumoral cells showed that the AgCIC complex is more active and selective than doxorubicin against breast and leukemia cancer cells, considering the total growth inhibition (TGI) values. The interaction of the complex with biomolecules and its mutagenicity were also investigated.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.201703078
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2844262-3
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