In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 8 ( 2023-8-25), p. e0285227-
Abstract:
Established assessment tools for patients with rheumatoid arthritis (RA), including disease activity scores (DASs), disease activity indexes (DAIs), visual analog scales (VASs), and health assessment questionnaires (HAQs), are widely used. However, comparative associations between joint involvement and disease status assessment tools have rarely been investigated. Methods We included a dataset of 4016 patients from a large RA cohort from 2012 to 2019. The tenderness and swelling of each joint were counted as a symptom, with 70 and 68 affected joints throughout the body, respectively. The relative contribution of various joints to the disease status assessment tools, VAS scores, and functional disability indexes was analyzed using multiple regression analysis. Results The wrist showed the most significant contribution overall, especially in DASs and VASs, while the metacarpophalangeal and proximal interphalangeal joints made significant contributions to DASs and DAIs, but not to VASs and HAQs. The shoulder and the elbow significantly contributed to HAQs, but only the shoulder did to the VASs. The knee universally contributed to all of the tools, but the ankle played a minor but important role in most assessment tools, especially in HAQs. Similar but different contribution ratios were found between the sets of DASs, DAIs, VASs, or HAQs. Conclusions Each joint makes a unique contribution to these assessment tools. The improvement or aggravation of symptoms in each joint affects the assessment tools in different manners.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0285227
DOI:
10.1371/journal.pone.0285227.g001
DOI:
10.1371/journal.pone.0285227.g002
DOI:
10.1371/journal.pone.0285227.g003
DOI:
10.1371/journal.pone.0285227.g004
DOI:
10.1371/journal.pone.0285227.t001
DOI:
10.1371/journal.pone.0285227.t002
DOI:
10.1371/journal.pone.0285227.t003
DOI:
10.1371/journal.pone.0285227.s001
DOI:
10.1371/journal.pone.0285227.s002
DOI:
10.1371/journal.pone.0285227.s003
DOI:
10.1371/journal.pone.0285227.s004
DOI:
10.1371/journal.pone.0285227.s005
DOI:
10.1371/journal.pone.0285227.s006
DOI:
10.1371/journal.pone.0285227.s007
DOI:
10.1371/journal.pone.0285227.s008
DOI:
10.1371/journal.pone.0285227.s009
DOI:
10.1371/journal.pone.0285227.s010
DOI:
10.1371/journal.pone.0285227.s011
DOI:
10.1371/journal.pone.0285227.s012
DOI:
10.1371/journal.pone.0285227.s013
DOI:
10.1371/journal.pone.0285227.s014
DOI:
10.1371/journal.pone.0285227.r001
DOI:
10.1371/journal.pone.0285227.r002
DOI:
10.1371/journal.pone.0285227.r003
DOI:
10.1371/journal.pone.0285227.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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