In:
Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-05-24)
Abstract:
Follicular helper T (T FH ) cells control antibody responses by supporting antibody affinity maturation and memory formation. Inadequate T FH function has been found in individuals with ineffective responses to vaccines, but the mechanism underlying T FH regulation in vaccination is not understood. Here, we report that lower serum levels of the metabolic hormone leptin associate with reduced vaccine responses to influenza or hepatitis B virus vaccines in healthy populations. Leptin promotes mouse and human T FH differentiation and IL-21 production via STAT3 and mTOR pathways. Leptin receptor deficiency impairs T FH generation and antibody responses in immunisation and infection. Similarly, leptin deficiency induced by fasting reduces influenza vaccination-mediated protection for the subsequent infection challenge, which is mostly rescued by leptin replacement. Our results identify leptin as a regulator of T FH cell differentiation and function and indicate low levels of leptin as a risk factor for vaccine failure.
Type of Medium:
Online Resource
ISSN:
2041-1723
DOI:
10.1038/s41467-021-23220-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2553671-0
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