In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 26, No. 22 ( 2012-11-15), p. 2477-2482
Abstract:
Transcription elongation is stimulated by positive transcription elongation factor b (P-TEFb), for which activity is repressed in the 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. We show here a critical role of 7SK snRNP in growth control of primordial germ cells (PGCs). The expression of p15 INK4b , a cyclin-dependent kinase inhibitor (CDKI) gene, in PGCs is selectively activated by P-TEFb and its recruiting molecule, Brd4, when the amount of active P-TEFb is increased due to reduction of the 7SK snRNP, and PGCs consequently undergo growth arrest. These results indicate that CDKI gene-specific control of transcription by 7SK snRNP plays a pivotal role in the maintenance of PGC proliferation.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
DOI:
10.1101/gad.202242.112
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2012
detail.hit.zdb_id:
1467414-2
SSG:
12
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