In:
Frontiers in Molecular Neuroscience, Frontiers Media SA, Vol. 15 ( 2022-2-10)
Abstract:
The neuroprotective effect of electroacupuncture (EA) treatment has been well studied; growing evidence suggests that changes in lipid composition may be involved in the pathogenesis of post-traumatic stress disorder (PTSD) and may be a target for treatment. However, the influence of early EA intervention on brain lipid composition in patients with PTSD has never been investigated. Using a modified single prolonged stress (mSPS) model in mice, we assessed the anti-PTSD-like effects of early intervention using EA and evaluated changes in lipid composition in the hippocampus and prefrontal cortex (PFC) using a mass spectrometry-based lipidomic approach. mSPS induced changes in lipid composition in the hippocampus, notably in the content of sphingolipids, glycerolipids, and fatty acyls. These lipid changes were more robust than those observed in the PFC. Early intervention with EA after mSPS ameliorated PTSD-like behaviors and partly normalized mSPS-induced lipid changes, notably in the hippocampus. Cumulatively, our data suggest that EA may reverse mSPS-induced PTSD-like behaviors due to region-specific regulation of the brain lipidome, providing new insights into the therapeutic mechanism of EA.
Type of Medium:
Online Resource
ISSN:
1662-5099
DOI:
10.3389/fnmol.2022.812479
DOI:
10.3389/fnmol.2022.812479.s001
DOI:
10.3389/fnmol.2022.812479.s002
DOI:
10.3389/fnmol.2022.812479.s003
DOI:
10.3389/fnmol.2022.812479.s004
DOI:
10.3389/fnmol.2022.812479.s005
DOI:
10.3389/fnmol.2022.812479.s006
DOI:
10.3389/fnmol.2022.812479.s007
DOI:
10.3389/fnmol.2022.812479.s008
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2452967-9
Permalink