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  • 1
    Online Resource
    Online Resource
    Rationale, design, and baseline characteristics of Chinese registry in early detection and risk stratification of coronary plaques (C-STRAT) study
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Chinese Medical Journal Vol. 134, No. 7 ( 2021-01-5), p. 870-872
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 134, No. 7 ( 2021-01-5), p. 870-872
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001307
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 2
    Online Resource
    Online Resource
    The Activities and Secretion of Cytokines Caused by Delamanid on Macrophages Infected by Multidrug-Resistant Mycobacterium tuberculosis Strains
    Frontiers Media SA ; 2021
    In:  Frontiers in Immunology Vol. 12 ( 2021-12-24)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-12-24)
    Abstract: Delamanid (Dlm) is an effective drug against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, including Multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). There are few reports on the activity and secretion of cytokines caused by Dlm on macrophages infected by MDR-MTB strains. Therefore, this article aims to observe the bactericidal activity and secretion of cytokines of the macrophages infected by MDR-MTB strains after Dlm was administered, so as to provide a basis for further perfecting the mechanism of Dlm. Methods Samples were respectively collected to count the intracellular colony-forming unit (CFU) of macrophages infected by MDR-MTB or H37Rv strains at 4, 8, 24, and 48 h after Dlm at MIC, 10MIC, and 20MIC were administered. Samples were respectively collected to detect the level of IL-12/23 p40, TNF-α, IL-6, and IL-10 in the culture supernatant of macrophages infected by MDR-MTB or H37Rv strains at 4, 24, and 48 h after Dlm at MIC were administered. The levels of four cytokines in the culture supernatant were measured using the Luminex ® 200™ (Luminex, USA) according to the manufacturer’s instructions. Data were analyzed by SPSS 25.0 software. The continuous data in normal distribution were expressed as mean ± standard deviation ( x ¯ ± s ) and analyzed by t or F test. P & lt;0.05 was considered statistically significant. Results (1) After Dlm was applied to macrophages infected by MDR-MTB strains: (A) The intracellular CFU gradually decreased, reached the lowest value at 48 h, and was lower than that of Dlm before administration and infection group ( P & lt;0.05). (B) The intracellular CFU was further reduced after increasing Dlm dose to 10MIC and 20MIC, and the latter was lower than that of the former ( P & lt;0.05). (C) The intracellular CFU of MDR-MTB group was higher than that of H37Rv group at 4~48 h after administration ( P & lt;0.05). (2) After Dlm at MIC dose was applied to macrophages infected by MDR-MTB strains: (A) The level of IL-12/23 p40 at any time didn’t change compared with that of Dlm before administration ( P & gt;0.05), while the level of IL-12/23 p40 at 4 h was higher than that of the infection group ( P & lt;0.05). The levels of TNF-α at 24 and 48 h were higher than that of Dlm before administration ( P & lt;0.05), but were similar to that of the infection group ( P & gt;0.05). In addition, the levels of IL-12/23 p40 and TNF-α at any time were similar to that of the H37Rv group after administration ( P & gt;0.05). (B) The levels of IL-6 at 24 and 48 h were higher than that of Dlm before administration ( P & lt;0.05), but were similar to that of H37Rv group ( P & gt;0.05) and were lower than that of infection group ( P & lt;0.05). The level of IL-10 at any time didn’t change compared with that of Dlm before administration ( P & gt;0.05), but was lower than that of the infection group at 4~48 h and was lower than that of the H37Rv group at 24 h ( P & lt;0.05). (C) The level of IL-12/23 p40 and IL-10 didn’t change with the change of intracellular CFU ( P & lt;0.05), while the level of TNF-α and IL-6 increased with the intracellular CFU decreasing, and the increase level of TNF-α was lower than that of the infection group ( P & lt;0.05). Conclusions Dlm had strong bactericidal activity against intracellular MDR-MTB, which was time-dependent and concentration-dependent. Its bactericidal activity against intracellular MDR-MTB strains was weaker than that against drug-susceptible tuberculosis strains. Dlm might have immunomodulatory effect, inducing low expression of Th2 cytokines IL-6 and IL-10 at different times after administration.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    DOI: 10.3389/fimmu.2021.796677
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 3
    Online Resource
    Online Resource
    Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains
    Hindawi Limited ; 2022
    In:  Canadian Journal of Infectious Diseases and Medical Microbiology Vol. 2022 ( 2022-4-11), p. 1-9
    Details
    In: Canadian Journal of Infectious Diseases and Medical Microbiology, Hindawi Limited, Vol. 2022 ( 2022-4-11), p. 1-9
    Abstract: Background. Bedaquiline (Bdq) exerts bactericidal effects against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, including multidrug-resistant M. tuberculosis strains (MDR-MTBs). However, few reported investigations exist regarding Bdq effects on MDR-MTBs-infected macrophages activities and cytokine secretion. Here, Bdq bactericidal activities against MDR-MTBs and related cellular immune mechanisms were explored. Methods. Macrophages infected with MDR-MTBs or H37Rv received Bdq treatments (4 h/8 h/24 h/48 h) at 1 × the minimum inhibitory concentration (1 × MIC), 10 × MIC and 20 × MIC. Intracellular colony-forming units (CFUs) and culture supernatant IL-12/23 p40, TNF-α, IL-6, and IL-10 were determined using the Luminex® 200TM system. Normally distributed continuous data (mean ± standard deviation) were analyzed using t-test or F-test (SPSS 25.0, P 〈 0.05 deemed statistically significant). Results. (1) 100% of Bdq-treated macrophages (all doses applied over 4–48 h) survived with 0% inhibition of proliferation observed. (2) Intracellular CFUs of Bdq-treated MDR-MTBs-infected macrophages decreased over 4–48 h of treatment, were lower than preadministration and control CFUs, decreased with increasing Bdq dose, and resembled H37Rv-infected group CFUs (48 h). (3) For MDR-MTBs-infected macrophages (various Bdq doses), IL-12/23 p40 levels resembled preadministration group levels and exceeded controls (4 h); TNF-α levels exceeded preadministration group levels (24 h/48 h) and controls (24 h); IL-12/23 p40 and TNF-α levels resembled H37Rv-infected group levels (4 h/8 h/24 h/48 h); IL-6 levels exceeded preadministration and H37Rv-infected group levels (24 h/48 h) and controls (24 h); IL-10 levels resembled preadministration and H37Rv-infected group levels (4 h/8 h/24 h/48 h) and were lower than controls (24 h/48 h); IL-12/23 p40 and IL-10 levels remained unchanged as intracellular CFUs changed, with IL-12/23 p40 levels exceeding controls (4 h) and IL-10 levels remaining lower than controls (24 h/48 h); TNF-α and IL-6 levels increased as intracellular CFUs decreased (24 h/48 h) and exceed controls (24 h). Conclusion. Bdq was strongly bactericidal against intracellular MDR-MTBs and H37Rv in a time-dependent, concentration-dependent manner. Bdq potentially exerted immunomodulatory effects by inducing high-level Th1 cytokine expression (IL-12/23 p40, TNF-α) and low-level Th2 cytokine expression (IL-10).
    Type of Medium: Online Resource
    ISSN: 1918-1493 , 1712-9532
    URL: Article
    DOI: 10.1155/2022/2703635
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2207109-X
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  • 4
    Online Resource
    Online Resource
    Advances in the clinical application of ultrasound elastography in uterine imaging
    Springer Science and Business Media LLC ; 2022
    In:  Insights into Imaging Vol. 13, No. 1 ( 2022-09-04)
    Details
    In: Insights into Imaging, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-09-04)
    Abstract: Changes in tissue stiffness by physiological or pathological factors in tissue structure are identified earlier than their clinical features. Pathological processes such as uterine fibrosis, adenomyosis, endometrial lesions, infertility, and premature birth can manifest as tissue elasticity changes. In clinical settings, elastography techniques based on ultrasonography, optical coherence tomography, and magnetic resonance imaging are widely used for noninvasive measurement of mechanical properties in patients, providing valuable tool and information for diagnosis and treatment. Ultrasound elastography (USE) plays a critical role in obstetrics and gynecology clinical work because of its simplicity, non-invasiveness, and repeatability. This article reviews the recent progress of USE in uterine tumor diagnosis (especially early diagnosis and treatment effect evaluation), prediction of preterm birth, and intrauterine insemination. We believe that USE, especially shear wave elastography, may serve as a potential means to assess tissue stiffness, thereby improving the diagnosis and treatment of adenomyosis, fibroids, endometrial lesions, cervical cancer, and precise management of preterm birth and intrauterine insemination monitoring.
    Type of Medium: Online Resource
    ISSN: 1869-4101
    URL: Article
    DOI: 10.1186/s13244-022-01274-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2543323-4
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  • 5
    Online Resource
    Online Resource
    Different subtypes of ultrasound‐diagnosed adenomyosis and in vitro fertilization outcomes: A systematic review and meta‐analysis
    Wiley ; 2023
    In:  Acta Obstetricia et Gynecologica Scandinavica Vol. 102, No. 6 ( 2023-06), p. 657-668
    Details
    In: Acta Obstetricia et Gynecologica Scandinavica, Wiley, Vol. 102, No. 6 ( 2023-06), p. 657-668
    Abstract: Adenomyosis prevalence among women with infertility is increasing; their management during in vitro fertilization is usually based on ultrasound diagnosis alone. Herein, we summarize the latest evidence on the impact of ultrasound‐diagnosed adenomyosis on in vitro fertilization outcomes. Material and methods The study was registered with The International Prospective Register of Systematic Reviews (CRD42022355584). We searched PubMed, Embase, and Cochrane Library databases from inception to January 31, 2023, for cohort studies on the impact of adenomyosis on in vitro fertilization outcomes. Fertility outcomes were compared according to the presence of adenomyosis as diagnosed by ultrasound, concurrent endometriosis and adenomyosis, and MRI‐based or MRI‐ and ultrasound‐based adenomyosis diagnosis. Live birth rate was the primary outcome while clinical pregnancy and miscarriage rates were secondary outcomes. Results Women diagnosed with adenomyosis by ultrasound had lower live birth (odds ratio [OR] = 0.66; 95% confidence interval [CI] : 0.53–0.82, grade: very low), lower clinical pregnancy (OR = 0.64; 95% CI: 0.53–0.77, grade: very low), and higher miscarriage (OR = 1.81; 95% CI: 1.35–2.44, grade: very low) rates than those without adenomyosis. Notably, symptomatic and diffuse, but not asymptomatic adenomyosis as diagnosed by ultrasound, adversely affected in vitro fertilization outcomes, with lower live birth (OR = 0.57; 95% CI: 0.34–0.96, grade: very low), clinical pregnancy (OR = 0.69; 95% CI: 0.57–0.85, grade: low), and miscarriage (OR = 2.48, 95% CI: 1.28–4.82, grade: low) rates; and lower live birth (OR = 0.37; 95% CI: 0.23–0.59, grade: low) and clinical pregnancy (OR = 0.50; 95% CI: 0.34–0.75, grade: low), but not miscarriage rate (OR = 2.18; 95% CI: 0.72–6.62, grade: very low), respectively. Concurrent adenomyosis in endometriosis is associated with a significantly lower live birth rate (OR = 0.44; 95% CI: 0.26–0.75, grade: low) than endometriosis alone. Finally, the use of MRI‐based or MRI‐ and ultrasound‐based adenomyosis diagnosis showed no significant association with in vitro fertilization outcomes (grade: very low for all outcomes). Conclusions Considering ultrasound findings, symptoms, and different subtypes of adenomyosis may aid in offering personalized counseling, improving treatment decisions, and achieving better outcomes of in vitro fertilization.
    Type of Medium: Online Resource
    ISSN: 0001-6349 , 1600-0412
    URL: Issue
    URL: Article
    DOI: 10.1111/aogs.v102.6
    DOI: 10.1111/aogs.14580
    RVK:
    YM 6500
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2024554-3
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  • 6
    Online Resource
    Online Resource
    Near-infrared Fluorescent Probe Based on Methylene Blue for Specific Detection of Hypochlorous Acid
    Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences ; 2020
    In:  fgxb Vol. 41, No. 7 ( 2020), p. 791-799
    Details
    In: fgxb, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Vol. 41, No. 7 ( 2020), p. 791-799
    Type of Medium: Online Resource
    ISSN: 1000-7032
    URL: Article
    DOI: 10.37188/fgxb20204107.0791
    Language: English
    Publisher: Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences
    Publication Date: 2020
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  • 7
    Online Resource
    Online Resource
    Particulate matter of 2.5 μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1α in an asthma model
    Elsevier BV ; 2020
    In:  Journal of Allergy and Clinical Immunology Vol. 145, No. 1 ( 2020-01), p. 402-414
    Details
    In: Journal of Allergy and Clinical Immunology, Elsevier BV, Vol. 145, No. 1 ( 2020-01), p. 402-414
    Type of Medium: Online Resource
    ISSN: 0091-6749
    URL: Article
    DOI: 10.1016/j.jaci.2019.10.008
    RVK:
    XA 52000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2006613-2
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  • 8
    Online Resource
    Online Resource
    Diagnostic Performance of Doppler Ultrasonography for the Detection of Fetal Anemia : A Meta-analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Ultrasound Quarterly Vol. 35, No. 4 ( 2019-12), p. 339-345
    Details
    In: Ultrasound Quarterly, Ovid Technologies (Wolters Kluwer Health), Vol. 35, No. 4 ( 2019-12), p. 339-345
    Abstract: This study evaluates the diagnostic performance of Doppler ultrasound in diagnosing fetal anemia. Data were taken from relevant study reports published in peer-reviewed journals identified after a literature search in electronic databases. Random effects meta-analyses were performed by pooling the effect sizes of diagnostic indices (sensitivity, specificity, positive/negative predictive values, and false-positive rate) or correlation coefficients reported by individual studies. As a result, 31 studies (1848 pregnancies; gestation age, 28.25 weeks [95% confidence interval {CI}, 26.87–29.63]) were included in the meta-analysis. Anemia was found in 63.7% (95% CI, 49.7–77.7) fetuses, and severe anemia was found in 36.7% (95% CI, 26.9–46.4) fetuses. Sensitivity and specificity of Doppler ultrasound for detecting fetal anemia in alloimmunized fetuses at middle cerebral artery peak systolic velocity cutoff of 1.5 multiple of median for gestation age were 83.42% (95% CI, 71.75–95.09) and 80.30% (95% CI, 73.58–87.02), respectively. Positive predictive value, negative predictive value, and false-positive rate were 76.35% (95% CI, 65.98–86.72), 80.0% (95% CI, 76.63–83.37), and 10.4% (95% CI, 5.9–14.9), respectively. Correlation coefficient between hematological anemia and Doppler ultrasound–measured blood flow velocity was −0.706 (95% CI, −0.765 to −0.635; P ˂ 0.00001). In conclusion, Doppler ultrasound–measured middle cerebral artery peak systolic velocity at 1.5 multiple of median provides good diagnostic strength for the detection of alloimmunized fetal anemia. A strong correlation between Doppler velocimetric measures and hematological anemia is also observed.
    Type of Medium: Online Resource
    ISSN: 1536-0253
    URL: Article
    DOI: 10.1097/RUQ.0000000000000450
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2060555-9
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  • 9
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    Combination of inclusive top-quark pair production cross-section measurements using ATLAS and CMS data at $$ \sqrt{s} $$ = 7 and 8 TeV
    Springer Science and Business Media LLC ; 2023
    In:  Journal of High Energy Physics Vol. 2023, No. 7 ( 2023-07-27)
    Details
    In: Journal of High Energy Physics, Springer Science and Business Media LLC, Vol. 2023, No. 7 ( 2023-07-27)
    Abstract: A combination of measurements of the inclusive top-quark pair production cross-section performed by ATLAS and CMS in proton–proton collisions at centre-of-mass energies of 7 and 8 TeV at the LHC is presented. The cross-sections are obtained using top-quark pair decays with an opposite-charge electron–muon pair in the final state and with data corresponding to an integrated luminosity of about 5 fb − 1 at $$ \sqrt{s} $$ s = 7 TeV and about 20 fb − 1 at $$ \sqrt{s} $$ s = 8 TeV for each experiment. The combined cross-sections are determined to be 178 . 5 ± 4 . 7 pb at $$ \sqrt{s} $$ s = 7 TeV and $$ {243.3}_{-5.9}^{+6.0} $$ 243.3 − 5.9 + 6.0 pb at $$ \sqrt{s} $$ s = 8 TeV with a correlation of 0.41, using a reference top-quark mass value of 172.5 GeV. The ratio of the combined cross-sections is determined to be R 8 / 7 = 1 . 363 ± 0 . 032. The combined measured cross-sections and their ratio agree well with theory calculations using several parton distribution function (PDF) sets. The values of the top-quark pole mass (with the strong coupling fixed at 0.118) and the strong coupling (with the top-quark pole mass fixed at 172.5 GeV) are extracted from the combined results by fitting a next-to-next-to-leading-order plus next-to-next-to-leading-log QCD prediction to the measurements. Using a version of the NNPDF3.1 PDF set containing no top-quark measurements, the results obtained are $$ {m}_t^{\textrm{pole}}={173.4}_{-2.0}^{+1.8} $$ m t pole = 173.4 − 2.0 + 1.8 GeV and $$ {\alpha}_{\textrm{s}}\left({m}_Z\right)={0.1170}_{-0.0018}^{+0.0021} $$ α s m Z = 0.1170 − 0.0018 + 0.0021 .
    Type of Medium: Online Resource
    ISSN: 1029-8479
    URL: Article
    DOI: 10.1007/JHEP07(2023)213
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2027350-2
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  • 10
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    Observation of ψ ( 3686 ) → p p ¯ η ′ and improved measurement of J / ψ → p p ¯ η ′
    American Physical Society (APS) ; 2019
    In:  Physical Review D Vol. 99, No. 3 ( 2019-2-15)
    Details
    In: Physical Review D, American Physical Society (APS), Vol. 99, No. 3 ( 2019-2-15)
    Type of Medium: Online Resource
    ISSN: 2470-0010 , 2470-0029
    URL: Article
    DOI: 10.1103/PhysRevD.99.032006
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2019
    detail.hit.zdb_id: 2844732-3
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