GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Influence of traditional ecological knowledge on conservation of the skywalker hoolock gibbon (Hoolock tianxing) outside nature reserves
    Elsevier BV ; 2020
    In:  Biological Conservation Vol. 241 ( 2020-01), p. 108267-
    Details
    In: Biological Conservation, Elsevier BV, Vol. 241 ( 2020-01), p. 108267-
    Type of Medium: Online Resource
    ISSN: 0006-3207
    URL: Article
    DOI: 10.1016/j.biocon.2019.108267
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1496231-7
    SSG: 12
    SSG: 23
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Colistin sulfate for decontamination of preservation fluid in kidney transplantation to decrease the incidence of donor‐derived infections caused by multidrug‐resistant Gram‐negative bacteria
    Wiley ; 2022
    In:  Transplant Infectious Disease Vol. 24, No. 3 ( 2022-06)
    Details
    In: Transplant Infectious Disease, Wiley, Vol. 24, No. 3 ( 2022-06)
    Abstract: Preservation fluid (PF) contamination, especially by multidrug‐resistant (MDR) Gram‐negative bacteria (GNB), poses a high risk of donor‐derived infection (DDI) and severe clinical outcomes. We sought to determine whether the use of colistin sulfate to decontaminate PF in kidney transplantation can decrease the incidence of probable DDI (p‐DDI) caused by MDR GNB. Methods In a retrospective study of 916 recipients who received deceased donation, 864 PF samples were collected and cultured, and microbiological contaminants were recorded with the recipients’ clinical data and outcomes. From March 2016 to May 2019, 624 samples were decontaminated with ceftizoxime, and from June 2019 to March 2021, 240 samples were decontaminated with colistin sulfate. Between‐group comparisons were performed to assess the ability of the two decontamination regimens to decrease the incidence of p‐DDI, especially MDR GNB‐related infection. Results The overall PF contamination rate was 54.51% (471/864), and 80 samples were positive for MDR GNB contamination. All p‐DDIs occurred in the ceftizoxime group ( p   〈  0.001), and 67.65% of p‐DDIs were MDR GNB‐related. In the ceftizoxime group, 23 of 61 cases of MDR GNB contamination led to related p‐DDIs, while none occurred in the colistin sulfate group ( p  = 0.002). Among the 23 patients with p‐DDIs, 5 died due to severe infection, and 2 experienced graft loss. Conclusions The goal of decontamination should be to decrease the risk of MDR GNB‐related p‐DDI, and colistin sulfate could be an effective and feasible option. image
    Type of Medium: Online Resource
    ISSN: 1398-2273 , 1399-3062
    URL: Issue
    URL: Article
    DOI: 10.1111/tid.v24.3
    DOI: 10.1111/tid.13820
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2010983-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia‐reperfusion injury
    Wiley ; 2021
    In:  Journal of Cellular and Molecular Medicine Vol. 25, No. 13 ( 2021-07), p. 6203-6216
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 25, No. 13 ( 2021-07), p. 6203-6216
    Abstract: Renal ischaemia‐reperfusion (IR) is a major cause of acute kidney injury (AKI). Cold‐inducible RNA‐binding protein (CIRBP) may contribute to AKI because its deficiency protects against renal IR injury in a mechanism believed to involve ferroptosis. We aimed to investigate whether ferroptosis is associated with CIRBP‐mediated renal damage. The differential expression of CIRBP was examined in tubular epithelial (HK2) cells during hypoxia‐reoxygenation (HR) or in response to erastin, an inducer of ferroptosis. CIRBP expression was increased in response to HR or erastin in HK2 cells but the silencing of CIRBP inhibited HR and erastin‐induced ferroptosis together with ferritinophagy. We discovered an interaction between CIRBP and ELAVL1 using STRING software, which was verified through co‐immunoprecipitation and fluorescence colocalization assays. We found that ELAVL1 is a critical regulator in the activation of ferritinophagy and the promotion of ferroptosis. HR or erastin also induced the expression of ELAVL1. An autophagy inhibitor (hydroxychloroquine) or si‐ELAVL1 transfection reversed CIRBP‐enhanced ferritinophagy activation and ferroptosis in HK2 cells under HR. Injection of anti‐CIRBP antibody into a mouse model of IR inhibited ferroptosis and decreased renal IR injury in vivo. In summary, our results provide evidence that ferritinophagy‐mediated ferroptosis could be responsible for CIRBP‐enhanced renal IR injury.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v25.13
    DOI: 10.1111/jcmm.16567
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2076114-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    SIRT3 protects kidneys from ischemia-reperfusion injury by modulating the DRP1 pathway to induce mitochondrial autophagy
    Elsevier BV ; 2021
    In:  Life Sciences Vol. 286 ( 2021-12), p. 120005-
    Details
    In: Life Sciences, Elsevier BV, Vol. 286 ( 2021-12), p. 120005-
    Type of Medium: Online Resource
    ISSN: 0024-3205
    URL: Article
    DOI: 10.1016/j.lfs.2021.120005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2013911-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Carbon-carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine
    Bentham Science Publishers Ltd. ; 2021
    In:  Drug Metabolism Letters Vol. 14, No. 1 ( 2021-05-05), p. 41-53
    Details
    In: Drug Metabolism Letters, Bentham Science Publishers Ltd., Vol. 14, No. 1 ( 2021-05-05), p. 41-53
    Abstract: Carbon-carbon bond cleavage of a saturated aliphatic moiety is rarely seen in xenobiotic metabolism. Olanexidine (Olanedine®), containing an n-octyl (C 8 ) side chain, was mainly metabolized to various shortened side chain (C 4 to C 6 ) acid-containing metabolites in vivo in preclinical species. In liver microsomes and S9, the major metabolites of olanexidine were from multi-oxidation on its n-octyl (C 8 ) side chain. However, the carbon-carbon bond cleavage mechanism of n-octyl (C 8 ) side chain, and enzyme(s) responsible for its metabolism in human remained unknown. Methods: A pair of regioisomers of α-ketol-containing C 8 side chain olanexidine analogs (3,2-ketol olanexidine and 2,3-ketol olanexidine) were synthesized, followed by incubation in human liver microsomes, recombinant human cytochrome P450 enzymes or human hepatocytes, and subsequent metabolite identification using LC/UV/MS. Results: Multiple shortened side chain (C 4 to C 6 ) metabolites were identified, including C 4 , C 5 and C 6 - acid and C 6 -hydroxyl metabolites. Among 19 cytochrome P450 enzymes tested, CYP2D6, CYP3A4 and CYP3A5 were identified to catalyze carbon-carbon bond cleavage. Conclusions: 3,2-ketol olanexidine and 2,3-ketol olanexidine were confirmed as the key intermediates in carbon-carbon bond cleavage. Its mechanism is proposed that a nucleophilic addition of iron-peroxo species, generated by CYP2D6 and CYP3A4/5, to the carbonyl group caused the carbon-carbon bond cleavage between the adjacent hydroxyl and ketone groups. As results, 2,3-ketol olanexidine formed a C 6 side chain acid metabolite. While, 3,2-ketol olanexidine formed a C 6 side chain aldehyde intermediate, which was either oxidized to a C 6 side chain acid metabolite or reduced to a C 6 side chain hydroxyl metabolite.
    Type of Medium: Online Resource
    ISSN: 1872-3128
    URL: Article
    DOI: 10.2174/1872312813666191125095818
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Hybrid simulation test and seismic assessment of CFDST moment resisting frame
    Elsevier BV ; 2023
    In:  Engineering Structures Vol. 292 ( 2023-10), p. 116353-
    Details
    In: Engineering Structures, Elsevier BV, Vol. 292 ( 2023-10), p. 116353-
    Type of Medium: Online Resource
    ISSN: 0141-0296
    URL: Article
    DOI: 10.1016/j.engstruct.2023.116353
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2002833-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy
    Frontiers Media SA ; 2018
    In:  Frontiers in Physiology Vol. 9 ( 2018-11-14)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 9 ( 2018-11-14)
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    DOI: 10.3389/fphys.2018.01526
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2018
    detail.hit.zdb_id: 2564217-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice
    Springer Science and Business Media LLC ; 2023
    In:  Stem Cell Research & Therapy Vol. 14, No. 1 ( 2023-07-03)
    Details
    In: Stem Cell Research & Therapy, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2023-07-03)
    Abstract: Islet transplantation is used therapeutically in a minority of patients with type 1 diabetes (T1D). However, successful outcomes are hampered by early islet β-cell loss caused by immune rejection and autoimmunity. Recent studies have demonstrated that mesenchymal stromal cells can enhance islet function both in vitro and in vivo by secreting ligands that activate islet G-protein coupled receptors (GPCRs). Stromal cell-derived factor 1 (SDF-1) is an MSC-secreted GPCR ligand, whereas the suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of STAT3-activating cytokines. Here, we determined whether improvement in islet function mediated by exogenous SDF-1 is impaired by SOCS3 in experimental models of T1D. Methods Isolated islets were cultured for 48 h with SDF-1. Cytokine-induced apoptosis was measured immediately. Islets from Socs3 −/− mice were pre-cultured with exogenous SDF-1 and transplanted underneath the kidney capsule of C57BL/6 mice with streptozotocin-induced diabetes. Blood glucose levels were monitored for 28 days. AMD3100, an antagonist of the SDF-1 ligand CXCR4, was administered subcutaneously to islet transplanted mice to inhibit CXCR4 before and after transplantation. Results SDF-1 protected islet cells from cytokine-induced apoptosis in vitro. SOCS3-knockout (KO) islets pretreated with SDF-1 were effective in reducing blood glucose in non-obese diabetic mice in vivo. We found that SDF-1 elicits localized immunosuppression in transplanted SOCS3-KO islets. Immunomodulation was observed when SOCS-KO islets were preconditioned with SDF-1. Gene expression and flow cytometric analyses revealed significantly decreased immune cell infiltration, inflammatory cytokines, and concomitant increases in FOXP3 + regulatory T cells, alternatively activated M2 macrophages, and dendritic cell phenotypes. Administration of AMD3100 impaired the SDF-1-mediated improvement in SOCS3-KO islet function and local immune suppression. Conclusion SDF-1 improves the function of islet grafts in autoimmune diabetes through regulation by CXCR4; however, the presence of SOCS3 reverses the protective effect of SDF-1 on islet grafts. These data reveal a molecular pathway that can elicit localized immunosuppression and delay graft destruction in transplanted islets.
    Type of Medium: Online Resource
    ISSN: 1757-6512
    URL: Article
    DOI: 10.1186/s13287-023-03347-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2548671-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    A high‐throughput glutathione trapping assay with combined high sensitivity and specificity in high‐resolution mass spectrometry by applying product ion extraction and data‐dependent neutral loss
    Wiley ; 2019
    In:  Journal of Mass Spectrometry Vol. 54, No. 2 ( 2019-02), p. 158-166
    Details
    In: Journal of Mass Spectrometry, Wiley, Vol. 54, No. 2 ( 2019-02), p. 158-166
    Abstract: Reactive metabolites are thought to play a pivotal role in the pathogenesis of some drug‐induced liver injury (DILI) and idiosyncratic adverse drug reactions (IADRs), which is of concern to patient safety and has been a cause of drugs being withdrawn from the market place. To identify drugs with a lower propensity for causing DILI and/or IADRs, high‐throughput assays to capture reactive metabolites are required in pharmaceutical industry for early drug discovery risk assessment. We describe the development of an assay to detect glutathione adducts with combined high sensitivity, enhanced specificity, and rapid data analysis. In this assay, compounds were incubated with human liver microsomes and a mixture of 1:1 of GSH (γ‐GluCysGly): GSX(γ‐GluCysGly‐ 13 C 2 15 N) in a 96‐well plate format. UPLC‐UV and LTQ Orbitrap XL were employed to detect GSH‐adducts using the following mass spectrometry setups: (a) selected ion monitoring (SIM) at m/z of 274 ± 3 Da in negative mode with in‐source fragmentation (SCID), which enables simultaneously monitoring two characteristic product ions of m/z 272.0888 (γ‐glutamyl‐dehydroalanyl‐glycine) and 275.0926 (γ‐glutamyl‐dehydroalanyl‐glycine‐ 13 C 2 15 N); (b) full scan mode for acquisition of exact mass of glutathione adducts; (c) data‐dependent MS 2 scan through isotopic matching (M:M + 3.00375 = 1:1) for monitoring neutral loss fragments (144 Da from dehydroalanyl‐glycine) and for structural information of glutathione adducts. This approach was qualified using eight compounds known to form GSH conjugates as reported in the literature. The high sensitivity and specificity were demonstrated in identifying unique CysGly adducts in the case of clozapine, diclofenac, and raloxifene and in identifying GSH‐adducts of fragmented parent molecules in the case of amodiaquine and troglitazone. In addition, LC‐UV chromatograms in the presence or absence of GSH/GSX allowed for identification of the rearranged glutathione adducts without aforementioned characteristic fragment ions. Implement of this assay in drug discovery small molecule programs has successfully guided drug design.
    Type of Medium: Online Resource
    ISSN: 1076-5174 , 1096-9888
    URL: Issue
    URL: Article
    DOI: 10.1002/jms.v54.2
    DOI: 10.1002/jms.4320
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2197367-2
    detail.hit.zdb_id: 1472468-6
    detail.hit.zdb_id: 7414-7
    SSG: 11
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Wild gibbons plan their travel pattern according to food types of breakfast
    The Royal Society ; 2023
    In:  Proceedings of the Royal Society B: Biological Sciences Vol. 290, No. 1999 ( 2023-05-31)
    Details
    In: Proceedings of the Royal Society B: Biological Sciences, The Royal Society, Vol. 290, No. 1999 ( 2023-05-31)
    Abstract: Planning for the future is a complex skill that is often considered uniquely human. This cognitive ability has never been investigated in wild gibbons (Hylobatidae). Here we evaluated the movement patterns from sleeping trees to out-of-sight breakfast trees in two groups of endangered skywalker gibbons ( Hoolock tianxing ). These Asian apes inhabit a cold seasonal montane forest in southwestern China. After controlling for possible confounding variables including group size, sleeping pattern (sleep alone or huddle together), rainfall and temperature, we found that food type (fruits or leaves) of the breakfast tree was the most important factor affecting gibbon movement patterns. Fruit breakfast trees were more distant from sleeping trees compared with leaf trees. Gibbons left sleeping trees and arrived at breakfast trees earlier when they fed on fruits compared with leaves. They travelled fast when breakfast trees were located further away from the sleeping trees. Our study suggests that gibbons had foraging goals in mind and plan their departure times accordingly. This ability may reflect a capacity for route-planning, which would enable them to effectively exploit highly dispersed fruit resources in high-altitude montane forests.
    Type of Medium: Online Resource
    ISSN: 0962-8452 , 1471-2954
    URL: Article
    DOI: 10.1098/rspb.2023.0430
    Language: English
    Publisher: The Royal Society
    Publication Date: 2023
    detail.hit.zdb_id: 1460975-7
    SSG: 12
    SSG: 25
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...