In:
Molecular Systems Biology, EMBO, Vol. 10, No. 11 ( 2014-11)
Abstract:
image Metagenomic profiling of fecal samples from colorectal cancer ( CRC ) patients in comparison with tumor‐free controls reveals strong associations between the gut microbiota and cancer. Their potential for noninvasive cancer screening is explored systematically. A classification model based on gut microbial marker species distinguishes CRC patients from controls with similar accuracy as the fecal occult blood test ( FOBT ), routinely used for clinical screening. Combining metagenomic data with the FOBT leads to a relative improvement in sensitivity of 〉 45% over the FOBT alone at identical specificity. Detection accuracy of the metagenomic test is maintained in an independent study population and is still high for alternative microbiome readouts, such as the abundance of 16S rRNA OTUs or families of functionally related genes. Functional metagenomic analysis indicates an increased potential of CRC ‐associated microbiota for degradation of host glycans and amino acids and for pro‐inflammatory lipopolysaccharide metabolism.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
DOI:
10.15252/msb.20145645
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
2193510-5
SSG:
12
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