In:
Cerebral Cortex, Oxford University Press (OUP), Vol. 33, No. 15 ( 2023-07-24), p. 9409-9416
Kurzfassung:
Obesity may lead to cognitive impairment and psychiatric disorders, which are associated with alterations in the brain cortical structure. However, the exact causality remains inconclusive. We aimed to conduct two-sample Mendelian randomization (MR) analysis to identify the causal associations of obesity [body mass index (BMI), waist-hip ratio (WHR), and waist-hip ratio adjusted for BMI ((WHRadjBMI)) and brain cortical structure (cortical thickness and cortical surface area). Inverse-variance weighted (IVW) method was used as the main analysis, whereas a series of sensitivity analyses were employed to assess heterogeneity and pleiotropy. The main MR results showed that higher BMI significantly increased the cortical surface area of the transverse temporal (β = 5.13 mm2, 95% confidence interval [CI]: 2.55–7.71, P = 9.9 × 10−5); higher WHR significantly decreased cortical surface area of the inferior temporal (β = −38.60, 95% CI: −56.67- -20.54, P = 1.2 × 10−5), but significantly increased cortical surface area of the isthmus cingulate (β = 14.25, 95% CI: 6.97–21.54, P = 1.2 × 10–4). No significant evidence of pleiotropy was found in the MR analyses. This study supports that obesity has a causal effect on the brain cortical structure. Further studies are warranted to understand the clinical outcomes caused by these effects.
Materialart:
Online-Ressource
ISSN:
1047-3211
,
1460-2199
DOI:
10.1093/cercor/bhad214
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2023
ZDB Id:
1483485-6
SSG:
12
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