In:
Nature Communications, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2015-09-22)
Abstract:
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects ( n =2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort ( n =3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC ( P combined 〈 5 × 10 −8 ) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.
Type of Medium:
Online Resource
ISSN:
2041-1723
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2015
detail.hit.zdb_id:
2553671-0
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