In:
Ministry of Science and Technology, Vietnam, Ministry of Science and Technology, Vietnam (VMOST), Vol. 64, No. 3 ( 2022-9-15), p. 53-61
Abstract:
Hydrogel materials have attracted extensive research over the last few decades, especially in tissue engineering, due its many comparable properties with native tissue. This study proposes a new approach to hydrogel fabrication that combines oxidized alginate (OA) into N,O-carboxymethyl chitosan (NOCC) and an oxidized hyaluronan-based hydrogel system employing low cost, domestically sourced chitosan and alginate. Hydrogel fabrication parameters including component ratio and hydrogel concentration were studied. Fourier transform infrared spectroscopy (FT-IR) analysis was applied to confirm the chemical structure of the modified materials. Fabricated hydrogel samples were assessed by cross-sectional surface morphology, equilibrium swelling degree, and in vitro degradation behaviour. The results revealed NOCC and oxidized hyaluronic acid (OHA)-OA component contributions toward hydrogel properties, a threshold of raising total polymer content within the network, and a comparison with previous formulations using unmodified alginate. Using low cost domestic resources is a promising way to reduce fabrication expenses, and further work should be performed to evaluate the potential of this cost-effective hydrogel for the tissue engineering field.
Type of Medium:
Online Resource
ISSN:
2525-2461
DOI:
10.31276/VJSTE.64(3)
DOI:
10.31276/VJSTE.vol(number).page
DOI:
10.31276/VJSTE.64(3).53-61
Language:
Unknown
Publisher:
Ministry of Science and Technology, Vietnam (VMOST)
Publication Date:
2022
detail.hit.zdb_id:
3145662-5
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