In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2022-6-14), p. e0269777-
Abstract:
Whether there are sex differences in hemodynamic profiles among people with elevated blood pressure is not well understood and could guide personalization of treatment. Methods and results We described the clinical and hemodynamic characteristics of adults with elevated blood pressure in China using impedance cardiography. We included 45,082 individuals with elevated blood pressure (defined as systolic blood pressure of ≥130 mmHg or a diastolic blood pressure of ≥80 mmHg), of which 35.2% were women. Overall, women had a higher mean systolic blood pressure than men (139.0 [±15.7] mmHg vs 136.8 [±13.8] mmHg, P 〈 0.001), but a lower mean diastolic blood pressure (82.6 [±9.0] mmHg vs 85.6 [±8.9] mmHg, P 〈 0.001). After adjusting for age, region, and body mass index, women 〈 50 years old had lower systemic vascular resistance index (beta-coefficient [β] -31.7; 95% CI: -51.2, -12.2) and higher cardiac index (β 0.07; 95% CI: 0.04, 0.09) than men of their same age group, whereas among those ≥50 years old women had higher systemic vascular resistance index (β 120.4; 95% CI: 102.4, 138.5) but lower cardiac index (β -0.15; 95% CI: -0.16, -0.13). Results were consistent with a propensity score matching sensitivity analysis, although the magnitude of the SVRI difference was lower and non-significant. However, there was substantial overlap between women and men in the distribution plots of these variables, with overlapping areas ranging from 78% to 88%. Conclusions Our findings indicate that there are sex differences in hypertension phenotype, but that sex alone is insufficient to infer an individual’s profile.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0269777
DOI:
10.1371/journal.pone.0269777.g001
DOI:
10.1371/journal.pone.0269777.g002
DOI:
10.1371/journal.pone.0269777.g003
DOI:
10.1371/journal.pone.0269777.g004
DOI:
10.1371/journal.pone.0269777.t001
DOI:
10.1371/journal.pone.0269777.t002
DOI:
10.1371/journal.pone.0269777.s001
DOI:
10.1371/journal.pone.0269777.s002
DOI:
10.1371/journal.pone.0269777.s003
DOI:
10.1371/journal.pone.0269777.s004
DOI:
10.1371/journal.pone.0269777.s005
DOI:
10.1371/journal.pone.0269777.s006
DOI:
10.1371/journal.pone.0269777.s007
DOI:
10.1371/journal.pone.0269777.s008
DOI:
10.1371/journal.pone.0269777.r001
DOI:
10.1371/journal.pone.0269777.r002
DOI:
10.1371/journal.pone.0269777.r003
DOI:
10.1371/journal.pone.0269777.r004
DOI:
10.1371/journal.pone.0269777.r005
DOI:
10.1371/journal.pone.0269777.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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