In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 19, No. 9 ( 2023-9-14), p. e1010910-
Abstract:
Blood group O is associated with protection against severe malaria and reduced size and stability of P . falciparum- host red blood cell (RBC) rosettes compared to non-O blood groups. Whether the non-O blood groups encoded by the specific ABO genotypes AO , BO , AA , BB and AB differ in their associations with severe malaria and rosetting is unknown. The A and B antigens are host RBC receptors for rosetting, hence we hypothesized that the higher levels of A and/or B antigen on RBCs from AA , BB and AB genotypes compared to AO/BO genotypes could lead to larger rosettes, increased microvascular obstruction and higher risk of malaria pathology. We used a case-control study of Kenyan children and in vitro adhesion assays to test the hypothesis that “double dose” non- O genotypes ( AA , BB , AB ) are associated with increased risk of severe malaria and larger rosettes than “single dose” heterozygotes ( AO , BO ). In the case-control study, compared to OO , the double dose genotypes consistently had higher odds ratios (OR) for severe malaria than single dose genotypes, with AB (OR 1.93) and AO (OR 1.27) showing most marked difference ( p = 0.02, Wald test). In vitro experiments with blood group A-preferring P . falciparum parasites showed that significantly larger rosettes were formed with AA and AB host RBCs compared to OO , whereas AO and BO genotypes rosettes were indistinguishable from OO . Overall, the data show that ABO genotype influences P . falciparum rosetting and support the hypothesis that double dose non- O genotypes confer a greater risk of severe malaria than AO/BO heterozygosity.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1010910
DOI:
10.1371/journal.pgen.1010910.g001
DOI:
10.1371/journal.pgen.1010910.t001
DOI:
10.1371/journal.pgen.1010910.t002
DOI:
10.1371/journal.pgen.1010910.t003
DOI:
10.1371/journal.pgen.1010910.t004
DOI:
10.1371/journal.pgen.1010910.t005
DOI:
10.1371/journal.pgen.1010910.t006
DOI:
10.1371/journal.pgen.1010910.s001
DOI:
10.1371/journal.pgen.1010910.s002
DOI:
10.1371/journal.pgen.1010910.s003
DOI:
10.1371/journal.pgen.1010910.s004
DOI:
10.1371/journal.pgen.1010910.s005
DOI:
10.1371/journal.pgen.1010910.s006
DOI:
10.1371/journal.pgen.1010910.s007
DOI:
10.1371/journal.pgen.1010910.s008
DOI:
10.1371/journal.pgen.1010910.s009
DOI:
10.1371/journal.pgen.1010910.s010
DOI:
10.1371/journal.pgen.1010910.s011
DOI:
10.1371/journal.pgen.1010910.s012
DOI:
10.1371/journal.pgen.1010910.s013
DOI:
10.1371/journal.pgen.1010910.s014
DOI:
10.1371/journal.pgen.1010910.r001
DOI:
10.1371/journal.pgen.1010910.r002
DOI:
10.1371/journal.pgen.1010910.r003
DOI:
10.1371/journal.pgen.1010910.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2186725-2
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