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  • 1
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    Online Resource
    Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection
    Journal of Infection in Developing Countries ; 2020
    In:  The Journal of Infection in Developing Countries Vol. 14, No. 05 ( 2020-05-31), p. 519-526
    Details
    In: The Journal of Infection in Developing Countries, Journal of Infection in Developing Countries, Vol. 14, No. 05 ( 2020-05-31), p. 519-526
    Abstract: Introduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and blood products, nosocomial transmission of HCV, and prolong hemodialysis duration. The aim of the study was to evaluate the influence of IL-33/ST2 signaling pathway on severity of the liver disease in ESRD HCV+ patients. Methodology: Blood samples from patients with end stage renal disease (ESRD) and hepatitis C infection (HCV), 20 patients with HCV infection, 20 patients with ESRD and 20 healthy control donor patients were taken for the examination of biochemical parameters, for the determination of the serum cytokine concentration, and for the molecular diagnostics of HCV. Results: Systemic sST2 positively correlated with serum level of urea and creatinine, respectively. Serum sST2 was significantly increased in ESRD HCV+ patients in comparison to HCV+ group. sST2/IL-1, sST2/IL-4 and sST2/IL-23 ratios were significantly increased in serum of ESRD HCV+ patients in comparison to HCV+ patients. Significantly higher systemic level of sST2 and sST2/IL-1 and sST2/IL-4 ratios were measured in ESRD patients compared to non-ESRD patients. Conclusion: These results suggested that elevated level sST2, as the consequence of renal failure, causes less destruction of liver in HCV infection.
    Type of Medium: Online Resource
    ISSN: 1972-2680
    URL: Article
    DOI: 10.3855/jidc.11741
    Language: Unknown
    Publisher: Journal of Infection in Developing Countries
    Publication Date: 2020
    detail.hit.zdb_id: 2394024-4
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  • 2
    Online Resource
    Online Resource
    Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients
    Hindawi Limited ; 2017
    In:  Disease Markers Vol. 2017 ( 2017), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: Hepatitis C virus infection (HCV), one of the greatest causes of liver disease, is a frequent complication in patients with end-stage renal disease (ESRD) on dialysis. ESRD is defined as decreased glomerular filtration and also accompanied by impaired function of the immune system. Galectin-3 is a β -galactoside-binding lectin, involved in various biological processes including pathogenesis of chronic renal disease. The aim of our study was to estimate disease severity in ESRD HCV + patients and analyze the serum concentrations of IL-1 β , IL-4, IL-23, and IL-6; anti-HCV antibodies; and galectin-3. Also, we attempted to determine potential correlation between galectin-3 level and parameters of disease severity ALT and AST. Our results showed decreased levels of ALT and AST ( p = 0.00 ), demonstrating less liver destruction in ESRD HCV + patients in comparison to HCV + patients. Increased levels of IL-6 ( p = 0.03 ) implicate a hepatoprotective role of IL-6 in these patients. Also, level of galectin-3 ( p = 0.00 ) in the serum of ESRD HCV + patients was higher than that of HCV + patients. This alteration was accompanied with negative correlation between galectin-3 and AST and ALT, respectively ( p = 0.029 ; p = 0.033 ). The presence of increased systemic levels of IL-6 and Gal-3 in ESRD HCV + patients may be an attempt to counteract or limit ongoing proinflammatory processes and to downregulate chronic inflammation, suggesting the new aspects of HCV infection in ESRD patients.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2017/6275987
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2033253-1
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  • 3
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    Online Resource
    Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs
    Walter de Gruyter GmbH ; 2021
    In:  Open Chemistry Vol. 19, No. 1 ( 2021-02-05), p. 60-106
    Details
    In: Open Chemistry, Walter de Gruyter GmbH, Vol. 19, No. 1 ( 2021-02-05), p. 60-106
    Abstract: The misuse of psychoactive substances is attracting a great deal of attention from the general public. An increase use of psychoactive substances is observed among young people who do not have enough awareness of the harmful effects of these substances. Easy access to illicit drugs at low cost and lack of effective means of routine screening for new psychoactive substances (NPS) have contributed to the rapid increase in their use. New research and evidence suggest that drug use can cause a variety of adverse psychological and physiological effects on human health (anxiety, panic, paranoia, psychosis, and seizures). We describe different classes of these NPS drugs with emphasis on the methods used to identify them and the identification of their metabolites in biological specimens. This is the first review that thoroughly gives the literature on both natural and synthetic illegal drugs with old known data and very hot new topics and investigations, which enables the researcher to use it as a starting point in the literature exploration and planning of the own research. For the first time, the conformational analysis was done for selected illegal drugs, giving rise to the search of the biologically active conformations both theoretically and using lab experiments.
    Type of Medium: Online Resource
    ISSN: 2391-5420
    URL: Article
    DOI: 10.1515/chem-2021-0196
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2825411-9
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  • 4
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    Online Resource
    Mechanisms of Intracellular Chlamydiae Survival
    Walter de Gruyter GmbH ; 2016
    In:  Serbian Journal of Experimental and Clinical Research Vol. 17, No. 2 ( 2016-6-1), p. 145-152
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 17, No. 2 ( 2016-6-1), p. 145-152
    Abstract: Chlamydiae are Gram-negative, non-motile, obligate intracellular, and spherically shaped bacteria with a diameter of 0.2-1.5 μm. Chlamydiae are present in several different morphological forms: the elementary body, the reticular body, and in the last several years, there has been the observation of a third form known as the persistent or atypical form. The intracellular localization of Chlamydia provides a unique replication cycle that occurs inside a membrane-surrounded vacuole in the host cell cytoplasm and is significantly different from the method of multiplication of other microorganisms. Chlamydiae are capable of manipulating different signalling pathways inside the infected cell, thus avoiding the host immune response. This ensures intracellular multiplication, survival, and long-term persistence of Chlamydiae. There are two basic means of achieving this persistence: inhibition of apoptosis and manipulation of NF-κB (nuclear factor kappa B)-mediated signals in the host.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.1515/sjecr-2016-0010
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2710266-X
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  • 5
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    Online Resource
    HCV Infection and Chronic Renal Disease
    Walter de Gruyter GmbH ; 2021
    In:  Serbian Journal of Experimental and Clinical Research Vol. 0, No. 0 ( 2021-05-26)
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2021-05-26)
    Abstract: Chronic Hepatitis C virus (HCV) infection is defined as persistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver disease and cirrhosis. It’s serious public health problem, affects about 71 million people worldwide. HCV doesn’t destroy hepatocytes directly. It activates the host's innate and acquired immune system and causes liver injury indirectly. Behind hepatic, HCV can cause extra-hepatic manifestations. One of them is renal disease which can lead to end-stage renal disease, ESRD. The prevalence of HCV infection in patients on hemodialysis is high, ranging from 5% to 60%. HCV infection is a significant cause of morbidity and mortality in patients with ESRD on hemodialysis. In this review, we discuss HCV infection and chronic renal disease as comorbidities, their severity and outcome.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.2478/sjecr-2021-0010
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2710266-X
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  • 6
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    Online Resource
    The Quality of Life of Patients with Colorectal Carcinoma and Stoma
    Walter de Gruyter GmbH ; 2022
    In:  Serbian Journal of Experimental and Clinical Research Vol. 0, No. 0 ( 2022-10-14)
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2022-10-14)
    Abstract: Surgical treatment and formation of a stoma can be lifesaving for colorectal cancer patients. However, the quality of life is often impaired in patients with stoma. The goal of this study is to determine the quality of life of patients with stoma and cancer, and the relationship between the quality of life and characteristics of these patients. The study was conducted from 2018 to 2020 and included a total of 64 patients of both sexes with colorectal cancer and temporary or permanent stoma. The European Organization for Research and Treatment of Cancer with Quality of Life Questionnaire (EORTC QLQC29-30) and the anonymous WHO Quality of Life Questionnaire SF-36 were used for self-assessment of quality of life. Our study included 39 (61.0%) men and 25 (39.0%) women. 24 patients (37.5%) had colostomy, 14 patients (21.9%) had ileostomy, and 26 patients (40.6%) underwent surgery for resection of colorectal cancer without stoma. A significant number of women were in the group of patients with a permanent stoma (p = 0.01). There was no statistically significant difference in the assessment of general health (p = 0.680) and quality of life (p = 0.721) during the past month in relation to gender. Patients without a stoma rated their general health better compared to those with stoma and the difference reached statistical significance (p = 0.035). There was no statistically significant difference in the assessment of quality of life between the group of patients with stoma and without stoma, as well as between the patients of different age groups. Patients with stoma rated their general health as worse, but not their quality of life.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.2478/sjecr-2022-0039
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2022
    detail.hit.zdb_id: 2710266-X
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  • 7
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    Online Resource
    Periodontal Disease: Correlation with Histological and Immunological Parameters
    Walter de Gruyter GmbH ; 2023
    In:  Experimental and Applied Biomedical Research (EABR) Vol. 24, No. 1 ( 2023-03-01), p. 57-62
    Details
    In: Experimental and Applied Biomedical Research (EABR), Walter de Gruyter GmbH, Vol. 24, No. 1 ( 2023-03-01), p. 57-62
    Abstract: Periodontal disease is inflammatory pathological conditions in the gingiva and dental support structures that usually results in extracellular matrix and connective tissue destruction. During periodontitis, inflammatory cells facilitate collagen and connective tissue loss, affects the number and activity of fibroblasts and its production of local collagen networks. Aim of this study was to evaluate collagen density and accumulation of collagen producing fibroblast and macrophages in affected tissue of periodontal disease. Histological and immunohistochemical analyzes were performed on paraffin embedded tissue sections of gingival biopsies, obtained from 30 patients with diagnosis of periodontal disease and 10 healthy donors. Tissue sections of gingival of patients with periodontal disease had significantly decreased collagen volume density and visible fragmentation and lysis of the collagen fibers, decreased number of fibroblasts, accompanied with increased accumulation of macrophages. Presented data implicate that macrophages accumulation may be the cause of enzyme mediated collagen destruction
    Type of Medium: Online Resource
    ISSN: 2956-0454
    URL: Article
    DOI: 10.2478/sjecr-2020-0024
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
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  • 8
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    Online Resource
    Veridentification and determination of 2,5-dimetoxy-4-bromophenethylamine (2C-B) in real sample by GC-MS methods and derivatization after SPE preparation
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2022
    In:  Bulletin of Natural Sciences Research Vol. 12, No. 1 ( 2022), p. 1-4
    Details
    In: Bulletin of Natural Sciences Research, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 12, No. 1 ( 2022), p. 1-4
    Abstract: The abuse of new psychoactive substances is attracting a lot of attention from the world public. There is an increasing use among young people, who are not aware of the harmful effects of this substances. Some of these substances may have been around for years, but have reemerged in the market in altered chemical forms and launched as legal alternatives to common drugs of abuse. This paper describes application of gas chromatography coupled with mass spectrometry method (GC-MS) to identify 2,5-dimetoxy-4-bromophenethylamine (2C-B) compound in urine sample after solid phase extraxtion and derivatization with N-methyl-bis-trifluoroacetamide (MBTFA). Gas chromatographic separation of TFA derivative of 2C-B (2C-B TFA) was successfully performed using DB-5MS capillary column (5% diphenyl-95% dimethilsiloxane). Selected ion monitoring (SIM) technique was used for quantitative analyses which was performed using matrix matched calibratores, whereby good results were achieved. Urine sample which contained 2C-B was obtained within International Quality Assurance Programme-International Collaborative Exercises (ICE) program organized by the scientific department of United Nations Office on Drugs and Crime (UNODC). The aim of this study was to develop a simple and sensitive method of gas chromatography mass spectrometry (GC-EI-MS) for the identification, extraction and quantitative analysis of 2C-B in the urine sample, which is near the blood remains a priority analyzed matrix in clinical and forensic toxicology.
    Type of Medium: Online Resource
    ISSN: 2738-0971 , 2738-1013
    URL: Article
    DOI: 10.5937/bnsr12-28145
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2022
    detail.hit.zdb_id: 3054436-1
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  • 9
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    Učestalost i simptomatologija izmijenjene vaginalne flore kod žena na području opštine Foča
    Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča ; 2017
    In:  Биомедицинска истраживања Vol. 8, No. 1 ( 2017-07-19), p. 51-56
    Details
    In: Биомедицинска истраживања, Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča, Vol. 8, No. 1 ( 2017-07-19), p. 51-56
    Abstract: & lt;p & gt;Uvod. Bakterijska vaginoza predstavlja poremećaj u sastavu vaginalne floreu smislu smanjenja broja laktobacila, a predominacije anaerobnih bakterijaGardnerella vaginalis, Atopobium vaginae i Mobiluncus spp. Najče & amp;scaron;ći simptomudružen sa bakterijskom vaginozom je rijedak, homogen, mliječno bijeli ilisivkast vaginalni sekret, neprijatnog mirisa. Cilj rada je određivanje učestalostii simptomatologije izmijenjene vaginalne flore kod žena u reproduktivnomperiodu iz područja op & amp;scaron;tine Foča, Republika Srpska.Metode. Ispitivanje je obuhvatilo 100 žena u reproduktivnom periodu, pričemu trudnice nisu uključene u ovu studiju. Na direktnom preparatu obojenompo Gram-u, koristeći sistem bodovanja po Nugent-u, dijagnostikovana jeizmijenjena vaginalna flora. Na osnovu anamnestičkih podataka utvrđivalismo da li se pojedini simptomi če & amp;scaron;će javljaju u grupi ispitanica sa izmijenjenomvaginalnom florom (bakterijska vaginoza i intermedijerna flora) u odnosu nažene sa normalnom vaginalnom florom.Rezultati. Koristeći sistem bodovanja po Nugent-u bakterijska vaginoza jedijagnostikovana kod 22% ispitanica, intermedijerna flora je nađena kod 18%ispitanica, dok je njih 60% imalo normalnu vaginalnu floru. Kod ispitanicasa dijagnostikovanom bakterijskom vaginozom najče & amp;scaron;ći simptom je biopojačan sekret. Obradom podataka utvrđeno je da nema statistički značajnerazlike u učestalosti ispitivanih simptoma (pojačan sekret, peckanje, svrab)kod ispitanica sa izmijenjenom vaginalnom florom u odnosu na ispitanicesa normalnom vaginalnom florom. Asimptomatska bakterijska vaginoza jedijagnostikovana kod 4 (18,2%) ispitanice.Zaključak. Izmijenjena vaginalna flora, u vidu bakterijske vaginoze ili intermedijerneflore dijagnostikovana je kod 40% ispitanica. Među ispitanicama sadijagnostikovanom bakterijskom vaginozom najče & amp;scaron;ći simptom je bio pojačansekret ali nisu uočene značajne razlike u učestalosti simptomatoma kodžena sa izmijenjenom vaginalnom florom u odnosu na žene sa normalnomvaginalnom florom. & lt;/p & gt;
    Type of Medium: Online Resource
    ISSN: 1986-8537 , 1986-8529
    URL: Article
    DOI: 10.7251/bii1701051s
    Language: English
    Publisher: Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča
    Publication Date: 2017
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  • 10
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    Influence of nanosilica on the morphology, thermal and mechanical properties of polyurethane elastomer
    Wiley ; 2012
    In:  Journal of Applied Polymer Science Vol. 125, No. S1 ( 2012-07-25)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 125, No. S1 ( 2012-07-25)
    Abstract: In this article, the influence of fumed silica nanofiller on the structure and properties of segmented polyurethane elastomer (PUR) was investigated. In order to investigate the interactions at the filler–matrix interface, nonmodified and commercially modified fillers (with methacrylsilane and octylsilane) were used. The PUR composites with 1.0, 2.0, 4.0, 6.0, and 9.0 vol % of all fillers were prepared by solution casting method. Surface free energy of the fillers and polymer matrix was determined using contact angle measurements with different testing liquids. Change in morphology was analyzed using optical polarization microscopy and distribution of the filler in polymer matrix using scanning electron microscopy. The influences of silica fillers on mechanical and thermal properties of PUR were investigated. Results showed that surface treatment of silica filler with methacrylsilane and octylsilane reduces the agglomeration of particles that improves dispersion at microlevel. Addition of all fillers disrupts spherulite morphology and decreases crystallinity of the PUR matrix. Nonmodified silica nanofiller has the least pronounced influence on spherulite morphology and the lowest influence on polyurethane crystallinity and thus the best mechanical properties. Surface modification of silica with octylsilane has less influence on polyurethane crystallinity and on decreasing of mechanical properties than modification with methacrylsilane. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v125.1s
    DOI: 10.1002/app.36290
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1491105-X
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