In:
International Journal of Experimental Pathology, Wiley, Vol. 99, No. 5 ( 2018-10), p. 210-217
Abstract:
The present study investigated the therapeutic potential of omega‐6 fatty acids, according to their effects on antioxidant markers and matrix metalloproteinases ( MMP s), in coronary heart disease‐induced rats. Rats were grouped into group I (sham control), group II (control), group III (0.5 g/kg bwt of omega‐6 fatty acids) and group IV (1 g/kg bwt of omega‐6 fatty acids). Reactive oxygen species ( ROS ), malondialdehyde ( MDA ), superoxide dismutase ( SOD ), reduced glutathione ( GSH ), catalase, glutathione peroxidase (Gpx) and acetylcholinesterase ( AC hE) enzyme activities were determined. ROS and MDA were substantially reduced, whereas SOD , catalase, Gpx and AC hE were significantly increased, following supplementation with omega‐6 fatty acids. MMP ‐2 mRNA expression was drastically increased by 95% in group II . Treatment significantly reduced MMP ‐2 mRNA expression by 12.3% and 26.7% in groups III and IV respectively. MMP ‐9 mRNA expression drastically increased, by 121%, in group II . Treatment significantly reduced MMP ‐9 mRNA expression by 22.6% and 29.4% in groups III and IV respectively. MMP ‐2 protein expression was drastically increased, by 81%, in group II . Treatment significantly reduced MMP ‐2 protein expression by 9.4% and 26% in groups III and IV respectively. MMP ‐9 protein expression was drastically increased, by 100%, in group II . Treatment significantly reduced MMP ‐9 protein expression by 18.9% and 26.9% in groups III and IV respectively. In summary, the consumption of omega‐6 fatty acids significantly decreased MDA and ROS , while SOD , catalase, GHS , Gpx and AC hE were increased. Furthermore, omega‐6 fatty acids significantly downregulated MMP ‐2 and MMP ‐9 expression in our coronary heart disease‐induced rat model.
Type of Medium:
Online Resource
ISSN:
0959-9673
,
1365-2613
DOI:
10.1111/iep.2018.99.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2010007-3
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